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AZD0284 - 98%, high purity , CAS No.2101291-07-8, Agonist of RAR-related orphan receptor-γ

Moligand™

≥98%

CAS#: 2101291-07-8
Formula: C₂₁H₁₈F₆N₂O₅S
Molecular Weight: 524.43
PubChem CID: 129205086

Item Number

A607852

Grouped product items
SKU	Size	Availability	Price
A607852-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	Special Price $11.90 Regular Price $111.90
A607852-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$278.90
A607852-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$283.90
A607852-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$767.90
A607852-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,073.90

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Basic Description

Synonyms	HY-120384 \| compound 20 [PMID: 34464130] \| AZD0284 \| AZD-0284 \| GTPL11711 \| 5G4XF6VU2Y \| BDBM50575029 \| VCH \| 1H-Isoindole-1-carboxamide, 2-acetyl-2,3-dihydro-5-(methylsulfonyl)-N-(4-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)phenyl)-, (1R)- \| CS
Specifications & Purity	Moligand™, ≥98%
Storage Temp	Store at -20°C,Argon charged
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	AGONIST
Mechanism of action	Agonist of RAR-related orphan receptor-γ
Product Description	AZD-0284 is an inverse agonist of the nuclear receptor RORγ. In development for the treatment of plaque psoriasis vulgaris and respiratory tract disorders

Associated Targets(Human)

RORC Tchem Nuclear receptor ROR-gamma (2 Activities)

Discover Target: RORC

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNH2 Tclin HERG (29587 Activities)

Discover Target: KCNH2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)

Discover Target: CYP2D6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)

Discover Target: CYP1A2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)

Discover Target: CYP2C9

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)

Discover Target: CYP2C19

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)

Discover Target: CYP3A4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RORA Tchem Nuclear receptor ROR-alpha (562 Activities)

Discover Target: RORA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Mus musculus (284745 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rorc Nuclear receptor ROR-gamma (89407 Activities)

Discover Target: Rorc

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	(1R)-2-acetyl-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-5-methylsulfonyl-1,3-dihydroisoindole-1-carboxamide
INCHI	InChI=1S/C21H18F6N2O5S/c1-11(30)29-10-12-9-15(35(2,33)34)7-8-16(12)17(29)18(31)28-14-5-3-13(4-6-14)19(32,20(22,23)24)21(25,26)27/h3-9,17,32H,10H2,1-2H3,(H,28,31)/t17-/m1/s1
InChi Key	QYYZXEPEVBXNNA-QGZVFWFLSA-N
Canonical SMILES	CC(=O)N1CC2=C(C1C(=O)NC3=CC=C(C=C3)C(C(F)(F)F)(C(F)(F)F)O)C=CC(=C2)S(=O)(=O)C
Isomeric SMILES	CC(=O)N1CC2=C([C@@H]1C(=O)NC3=CC=C(C=C3)C(C(F)(F)F)(C(F)(F)F)O)C=CC(=C2)S(=O)(=O)C
Alternate CAS	2101291-07-8
PubChem CID	129205086
MeSH Entry Terms	2-acetyl-N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-5-(methylsulfonyl)-2,3-dihydro-1H-isoindole-1-carboxamide;AZD-0284;AZD0284
Molecular Weight	524.43

PubChem CID

129205086

CAS Registry No.

2101291-07-8

RCSB PDB Ligand

VCH

Certificates

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10 results found

Lot Number	Certificate Type	Date	Item
B2427040	Certificate of Analysis	Jan 19, 2024	A607852
B2427041	Certificate of Analysis	Jan 19, 2024	A607852
B2427042	Certificate of Analysis	Jan 19, 2024	A607852
B2427055	Certificate of Analysis	Jan 19, 2024	A607852
B2427056	Certificate of Analysis	Jan 19, 2024	A607852
B2427057	Certificate of Analysis	Jan 19, 2024	A607852
B2427058	Certificate of Analysis	Jan 19, 2024	A607852
B2427062	Certificate of Analysis	Jan 19, 2024	A607852
B2427063	Certificate of Analysis	Jan 19, 2024	A607852
B2427064	Certificate of Analysis	Jan 19, 2024	A607852

References

1. Narjes F, Llinas A, von Berg S, Jirholt J, Lever S, Pehrson R, Collins M, Malmberg M, Svanberg P, Xue Y et al.. (2021) AZD0284, a Potent, Selective, and Orally Bioavailable Inverse Agonist of Retinoic Acid Receptor-Related Orphan Receptor C2. Journal of Medicinal Chemistry, 71 (13): (1755-70). [PMID:34464130] [10.1021/acs.jmedchem.1c01197]

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