Avermectin B1a - 95%, high purity , CAS No.65195-55-3

9 Citations
  • ≥95%
Item Number
A329452
Grouped product items
SKUSizeAvailabilityPrice Qty
A329452-1mg
1mg
In stock
$152.90
A329452-5mg
5mg
In stock
$684.90
A329452-25mg
25mg
In stock
$3,078.90
A329452-100mg
100mg
In stock
$11,080.90
A329452-500mg
500mg
In stock
$49,863.90

a macrocyclic lactone with insecticide and acaricide properties

Basic Description

SynonymsAVERMECTIN B1A | 65195-55-3 | Abamectin B1a | abamectin component B1a | 5-O-Demethylavermectin A1a | Avermectin B(1)a | Avermectin A1a, 5-O-demethyl- | Antibiotic C 076B1a | Caswell No. 063AB | Abamectin komponente B1a | Abamectinum [Latin] | EINECS 265-610-3 | UNII-K54ZMM929K | A
Specifications & Purity≥95%
Storage TempStore at -20°C,Argon charged
Shipped InIce chest + Ice pads
Product Description

Avermectin B1a is a macrocyclic lactone that makes up a large component of the anthelimintic Abamectin used to control parasitic nematodes in livestock. Avermectin B1a also acts as an insecticide and acaricide. The avermectins are used commercially as antiparasitic agents in animal health, agriculture and human infections. Research shows that it can activate and inhibit GABA|A|Rα1 (gamma-aminobutyric acidA) receptor function in mammalian brain.

Associated Targets(Human)

HSPD1 Tbio HSP60/HSP10 (366 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TST Tchem Thiosulfate sulfurtransferase (144 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Artemia salina (1320 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Oesophagostomum columbianum (45 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium berghei (192651 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Calliphoridae (33 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Ovis aries (854 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Caenorhabditis elegans (1055 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Haemonchus contortus (724 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Trichostrongylus colubriformis (210 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Trichoplusia ni (986 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cooperia oncophora (36 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Spodoptera eridania (79 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Tetranychus urticae (2600 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Stomoxys calcitrans (84 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Trichostrongylus axei (45 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Teladorsagia circumcincta (67 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
B16 (5829 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
groL GroEL/GroES (1042 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
groEL 60 kDa chaperonin (64 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

Pubchem Sid488195776
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488195776
IUPAC Name (1'R,2R,3S,4'S,6S,8'R,10'E,12'S,13'S,14'E,16'E,20'R,21'R,24'S)-2-[(2S)-butan-2-yl]-21',24'-dihydroxy-12'-[(2R,4S,5S,6S)-5-[(2S,4S,5S,6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy-4-methoxy-6-methyloxan-2-yl]oxy-3,11',13',22'-tetramethylspiro[2,3-dihydropyran-6,6'-3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene]-2'-one
INCHI InChI=1S/C48H72O14/c1-11-25(2)43-28(5)17-18-47(62-43)23-34-20-33(61-47)16-15-27(4)42(26(3)13-12-14-32-24-55-45-40(49)29(6)19-35(46(51)58-34)48(32,45)52)59-39-22-37(54-10)44(31(8)57-39)60-38-21-36(53-9)41(50)30(7)56-38/h12-15,17-19,25-26,28,30-31,33-45,49-50,52H,11,16,20-24H2,1-10H3/b13-12+,27-15+,32-14+/t25-,26-,28-,30-,31-,33+,34-,35-,36-,37-,38-,39-,40+,41-,42-,43+,44-,45+,47+,48+/m0/s1
InChi Key RRZXIRBKKLTSOM-XPNPUAGNSA-N
Canonical SMILES CCC(C)C1C(C=CC2(O1)CC3CC(O2)CC=C(C(C(C=CC=C4COC5C4(C(C=C(C5O)C)C(=O)O3)O)C)OC6CC(C(C(O6)C)OC7CC(C(C(O7)C)O)OC)OC)C)C
Isomeric SMILES CC[C@H](C)[C@@H]1[C@H](C=C[C@@]2(O1)C[C@@H]3C[C@H](O2)C/C=C(/[C@H]([C@H](/C=C/C=C/4\CO[C@H]5[C@@]4([C@@H](C=C([C@H]5O)C)C(=O)O3)O)C)O[C@H]6C[C@@H]([C@H]([C@@H](O6)C)O[C@H]7C[C@@H]([C@H]([C@@H](O7)C)O)OC)OC)\C)C
PubChem CID 6434889
Molecular Weight 873.1

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

10 results found

Lot NumberCertificate TypeDateItem
C2318645Certificate of AnalysisFeb 11, 2023 A329452
C2318650Certificate of AnalysisFeb 11, 2023 A329452
C2318652Certificate of AnalysisFeb 11, 2023 A329452
C2318653Certificate of AnalysisFeb 11, 2023 A329452
C2318654Certificate of AnalysisFeb 11, 2023 A329452
C2318658Certificate of AnalysisFeb 11, 2023 A329452
C2318664Certificate of AnalysisFeb 11, 2023 A329452
C2318666Certificate of AnalysisFeb 11, 2023 A329452
C2318667Certificate of AnalysisFeb 11, 2023 A329452
C2318683Certificate of AnalysisFeb 11, 2023 A329452

Chemical and Physical Properties

SolubilitySoluble in ethanol, methanol, DMF or DMSO
SensitivityMoisture sensitive
Refractive Index1.571

Safety and Hazards(GHS)

Pictogram(s) GHS06,   GHS08,   GHS09
Signal Danger
Hazard Statements

H311:Toxic in contact with skin

H400:Very toxic to aquatic life

H410:Very toxic to aquatic life with long lasting effects

H300:Fatal if swallowed

H330:Fatal if inhaled

H372:Causes damage to organs through prolonged or repeated exposure

H361:Suspected of damaging fertility or the unborn child

Precautionary Statements

P273:Avoid release to the environment.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P260:Do not breathe dust/fume/gas/mist/vapors/spray.

P284:[In case of inadequate ventilation] Wear respiratory protection.

P271:Use only outdoors or in a well-ventilated area.

P270:Do not eat, drink or smoke when using this product.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P391:Collect spillage.

P330:Rinse mouth.

P320:Specific treatment is urgent (see ... on this label).

P361+P364:Take off immediately all contaminated clothing and wash it before reuse.

P203:Obtain, read and follow all safety instructions before use.

P301+P316:IF SWALLOWED: Get emergency medical help immediately.

P318:if exposed or concerned, get medical advice.

P316:Get emergency medical help immediately.

P319:Get medical help if you feel unwell.

Related Documents

Citations of This Product

1. Guanglu Wang, Yue Xin, Kaixin Ping, Xuhui Xu, Ying Sun, Xing Li, Xinying Guan, Jingquan Dong.  (2023)  Silybin mitigates chronic Avermectin exposure-induced intestinal damage and growth inhibition in carp.  ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,    (104351).  [PMID:38135203]
2. Song Lianjun, Wang Youyi, Li Qingyue, Wang Jinkui, Gao Tian, An Zhaohuan, Liu Qinfang, Mao Yexuan, Bu Tong, Huang Xianqing, Ma Yan, Wang Zhanhui, Zhang Xiya.  (2024)  Production of monoclonal antibody against tylosin and tilmicosin with homogeneous cross-reactivity and its application in lateral flow immunoassay.  MICROCHIMICA ACTA,  191  (1): (1-12).  [PMID:38114730]
3. Xu Xuhui, Zhou Mengyuan, Xie Kunmei, Zhang Shuai, Ji Xiaomeng, Sun Ying, Li Qiulu, Dong Zibo.  (2023)  Mitigation of avermectin exposure-induced brain tissue damage in carp by quercetin.  FISH PHYSIOLOGY AND BIOCHEMISTRY,    (1-15).  [PMID:37831371]
4. Guanglu Wang, Jiajia Guo, Yeyun Ma, Yue Xin, Xiaomeng Ji, Ying Sun, Jian Zhang, Jingquan Dong.  (2023)  Ferulic acid alleviates carp brain damage and growth inhibition caused by avermectin by modulating the Nrf2/Keap1 and NF-κB signaling pathways.  PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY,  196  (105590).  [PMID:37945241]
5. Pan En-Zhuang, Xin Yue, Li Xue-Qing, Wu Xin-Yu, Tan Xue-Lian, Dong Jing-Quan.  (2023)  Ameliorative effects of silybin against avermectin-triggered carp spleen mitochondrial dysfunction and apoptosis through inhibition of PERK-ATF4-CHOP signaling pathway.  FISH PHYSIOLOGY AND BIOCHEMISTRY,    (1-16).  [PMID:37542703]
6. Enzhuang Pan, Huizhen Chen, Xinyu Wu, Nana He, Jiajie Gan, Huimiao Feng, Yong Sun, Jingquan Dong.  (2023)  Protective effect of quercetin on avermectin induced splenic toxicity in carp: Resistance to inflammatory response and oxidative damage.  PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY,  193  (105445).  [PMID:37248014]
7. Yifan Li, Shujun Ni, Yunping Wang, Ruichi Li, Hong Sun, Xuan Ye, Zhen Tian, Yalin Zhang, Jiyuan Liu.  (2023)  The chemosensory protein 1 contributes to indoxacarb resistance in Plutella xylostella (L.).  PEST MANAGEMENT SCIENCE,      [PMID:36809665]
8. Tianmeng Zhang, Zhuhua Dong, Feixue Liu, Enzhuang Pan, Nana He, Fenfen Ma, Xinyu Wu, Yan Wang, Jingquan Dong.  (2022)  Non-target toxic effects of avermectin on carp spleen involve oxidative stress, inflammation, and apoptosis.  PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY,  187  (105190).  [PMID:36127050]
9. Zhiping Che, Xiaolong Guo, Yuanhao Li, Song Zhang, Lina Zhu, Jiaxuan He, Di Sun, Yihao Guo, Yibo Liu, Ruxue Wei, Xiaobo Huang, Shengming Liu, Genqiang Chen, Yuee Tian.  (2022)  Synthesis of paeonol ester derivatives and their insecticidal, nematicidal, and anti-oomycete activities.  PEST MANAGEMENT SCIENCE,  78  (8): (3442-3455).  [PMID:35567371]

References

1. Guanglu Wang, Yue Xin, Kaixin Ping, Xuhui Xu, Ying Sun, Xing Li, Xinying Guan, Jingquan Dong.  (2023)  Silybin mitigates chronic Avermectin exposure-induced intestinal damage and growth inhibition in carp.  ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,    (104351).  [PMID:38135203]
2. Song Lianjun, Wang Youyi, Li Qingyue, Wang Jinkui, Gao Tian, An Zhaohuan, Liu Qinfang, Mao Yexuan, Bu Tong, Huang Xianqing, Ma Yan, Wang Zhanhui, Zhang Xiya.  (2024)  Production of monoclonal antibody against tylosin and tilmicosin with homogeneous cross-reactivity and its application in lateral flow immunoassay.  MICROCHIMICA ACTA,  191  (1): (1-12).  [PMID:38114730]
3. Xu Xuhui, Zhou Mengyuan, Xie Kunmei, Zhang Shuai, Ji Xiaomeng, Sun Ying, Li Qiulu, Dong Zibo.  (2023)  Mitigation of avermectin exposure-induced brain tissue damage in carp by quercetin.  FISH PHYSIOLOGY AND BIOCHEMISTRY,    (1-15).  [PMID:37831371]
4. Guanglu Wang, Jiajia Guo, Yeyun Ma, Yue Xin, Xiaomeng Ji, Ying Sun, Jian Zhang, Jingquan Dong.  (2023)  Ferulic acid alleviates carp brain damage and growth inhibition caused by avermectin by modulating the Nrf2/Keap1 and NF-κB signaling pathways.  PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY,  196  (105590).  [PMID:37945241]
5. Pan En-Zhuang, Xin Yue, Li Xue-Qing, Wu Xin-Yu, Tan Xue-Lian, Dong Jing-Quan.  (2023)  Ameliorative effects of silybin against avermectin-triggered carp spleen mitochondrial dysfunction and apoptosis through inhibition of PERK-ATF4-CHOP signaling pathway.  FISH PHYSIOLOGY AND BIOCHEMISTRY,    (1-16).  [PMID:37542703]
6. Enzhuang Pan, Huizhen Chen, Xinyu Wu, Nana He, Jiajie Gan, Huimiao Feng, Yong Sun, Jingquan Dong.  (2023)  Protective effect of quercetin on avermectin induced splenic toxicity in carp: Resistance to inflammatory response and oxidative damage.  PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY,  193  (105445).  [PMID:37248014]
7. Yifan Li, Shujun Ni, Yunping Wang, Ruichi Li, Hong Sun, Xuan Ye, Zhen Tian, Yalin Zhang, Jiyuan Liu.  (2023)  The chemosensory protein 1 contributes to indoxacarb resistance in Plutella xylostella (L.).  PEST MANAGEMENT SCIENCE,      [PMID:36809665]
8. Tianmeng Zhang, Zhuhua Dong, Feixue Liu, Enzhuang Pan, Nana He, Fenfen Ma, Xinyu Wu, Yan Wang, Jingquan Dong.  (2022)  Non-target toxic effects of avermectin on carp spleen involve oxidative stress, inflammation, and apoptosis.  PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY,  187  (105190).  [PMID:36127050]
9. Zhiping Che, Xiaolong Guo, Yuanhao Li, Song Zhang, Lina Zhu, Jiaxuan He, Di Sun, Yihao Guo, Yibo Liu, Ruxue Wei, Xiaobo Huang, Shengming Liu, Genqiang Chen, Yuee Tian.  (2022)  Synthesis of paeonol ester derivatives and their insecticidal, nematicidal, and anti-oomycete activities.  PEST MANAGEMENT SCIENCE,  78  (8): (3442-3455).  [PMID:35567371]

Solution Calculators