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AZ 3146 - ≥98%, high purity , CAS No.1124329-14-1, Inhibitor of TTK protein kinase

Moligand™
≥98%

CAS#: 1124329-14-1
Formula: C₂₄H₃₂N₆O₃
Molecular Weight: 452.55
PubChem CID: 56973724

Item Number

A127268

Grouped product items
SKU	Size	Availability	Price
A127268-10mg	10mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$109.90
A127268-25mg	25mg	In stock	$247.90
A127268-50mg	50mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$325.90
A127268-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$587.90

Potent and selective Mps1 kinase inhibitor

View related series

TTK protein kinase Inhibitor

Basic Description

Synonyms	1124329-14-1\|AZ3146\|AZ 3146\|AZ-3146\|9-cyclopentyl-2-(2-methoxy-4-(1-methylpiperidin-4-yloxy)phenylamino)-7-methyl-7H-purin-8(9H)-one\|9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one\|CHEMBL214052
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	Potent and selective monopolar spindle 1 (Mps1) kinase inhibitor (IC50= 35 nM). Displays selectivity over 46 other kinases including Cdk1 and aurora kinase B. Interferes with chromosome alignment and overrides spindle assembly checkpoint. Inhibits the rec
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of TTK protein kinase
Note	50mg、10mg、100mg卖完停产，不再备货
Product Description	AZ3146 is a potent and selective monopolar spindle 1 (Mps1) kinase inhibitor (IC50 = 35 nM); less potent to FAK, JNK1, JNK2, and Kit. A potent and selective monopolar spindle 1 (Mps1) kinase inhibitor

Associated Targets

PTK2 Tclin Focal adhesion kinase 1 0 Activities

Discover Target: PTK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CDK2 Tchem Cyclin-dependent kinase 2 0 Activities

Discover Target: CDK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

STK17B Tchem Serine/threonine-protein kinase 17B 0 Activities

Discover Target: STK17B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

YES1 Tclin Tyrosine-protein kinase Yes 0 Activities

Discover Target: YES1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TTK Tchem Dual specificity protein kinase TTK 2 Activities

Discover Target: TTK

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAPK8 Tchem Mitogen-activated protein kinase 8 0 Activities

Discover Target: MAPK8

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AURKA Tchem Aurora kinase A 0 Activities

Discover Target: AURKA

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KIT Tclin Mast/stem cell growth factor receptor Kit 0 Activities

Discover Target: KIT

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAPK9 Tchem Mitogen-activated protein kinase 9 0 Activities

Discover Target: MAPK9

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	9-cyclopentyl-2-[2-methoxy-4-(1-methylpiperidin-4-yl)oxyanilino]-7-methylpurin-8-one
INCHI	InChI=1S/C24H32N6O3/c1-28-12-10-17(11-13-28)33-18-8-9-19(21(14-18)32-3)26-23-25-15-20-22(27-23)30(24(31)29(20)2)16-6-4-5-7-16/h8-9,14-17H,4-7,10-13H2,1-3H3,(H,25,26,27)
InChi Key	YUKWVHPTFRQHMF-UHFFFAOYSA-N
Canonical SMILES	CN1CCC(CC1)OC2=CC(=C(C=C2)NC3=NC=C4C(=N3)N(C(=O)N4C)C5CCCC5)OC
Isomeric SMILES	CN1CCC(CC1)OC2=CC(=C(C=C2)NC3=NC=C4C(=N3)N(C(=O)N4C)C5CCCC5)OC
PubChem CID	56973724
Molecular Weight	452.55

PubChem CID

ChEMBL Ligand

CAS Registry No.

BindingDB Ligand

RCSB PDB Ligand

Certificates

Certificate of Analysis(COA)

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3 results found

Lot Number	Certificate Type	Date	Item
D1615042	Certificate of Analysis	Sep 12, 2023	A127268
A1822013	Certificate of Analysis	Jun 08, 2023	A127268
H2230042	Certificate of Analysis	Sep 03, 2022	A127268

Solubility

Solvent:DMSO, Max Conc. mg/mL: 11.31, Max Conc. mM: 25; Solvent:ethanol, Max Conc. mg/mL: 33.94, Max Conc. mM: 75

Refractive Index

1.63

Boil Point(°C)

621.04 °C at 760 mmHg

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