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AZ 3146 - ≥98%, high purity , CAS No.1124329-14-1, Inhibitor of TTK protein kinase

Item Number
A127268
Grouped product items
SKUSizeAvailabilityPrice Qty
A127268-10mg
10mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$109.90
A127268-25mg
25mg
In stock
$247.90
A127268-50mg
50mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$325.90
A127268-100mg
100mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$587.90
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Potent and selective Mps1 kinase inhibitor

View related series
Cell Cycle/DNA Damage Cytoskeleton Mps1 TTK protein kinase Inhibitor

Basic Description

SynonymsAKOS024457919 | CS-0883 | SW219317-1 | HY-14710 | CCG-264989 | AZ3146 | AZ-3146 | 9-cyclopentyl-2-(2-methoxy-4-(1-methylpiperidin-4-yloxy)phenylamino)-7-methyl-7H-purin-8(9H)-one | NCGC00263090-01 | AZ 3146 | AU5 | J-002776 | J-519504 | PD136235 | AC-2740
Specifications & PurityMoligand™, ≥98%
Biochemical and Physiological MechanismsPotent and selective monopolar spindle 1 (Mps1) kinase inhibitor (IC50= 35 nM). Displays selectivity over 46 other kinases including Cdk1 and aurora kinase B. Interferes with chromosome alignment and overrides spindle assembly checkpoint. Inhibits the rec
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of TTK protein kinase
Note50mg、10mg、100mg卖完停产，不再备货
Product Description

AZ3146 is a potent and selective monopolar spindle 1 (Mps1) kinase inhibitor (IC50 = 35 nM); less potent to FAK, JNK1, JNK2, and Kit.
A potent and selective monopolar spindle 1 (Mps1) kinase inhibitor

Associated Targets(Human)

TTK Tchem Dual specificity protein kinase TTK (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
KIT Tclin Stem cell growth factor receptor (10667 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTK2 Tclin Focal adhesion kinase 1 (4730 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MAPK9 Tchem c-Jun N-terminal kinase 2 (4655 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MAPK8 Tchem c-Jun N-terminal kinase 1 (5038 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
YES1 Tclin Tyrosine-protein kinase YES (2781 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AURKA Tchem Serine/threonine-protein kinase Aurora-A (10240 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
STK17B Tchem Serine/threonine-protein kinase 17B (773 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TTK Tchem Dual specificity protein kinase TTK (2978 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HCT-116 (91556 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HepG2 (196354 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CDK2 Tchem CDK2/Cyclin A2 (2260 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name 9-cyclopentyl-2-[2-methoxy-4-(1-methylpiperidin-4-yl)oxyanilino]-7-methylpurin-8-one
INCHI InChI=1S/C24H32N6O3/c1-28-12-10-17(11-13-28)33-18-8-9-19(21(14-18)32-3)26-23-25-15-20-22(27-23)30(24(31)29(20)2)16-6-4-5-7-16/h8-9,14-17H,4-7,10-13H2,1-3H3,(H,25,26,27)
InChi Key YUKWVHPTFRQHMF-UHFFFAOYSA-N
Canonical SMILES CN1CCC(CC1)OC2=CC(=C(C=C2)NC3=NC=C4C(=N3)N(C(=O)N4C)C5CCCC5)OC
Isomeric SMILES CN1CCC(CC1)OC2=CC(=C(C=C2)NC3=NC=C4C(=N3)N(C(=O)N4C)C5CCCC5)OC
PubChem CID 56973724
Molecular Weight 452.55

Certificates

Certificate of Analysis(COA)

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3 results found

Lot NumberCertificate TypeDateItem
D1615042Certificate of AnalysisSep 12, 2023 A127268
A1822013Certificate of AnalysisJun 08, 2023 A127268
H2230042Certificate of AnalysisSep 03, 2022 A127268

Chemical and Physical Properties

SolubilitySolvent:DMSO, Max Conc. mg/mL: 11.31, Max Conc. mM: 25; Solvent:ethanol, Max Conc. mg/mL: 33.94, Max Conc. mM: 75
Refractive Index1.63
Boil Point(°C)621.04 °C at 760 mmHg

Related Documents

 SDS

 Specification Sheet

References

1. Hewitt L, Tighe A, Santaguida S, White AM, Jones CD, Musacchio A, Green S, Taylor SS.  (2010)  Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1-C-Mad2 core complex..  J Cell Biol,  190  (1): (25-34).  [PMID:20624899] [10.1021/op500134e]

Solution Calculators

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