Grouped product items

SKU

Size

Availability

Price

Qty

A412213-5mg

5mg

In stock

$78.90

A412213-10mg

10mg

In stock

$117.90

A412213-25mg

25mg

In stock

$265.90

A412213-50mg

50mg

In stock

$355.90

A412213-100mg

100mg

In stock

$533.90

A412213-250mg

250mg

In stock

$1,201.90

Basic Description

Synonyms	AKOS037649295 \| Q27074785 \| SB17497 \| D81581 \| DB13994 \| HY-111052 \| KYDURMHFWXCKMW-UHFFFAOYSA-N \| UNII-KNM216XOUH \| MFCD21337369 \| KNM216XOUH \| AZD 7325 \| AZD 7325; AZD7325 \| 3-CINNOLINECARBOXAMIDE, 4-AMINO-8-(2-FLUORO-6-METHOXYPHENYL)-N-PROPYL- \| GTPL77
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	AZD7325 is a\xa0positive allosteric modulator (PAM) of α2,3\xa0subtype-selective\xa0GABA receptor with pKi of 9.51 and has less efficacy at the α1\xa0and α5\xa0receptor subtypes. AZD7325 is a moderate\xa0CYP1A2\xa0and a potent\xa0CYP3A4\xa0inducer
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	ALLOSTERIC MODULATOR, ANTAGONIST
Mechanism of action	Allosteric modulator of GABA A receptor α2 subunit;Allosteric modulator of GABA A receptor α3 subunit;Antagonist of MT 1 receptor
Product Description	Information AZD7325 is a positive allosteric modulator (PAM) of α2,3 subtype-selective GABA receptor with pKi of 9.51 and has less efficacy at the α1 and α5 receptor subtypes. AZD7325 is a moderate CYP1A2 and a potent CYP3A4 inducer in vitro.

Product Properties

ALogP	3.3

Associated Targets(Human)

GABRA1 Tclin Gamma-aminobutyric acid receptor subunit alpha-1 (1 Activities)

Discover Target: GABRA1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GABRA3 Tclin Gamma-aminobutyric acid receptor subunit alpha-3 (2 Activities)

Discover Target: GABRA3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GABRA5 Tclin Gamma-aminobutyric acid receptor subunit alpha-5 (1 Activities)

Discover Target: GABRA5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GABRA2 Tclin Gamma-aminobutyric acid receptor subunit alpha-2 (3 Activities)

Discover Target: GABRA2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MTNR1A Tclin Melatonin receptor type 1A (1 Activities)

Discover Target: MTNR1A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GABRA1 Tclin GABA receptor alpha-1 subunit (399 Activities)

Discover Target: GABRA1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GABRA5 Tclin GABA receptor alpha-5 subunit (699 Activities)

Discover Target: GABRA5

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GABRA3 Tclin GABA receptor alpha-3 subunit (187 Activities)

Discover Target: GABRA3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GABRA2 Tclin GABA receptor alpha-2 subunit (271 Activities)

Discover Target: GABRA2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)

Discover Target: CYP3A4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Homo sapiens (32628 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

U2OS (164939 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Liver microsomes (16955 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GABRG2 Tclin GABA-A receptor; alpha-3/beta-3/gamma-2 (1250 Activities)

Discover Target: GABRG2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GABRG2 Tclin GABA-A receptor; alpha-2/beta-3/gamma-2 (949 Activities)

Discover Target: GABRG2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Rattus norvegicus (775804 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Gabrg2 GABA-A receptor; alpha-1/beta-2/gamma-2 (554 Activities)

Discover Target: Gabrg2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	488200354
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488200354
IUPAC Name	4-amino-8-(2-fluoro-6-methoxyphenyl)-N-propylcinnoline-3-carboxamide
INCHI	InChI=1S/C19H19FN4O2/c1-3-10-22-19(25)18-16(21)12-7-4-6-11(17(12)23-24-18)15-13(20)8-5-9-14(15)26-2/h4-9H,3,10H2,1-2H3,(H2,21,23)(H,22,25)
InChi Key	KYDURMHFWXCKMW-UHFFFAOYSA-N
Canonical SMILES	CCCNC(=O)C1=NN=C2C(=C1N)C=CC=C2C3=C(C=CC=C3F)OC
Isomeric SMILES	CCCNC(=O)C1=NN=C2C(=C1N)C=CC=C2C3=C(C=CC=C3F)OC
Alternate CAS	942437-37-8
PubChem CID	23581869
MeSH Entry Terms	4-amino-8-(2-fluoro-6-methoxy-phenyl)-N-propylcinnoline-3-carboxamide;AZD7325
Molecular Weight	354.38

Database links

PubChem SID	488200354

Certificates

Certificate of Analysis(COA)

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Find and download the COA for your product by matching the lot number on the packaging.

12 results found

Lot Number	Certificate Type	Date	Item
C2321175	Certificate of Analysis	Jan 05, 2023	A412213
C2321180	Certificate of Analysis	Jan 05, 2023	A412213
C2321226	Certificate of Analysis	Jan 05, 2023	A412213
C2321236	Certificate of Analysis	Jan 05, 2023	A412213
C2321272	Certificate of Analysis	Jan 05, 2023	A412213
C2321293	Certificate of Analysis	Jan 05, 2023	A412213
C2321299	Certificate of Analysis	Jan 05, 2023	A412213
C2321306	Certificate of Analysis	Jan 05, 2023	A412213
C2321312	Certificate of Analysis	Jan 05, 2023	A412213
C2321317	Certificate of Analysis	Jan 05, 2023	A412213
C2321318	Certificate of Analysis	Jan 05, 2023	A412213
C2321321	Certificate of Analysis	Jan 05, 2023	A412213

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Safety and Hazards(GHS)

Pictogram(s)	GHS05, GHS07
Signal	Danger
Hazard Statements	H302:Harmful if swallowed H318:Causes serious eye damage
Precautionary Statements	P280:Wear protective gloves/protective clothing/eye protection/face protection. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P305+P354+P338:IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. P317:Get emergency medical help.

References

1. Alhambra C, Becker C, Blake T, Chang AH, Damewood Jr JR, Daniels T, Dembofsky BT, Gurley DA, Hall JE, Herzog KJ et al.. (2011) Development and SAR of functionally selective allosteric modulators of GABAA receptors.. Bioorg Med Chem, 19 (9): (2927-38). [PMID:21498079] [10.1021/op500134e]

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AZD-7325 - 98%, high purity , CAS No.942437-37-8, Allosteric modulator of GABA A receptor α2 subunit;Allosteric modulator of GABA A receptor α3 subunit;Antagonist of MT 1 receptor

Basic Description

Product Properties

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

Show more⌵

Safety and Hazards(GHS)

Related Documents

References

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator