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AX 15836 - ≥98%(HPLC), high purity , CAS No.2035509-96-5, Inhibitor of mitogen-activated protein kinase 7

  • Moligand™
  • ≥98%(HPLC)
Item Number
A287667
Grouped product items
SKUSizeAvailabilityPrice Qty
A287667-2mg
2mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$129.90
A287667-5mg
5mg
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Production requires sourcing of materials. We appreciate your patience and understanding.
$224.90
A287667-10mg
10mg
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Production requires sourcing of materials. We appreciate your patience and understanding.
$331.90
A287667-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$688.90
A287667-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,163.90
A287667-100mg
100mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,095.90
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Potent and selective ERK5 inhibitor

View related series
mitogen-activated protein kinase 7 Inhibitor

Basic Description

Specifications & PurityMoligand™, ≥98%(HPLC)
Biochemical and Physiological MechanismsPotent and selective ERK5 inhibitor (IC50= 8 nM). Exhibits >1,000-fold selectivity for ERK5 over a panel of over 200 kinases. Also exhibits selectivity over bromodomain BRD4 (Kd= 3,600 nM). Increases vomocytosis in human macrophagesin vitro, as well as i
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of mitogen-activated protein kinase 7

Associated Targets

BRD4 Tchem Bromodomain-containing protein 4 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

MAPK7 Tchem Mitogen-activated protein kinase 7 2 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 2-[2-ethoxy-4-[4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl]anilino]-5-methyl-11-methylsulfonylpyrimido[4,5-b][1,4]benzodiazepin-6-one
INCHI InChI=1S/C32H40N8O5S/c1-5-45-28-20-22(30(41)39-14-12-23(13-15-39)38-18-16-36(2)17-19-38)10-11-25(28)34-32-33-21-27-29(35-32)40(46(4,43)44)26-9-7-6-8-24(26)31(42)37(27)3/h6-11,20-21,23H,5,12-19H2,1-4H3,(H,33,34,35)
InChi Key HTFNVAVTYILUCF-UHFFFAOYSA-N
Canonical SMILES CCOC1=C(C=CC(=C1)C(=O)N2CCC(CC2)N3CCN(CC3)C)NC4=NC=C5C(=N4)N(C6=CC=CC=C6C(=O)N5C)S(=O)(=O)C
Isomeric SMILES CCOC1=C(C=CC(=C1)C(=O)N2CCC(CC2)N3CCN(CC3)C)NC4=NC=C5C(=N4)N(C6=CC=CC=C6C(=O)N5C)S(=O)(=O)C
PubChem CID 122705989
Molecular Weight 648.78

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

SolubilitySolvent:1eq. HCl, Max Conc. mg/mL: 64.88, Max Conc. mM: 100; Solvent:DMSO, Max Conc. mg/mL: 64.88, Max Conc. mM: 100

Related Documents

 SDS

 Specification Sheet

References

1. Lin EC, Amantea CM, Nomanbhoy TK, Weissig H, Ishiyama J, Hu Y, Sidique S, Li B, Kozarich JW, Rosenblum JS.  (2016)  ERK5 kinase activity is dispensable for cellular immune response and proliferation..  Proc Natl Acad Sci U S A,  113  (42): (11865-11870).  [PMID:27679845]
2. Cook SJ, Tucker JA, Lochhead PA.  (2020)  Small molecule ERK5 kinase inhibitors paradoxically activate ERK5 signalling: be careful what you wish for…..  Biochem Soc Trans,  48  (5): (1859-1875).  [PMID:32915196]

Solution Calculators

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