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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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A129732-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $17.90 | |
A129732-50mg | 50mg | In stock | $31.90 | |
A129732-250mg | 250mg | In stock | $99.90 | |
A129732-1g | 1g | In stock | $207.90 | |
A129732-5g | 5g | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $724.90 |
Potent VEGFR-1, -2 and -3 inhibitor
Synonyms | AG13736 | AG-13736 | Benzamide, N-methyl-2-((3-((1E)-2-(2-pyridinyl)ethenyl)-1H-indazo)-6-yl)thio)- | NCGC00241108-04 | N-methyl-2-({3-[(1E)-2-(pyridin-2-yl)ethenyl]-1H-indazol-6-yl}sulfanyl)benzamide | SR-01000941566 | SR-01000941566-1 | BRD-K29905972-00 |
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Specifications & Purity | Moligand™, ≥99% |
Biochemical and Physiological Mechanisms | Potent inhibitor of VEGFR-2, -3, and -1 (IC50values are 0.2, 0.1-0.3, and 1.2 nM respectively). Exhibits minimal activity against a panel of ~100 protein kinase. Inhibits angiogenesis and vascular permeability. Also a high affinity BCR-ABL1 (T315I) inhibi |
Legal Information | Sold for research purposes under agreement from Pfizer Inc. - Not for human or veterinary use. |
Storage Temp | Protected from light,Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Vascular endothelial growth factor receptor inhibitor |
Product Description |
Axitinib is a non-selective receptor kinase inhibitor of Flt and Flk proteins. This compound also inhibits Flt-1(VEGFR-1), Flk-1(VEGFR-2), Flt-4(VEGFR-3), PDGFR-β and c-Kit(c-KIT) with IC50 of 0.1 nM, 0.2 nM, 0.1-0.3 nM, 1.6 nM and 1.7 nM, respectively. Axitinib is studied as an antitumor agent of various cell lines. Axitinib is an inhibitor of PDGFR-β.An inhibitor of Flt and Flk (VEGFR) with antitumor properties
Application:
Axitinib has been used as a vascular endothelial growth factor (VEGF) receptor tyrosine kinase inhibitor (TKI) to study its effect on renal cancer cell proliferation in vitro. It has also been used to inhibit anterior mesenteric artery (AMA) angiogenesis in dechlorinated embryos maintained in conditioned water (CW). |
ALogP | 4.2 |
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Pubchem Sid | 488195799 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488195799 |
IUPAC Name | N-methyl-2-[[3-[(E)-2-pyridin-2-ylethenyl]-1H-indazol-6-yl]sulfanyl]benzamide |
INCHI | InChI=1S/C22H18N4OS/c1-23-22(27)18-7-2-3-8-21(18)28-16-10-11-17-19(25-26-20(17)14-16)12-9-15-6-4-5-13-24-15/h2-14H,1H3,(H,23,27)(H,25,26)/b12-9+ |
InChi Key | RITAVMQDGBJQJZ-FMIVXFBMSA-N |
Canonical SMILES | CNC(=O)C1=CC=CC=C1SC2=CC3=C(C=C2)C(=NN3)C=CC4=CC=CC=N4 |
Isomeric SMILES | CNC(=O)C1=CC=CC=C1SC2=CC3=C(C=C2)C(=NN3)/C=C/C4=CC=CC=N4 |
WGK Germany | 3 |
PubChem CID | 6450551 |
Molecular Weight | 386.47 |
CAS Registry No. | 319460-85-0 |
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Wikipedia | Axitinib |
DiscoveRx TREEspot | AG-013736| |
PubChem CID | 6450551 |
DrugBank Ligand | DB06626 |
ChEMBL Ligand | CHEMBL1289926 |
RCSB PDB Ligand | AXI |
PEP | axitinib |
Reactome Reaction | R-HSA-9669854, R-HSA-9669900, R-HSA-9674430, R-HSA-9674095 |
Reactome Drug | R-ALL-9669719 |
DrugCentral Ligand | 4225 |
PubChem SID | 488195799 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
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C2426019 | Certificate of Analysis | Mar 30, 2024 | A129732 |
C2419028 | Certificate of Analysis | Mar 09, 2024 | A129732 |
C2419029 | Certificate of Analysis | Mar 09, 2024 | A129732 |
I1410008 | Certificate of Analysis | Mar 08, 2024 | A129732 |
L2103396 | Certificate of Analysis | Sep 19, 2023 | A129732 |
L2103397 | Certificate of Analysis | Sep 19, 2023 | A129732 |
L2103398 | Certificate of Analysis | Sep 19, 2023 | A129732 |
C23031368 | Certificate of Analysis | Nov 15, 2021 | A129732 |
Solubility | Solvent:DMSO, Max Conc. mg/mL: 9.66, Max Conc. mM: 25 |
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Sensitivity | light & Moisture & heat & air sensitive |
Pictogram(s) | GHS08, GHS09, GHS07 |
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Signal | Warning |
Hazard Statements | H341:Suspected of causing genetic defects H373:Causes damage to organs through prolonged or repeated exposure H302:Harmful if swallowed H400:Very toxic to aquatic life H361:Suspected of damaging fertility or the unborn child |
Precautionary Statements | P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P281:Use personal protective equipment as required. P270:Do not eat, drink or smoke when using this product. P391:Collect spillage. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |
Starting at $47.90