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AZD-7325 - 98%, high purity , CAS No.942437-37-8, Allosteric modulator of GABA A receptor α2 subunit;Allosteric modulator of GABA A receptor α3 subunit;Antagonist of MT 1 receptor

Moligand™
≥98%

CAS#: 942437-37-8
Formula: C₁₉H₁₉FN₄O₂
Molecular Weight: 354.38
EC Number: 935-772-6
PubChem CID: 23581869
PubChem SID: 488200354

Item Number

A412213

Grouped product items
SKU	Size	Availability	Price
A412213-5mg	5mg	In stock	$78.90
A412213-10mg	10mg	In stock	$117.90
A412213-25mg	25mg	In stock	$265.90
A412213-50mg	50mg	In stock	$355.90
A412213-100mg	100mg	In stock	$533.90
A412213-250mg	250mg	In stock	$1,201.90

View related series

GABAA receptor α2 subunit Allosteric modulator GABAA receptor α3 subunit Allosteric modulator MT1 receptor Antagonist

Basic Description

Synonyms	AZD-7325\|942437-37-8\|4-amino-8-(2-fluoro-6-methoxyphenyl)-N-propylcinnoline-3-carboxamide\|AZD7325\|UNII-KNM216XOUH\|KNM216XOUH\|CHEMBL1783282\|KYDURMHFWXCKMW-UHFFFAOYSA-N\|GTPL7712\|SCHEMBL1962584\|AZD 7325 [WHO-DD]\|AZD 7325\|BCP29554\|EX-A3618\|BDBM50418481\|MFCD21
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	AZD7325 is a\xa0positive allosteric modulator (PAM) of α2,3\xa0subtype-selective\xa0GABA receptor with pKi of 9.51 and has less efficacy at the α1\xa0and α5\xa0receptor subtypes. AZD7325 is a moderate\xa0CYP1A2\xa0and a potent\xa0CYP3A4\xa0inducer
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	ALLOSTERIC MODULATOR, ANTAGONIST
Mechanism of action	Allosteric modulator of GABA A receptor α2 subunit;Allosteric modulator of GABA A receptor α3 subunit;Antagonist of MT 1 receptor
Product Description	Information AZD7325 is a positive allosteric modulator (PAM) of α2,3 subtype-selective GABA receptor with pKi of 9.51 and has less efficacy at the α1 and α5 receptor subtypes. AZD7325 is a moderate CYP1A2 and a potent CYP3A4 inducer in vitro.

Associated Targets

CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

Discover Target: CYP3A4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GABRA1 Tclin Gamma-aminobutyric acid receptor subunit alpha-1 1 Activities

Discover Target: GABRA1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GABRG2 Tclin Gamma-aminobutyric acid receptor subunit gamma-2 0 Activities

Discover Target: GABRG2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GABRA3 Tclin Gamma-aminobutyric acid receptor subunit alpha-3 2 Activities

Discover Target: GABRA3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GABRA5 Tclin Gamma-aminobutyric acid receptor subunit alpha-5 1 Activities

Discover Target: GABRA5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GABRA2 Tclin Gamma-aminobutyric acid receptor subunit alpha-2 3 Activities

Discover Target: GABRA2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MTNR1A Tclin Melatonin receptor type 1A 1 Activities

Discover Target: MTNR1A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

Pubchem Sid	488200354
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488200354
IUPAC Name	4-amino-8-(2-fluoro-6-methoxyphenyl)-N-propylcinnoline-3-carboxamide
INCHI	InChI=1S/C19H19FN4O2/c1-3-10-22-19(25)18-16(21)12-7-4-6-11(17(12)23-24-18)15-13(20)8-5-9-14(15)26-2/h4-9H,3,10H2,1-2H3,(H2,21,23)(H,22,25)
InChi Key	KYDURMHFWXCKMW-UHFFFAOYSA-N
Canonical SMILES	CCCNC(=O)C1=NN=C2C(=C1N)C=CC=C2C3=C(C=CC=C3F)OC
Isomeric SMILES	CCCNC(=O)C1=NN=C2C(=C1N)C=CC=C2C3=C(C=CC=C3F)OC
Alternate CAS	942437-37-8
PubChem CID	23581869
MeSH Entry Terms	4-amino-8-(2-fluoro-6-methoxy-phenyl)-N-propylcinnoline-3-carboxamide;AZD7325
Molecular Weight	354.38

Certificates

Certificate of Analysis(COA)

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12 results found

Lot Number	Certificate Type	Date	Item
C2321175	Certificate of Analysis	Jan 05, 2023	A412213
C2321180	Certificate of Analysis	Jan 05, 2023	A412213
C2321226	Certificate of Analysis	Jan 05, 2023	A412213
C2321236	Certificate of Analysis	Jan 05, 2023	A412213
C2321272	Certificate of Analysis	Jan 05, 2023	A412213
C2321293	Certificate of Analysis	Jan 05, 2023	A412213
C2321299	Certificate of Analysis	Jan 05, 2023	A412213
C2321306	Certificate of Analysis	Jan 05, 2023	A412213
C2321312	Certificate of Analysis	Jan 05, 2023	A412213
C2321317	Certificate of Analysis	Jan 05, 2023	A412213
C2321318	Certificate of Analysis	Jan 05, 2023	A412213
C2321321	Certificate of Analysis	Jan 05, 2023	A412213

Safety and Hazards(GHS)

Pictogram(s)	GHS05, GHS07
Signal	Danger
Hazard Statements	H302:Harmful if swallowed H318:Causes serious eye damage
Precautionary Statements	P280:Wear protective gloves/protective clothing/eye protection/face protection. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P305+P354+P338:IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. P317:Get emergency medical help.

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