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AZ PFKFB3 26 - ≥98%(HPLC), high purity , CAS No.1704740-52-2
Potent and selective PFKFB3 inhibitor
Basic Description Specifications & Purity ≥98%(HPLC) Biochemical and Physiological Mechanisms Potent and selective PFKFB3 inhibitor (IC50= 0.023 μM). Selective for PFKFB3 over PFKFB2 and PFKFB1 isoforms (IC50values are 0.382 μM and 2.06 μM, respectively). Reduces levels of fructose-1,6-bisphosphate in A549 cells (IC50= 0.343 μM). Exhibits no sign Storage Temp Store at -20°C Shipped In Ice chest + Ice pads
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name (2S)-N-[4-[3-cyano-1-(2-methylpropyl)indol-5-yl]oxyphenyl]pyrrolidine-2-carboxamide INCHI InChI=1S/C24H26N4O2/c1-16(2)14-28-15-17(13-25)21-12-20(9-10-23(21)28)30-19-7-5-18(6-8-19)27-24(29)22-4-3-11-26-22/h5-10,12,15-16,22,26H,3-4,11,14H2,1-2H3,(H,27,29)/t22-/m0/s1 InChi Key OOGHGWKBJXQNEJ-QFIPXVFZSA-N Canonical SMILES CC(C)CN1C=C(C2=C1C=CC(=C2)OC3=CC=C(C=C3)NC(=O)C4CCCN4)C#N Isomeric SMILES CC(C)CN1C=C(C2=C1C=CC(=C2)OC3=CC=C(C=C3)NC(=O)[C@@H]4CCCN4)C#N PubChem CID 118735769 Molecular Weight 402.49
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 40.25, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 40.25, Max Conc. mM: 100
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