BMS-708163 is a γ-secretase inhibitor (GSI) (IC50 =0.3 nM).Potent, selective γ-secretase inhibitor of Aβ40 and Aβ42 with IC 50 of 0.3 nM and 0.27 nM, respectively, compared to IC 50 values of 41, 10, 33, and 38 nM respectively for signaling inhibiti
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Action Type
INHIBITOR
Mechanism of action
Gamma-secretase inhibitor
Note
Refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
1.Coric V, van Dyck CH, Salloway S, Andreasen N, Brody M, Richter RW, Soininen H, Thein S, Shiovitz T, Pilcher G et al.. (2012) Safety and tolerability of the γ-secretase inhibitor avagacestat in a phase 2 study of mild to moderate Alzheimer disease.. Arch Neurol, 69 (11):(1430-40). [PMID:22892585][10.1021/op500134e]
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