Basic Description

Synonyms	905586-69-8\|AZ-960\|AZ 960\|AZ960\|(S)-5-fluoro-2-((1-(4-fluorophenyl)ethyl)amino)-6-((5-methyl-1H-pyrazol-3-yl)amino)nicotinonitrile\|(S)-5-Fluoro-2-(1-(4-fluorophenyl)ethylamino)-6-(5-methyl-1H-pyrazol-3-ylamino)nicotinonitrile\|M63IS9PTJF\|CHEMBL1774055\|3-Py
Specifications & Purity	98%
Storage Temp	Store at -20°C
Shipped In	Dry ice
Action Type	INHIBITOR
Mechanism of action	Inhibitor of Janus kinase 2

Associated Targets

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

IUPAC Name	5-fluoro-2-[[(1S)-1-(4-fluorophenyl)ethyl]amino]-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyridine-3-carbonitrile
INCHI	InChI=1S/C18H16F2N6/c1-10-7-16(26-25-10)23-18-15(20)8-13(9-21)17(24-18)22-11(2)12-3-5-14(19)6-4-12/h3-8,11H,1-2H3,(H3,22,23,24,25,26)/t11-/m0/s1
InChi Key	SUNXHXDJOIXABJ-NSHDSACASA-N
Canonical SMILES	CC1=CC(=NN1)NC2=C(C=C(C(=N2)NC(C)C3=CC=C(C=C3)F)C#N)F
Isomeric SMILES	CC1=CC(=NN1)NC2=C(C=C(C(=N2)N[C@@H](C)C3=CC=C(C=C3)F)C#N)F
PubChem CID	25099184
Molecular Weight	354.36

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12 results found

Lot Number	Certificate Type	Date	Item
G2304085	Certificate of Analysis	Jun 09, 2023	A129464
G2304089	Certificate of Analysis	Jun 09, 2023	A129464
G2304092	Certificate of Analysis	Jun 09, 2023	A129464
G2304096	Certificate of Analysis	Jun 09, 2023	A129464
G2304098	Certificate of Analysis	Jun 09, 2023	A129464
G2304137	Certificate of Analysis	Jun 09, 2023	A129464
G2304139	Certificate of Analysis	Jun 09, 2023	A129464
G2304140	Certificate of Analysis	Jun 09, 2023	A129464
G2304141	Certificate of Analysis	Jun 09, 2023	A129464
G2304143	Certificate of Analysis	Jun 09, 2023	A129464
G2304146	Certificate of Analysis	Jun 09, 2023	A129464
G2304165	Certificate of Analysis	Jun 09, 2023	A129464

Solubility	DMSO 71 mg/mL Water <1 mg/mL Ethanol 3 mg/mL

1. Gozgit JM, Bebernitz G, Patil P, Ye M, Parmentier J, Wu J, Su N, Wang T, Ioannidis S, Davies A et al.. (2008) Effects of the JAK2 inhibitor, AZ960, on Pim/BAD/BCL-xL survival signaling in the human JAK2 V617F cell line SET-2.. J Biol Chem, 283 (47): (32334-43). [PMID:18775810]

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SKU	Size	Availability	Price
A129464-2mg	2mg	In stock	$197.90
A129464-5mg	5mg	In stock	$344.90
A129464-10mg	10mg	In stock	$532.90
A129464-25mg	25mg	In stock	$1,199.90
A129464-50mg	50mg	In stock	$1,565.90
A129464-100mg	100mg	In stock	$2,818.90