Avelumab (anti-PD-L1), for ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) various applications, specific to B7-H1 / PD-L1 / CD274, >95%, high purity, Human IgG1, OTHER of Programmed cell death 1 ligand 1 other
Avelumab (anti-PD-L1), for ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) various applications, specific to B7-H1 / PD-L1 / CD274, >95%, high purity, Human IgG1, OTHER of Programmed cell death 1 ligand 1 other
Avelumab (anti-PD-L1), for ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) various applications, specific to B7-H1 / PD-L1 / CD274, >95%, high purity, Human IgG1
Specifications & Purity
Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, ≥95%(SDS-PAGE&SEC), See COA
Avelumab is a fully human IgG1 monoclonal antibody that targets the protein programmed death-ligand 1 (PD-L1). Avelumab exhibits potential antibody-dependent cell-mediated cytotoxicity and is used for the treatment of several kinds of carcinoma. Purity >95% (SDS-PAGE&SEC) Endotoxin Level < 1.0EU/mg
Product Properties
Antibody Type
Primary antibody
Clonality
Recombinant
Isotype
Human IgG1
Light Chain Type
lambda
SDS-PAGE
28.7 kDa (Light Chain) & 50.1 kDa (Heavy Chain), under reducing conditions; 182.4 kDa, under non-reducing conditions.
Purification Method
Protein A purified
Purity
>95%
Source
CHO supernatant
Form
Liquid
Concentration
See COA
Storage Temp
Store at -80°C,Avoid repeated freezing and thawing
Shipped In
Ice chest + Ice pads
Stability And Storage
Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle.
CAS
1537032-82-8
Images
Avelumab (anti-PD-L1) (A412006) - Flow Cytometry Flow Cytometry analysis of PHA-stimulated (3 days) human peripheral blood lymphocytes labelling PD-L1 with Avelumab (anti-PD-L1) (A412006) conjugated with biotin (right panel) compared with Human IgG (Ab170213) conjugated with biotin - Isotype Control (left panel) and detected with SA-PE (rp156250).
Avelumab (anti-PD-L1) (A412006) - Flow Cytometry Flow Cytometry analysis of PHA-stimulated (3 days) human peripheral blood lymphocytes labelling PD-L1 (red) with Avelumab (anti-PD-L1) (A412006) conjugated with biotin and detected with SA-PE (rp156250). Blue - Isotype control, human IgG (Ab170213) conjugated with biotin. Black - Unlabelled control, cells without incubation with primary antibody.
Avelumab (anti-PD-L1) (A412006) - SEC The purity of Avelumab (anti-PD-L1) (A412006) is more than 95% verified by HPLC.
Associated Targets(Human)
CD274TclinProgrammed cell death 1 ligand 1 (0 Activities)
1.Pardoll DM. (2012) The blockade of immune checkpoints in cancer immunotherapy.. Nat Rev Cancer, 12 (4):(252-64). [PMID:22437870][10.1021/op500134e]
2.Topalian SL, Drake CG, Pardoll DM. (2015) Immune checkpoint blockade: a common denominator approach to cancer therapy.. Cancer Cell, 27 (4):(450-61). [PMID:25858804][10.1021/op500134e]
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