Basic Description

Specifications & Purity	Moligand™, ≥98%(HPLC)
Biochemical and Physiological Mechanisms	Potent negative allosteric modulator of PAR2(IC50= 23 nM); binds to a remote allosteric site outside the helical bundle. Inhibits ERK phosphorylation in 1321N1 cells overexpressing wild-type human PAR2. Highly lipophilic.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	ALLOSTERIC MODULATOR
Mechanism of action	Allosteric modulator of PAR2
Product Description	application： AZ3451 has been used as a protease-activated receptor 2 (PAR-2) antagonist to study the involvement of PAR-2 receptors in factor X activated (FXa)-induced upregulation of the cell adhesion molecules.

Associated Targets(Human)

F2RL1 Tchem Proteinase-activated receptor 2 (3 Activities)

Discover Target: F2RL1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

F2R Tclin Proteinase-activated receptor 1 (1799 Activities)

Discover Target: F2R

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

F2RL3 Tchem Proteinase activated receptor 4 (1491 Activities)

Discover Target: F2RL3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

F2RL1 Tchem Proteinase-activated receptor 2 (703 Activities)

Discover Target: F2RL1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	2-(6-bromo-1,3-benzodioxol-5-yl)-N-(4-cyanophenyl)-1-[(1S)-1-cyclohexylethyl]benzimidazole-5-carboxamide
INCHI	InChI=1S/C30H27BrN4O3/c1-18(20-5-3-2-4-6-20)35-26-12-9-21(30(36)33-22-10-7-19(16-32)8-11-22)13-25(26)34-29(35)23-14-27-28(15-24(23)31)38-17-37-27/h7-15,18,20H,2-6,17H2,1H3,(H,33,36)/t18-/m0/s1
InChi Key	FJAOGFGHTPYADT-SFHVURJKSA-N
Canonical SMILES	CC(C1CCCCC1)N2C3=C(C=C(C=C3)C(=O)NC4=CC=C(C=C4)C#N)N=C2C5=CC6=C(C=C5Br)OCO6
Isomeric SMILES	C[C@@H](C1CCCCC1)N2C3=C(C=C(C=C3)C(=O)NC4=CC=C(C=C4)C#N)N=C2C5=CC6=C(C=C5Br)OCO6
PubChem CID	126961335
MeSH Entry Terms	2-(6-bromobenzo(d)(1,3)dioxol-5-yl)-N-(4-cyanophenyl)-1-(1-cyclohexylethyl)-1Hbenzo(d)imidazole-5-carboxamide;AZ3451
Molecular Weight	571.46

Certificates

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4 results found

Lot Number	Certificate Type	Date	Item
C2222194	Certificate of Analysis	Feb 16, 2022	A286695
C2222204	Certificate of Analysis	Feb 16, 2022	A286695
C2222213	Certificate of Analysis	Feb 16, 2022	A286695
C2222270	Certificate of Analysis	Feb 16, 2022	A286695

Chemical and Physical Properties

Solubility	Solvent:DMSO, Max Conc. mg/mL: 57.15, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 57.15, Max Conc. mM: 100

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SKU	Size	Availability	Price
A286695-5mg	5mg	In stock	$75.90
A286695-10mg	10mg	In stock	$129.90
A286695-25mg	25mg	In stock	$293.90
A286695-50mg	50mg	In stock	$510.90
A286695-100mg	100mg	In stock	$891.90

AZ 3451 - ≥98%(HPLC), high purity , CAS No.2100284-59-9, Allosteric modulator of PAR2