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AZD1152 - 98%, high purity , Serine/threonine-protein kinase Aurora-B inhibitor, CAS No.722543-31-9, Serine/threonine-protein kinase Aurora-B inhibitor

≥98%

CAS#: 722543-31-9
Formula: C₂₆H₃₁FN₇O₆P
Molecular Weight: 587.54
PubChem CID: 11497983

Item Number

A126951

Grouped product items
SKU	Size	Availability	Price
A126951-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$16.90
A126951-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$59.90
A126951-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$109.90
A126951-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$199.90
A126951-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$379.90

View related series

aurora kinase A Inhibitor aurora kinase B Inhibitor

Basic Description

Synonyms	2-[ethyl-[3-[4-[[5-[2-(3-fluoroanilino)-2-oxoethyl]-1H-pyrazol-3-yl]amino]quinazolin-7-yl]oxypropyl]amino]ethyl dihydrogen phosphate \| AZD1152 (Barasertib) \| AC-35703 \| CHEBI:167636 \| CS-D0326 \| AKOS040741193 \| barasertibum \| CS-W000582 \| FT-0736007 \| 2-(
Specifications & Purity	98%
Storage Temp	Store at -20°C
Shipped In	Dry ice
Action Type	INHIBITOR
Mechanism of action	Serine/threonine-protein kinase Aurora-B inhibitor

Associated Targets

RAB6A Tchem Ras-related protein Rab-6A 1 Activities

Discover Target: RAB6A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FLT3 Tclin Receptor-type tyrosine-protein kinase FLT3 1 Activities

Discover Target: FLT3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AURKA Tchem Aurora kinase A 1 Activities

Discover Target: AURKA

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AURKB Tchem Aurora kinase B 4 Activities

Discover Target: AURKB

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AURKC Tchem Aurora kinase C 1 Activities

Discover Target: AURKC

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KIT Tclin Mast/stem cell growth factor receptor Kit 2 Activities

Discover Target: KIT

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	2-[ethyl-[3-[4-[[5-[2-(3-fluoroanilino)-2-oxoethyl]-1H-pyrazol-3-yl]amino]quinazolin-7-yl]oxypropyl]amino]ethyl dihydrogen phosphate
INCHI	InChI=1S/C26H31FN7O6P/c1-2-34(10-12-40-41(36,37)38)9-4-11-39-21-7-8-22-23(16-21)28-17-29-26(22)31-24-14-20(32-33-24)15-25(35)30-19-6-3-5-18(27)13-19/h3,5-8,13-14,16-17H,2,4,9-12,15H2,1H3,(H,30,35)(H2,36,37,38)(H2,28,29,31,32,33)
InChi Key	GBJVVSCPOBPEIT-UHFFFAOYSA-N
Canonical SMILES	CCN(CCCOC1=CC2=C(C=C1)C(=NC=N2)NC3=NNC(=C3)CC(=O)NC4=CC(=CC=C4)F)CCOP(=O)(O)O
Isomeric SMILES	CCN(CCCOC1=CC2=C(C=C1)C(=NC=N2)NC3=NNC(=C3)CC(=O)NC4=CC(=CC=C4)F)CCOP(=O)(O)O
PubChem CID	11497983
Molecular Weight	587.54

PubChem CID

11497983

CAS Registry No.

722543-31-9

ChEMBL Ligand

CHEMBL415049

Certificates

Certificate of Analysis(COA)

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10 results found

Lot Number	Certificate Type	Date	Item
F2426096	Certificate of Analysis	Mar 18, 2024	A126951
F2426097	Certificate of Analysis	Mar 18, 2024	A126951
F2426098	Certificate of Analysis	Mar 18, 2024	A126951
F2426099	Certificate of Analysis	Mar 18, 2024	A126951
F2426151	Certificate of Analysis	Mar 18, 2024	A126951
F2426152	Certificate of Analysis	Mar 18, 2024	A126951
F2426153	Certificate of Analysis	Mar 18, 2024	A126951
F2426157	Certificate of Analysis	Mar 18, 2024	A126951
F2426158	Certificate of Analysis	Mar 18, 2024	A126951
F2426159	Certificate of Analysis	Mar 18, 2024	A126951

References

1. Carvajal RD, Tse A, Schwartz GK. (2006) Aurora kinases: new targets for cancer therapy.. Clin Cancer Res, 12 (23): (6869-75). [PMID:17145803]
2. Keen N, Taylor S. (2009) Mitotic drivers--inhibitors of the Aurora B Kinase.. Cancer Metastasis Rev, 28 (1-2): (185-95). [PMID:19189202]
3. Keen N, Taylor S. (2004) Aurora-kinase inhibitors as anticancer agents.. Nat Rev Cancer, 4 (12): (927-36). [PMID:15573114]
4. Andrews PD. (2005) Aurora kinases: shining lights on the therapeutic horizon?. Oncogene, 24 (32): (5005-15). [PMID:16049526]
5. Schwartz GK, Carvajal RD, Midgley R, Rodig SJ, Stockman PK, Ataman O, Wilson D, Das S, Shapiro GI. (2013) Phase I study of barasertib (AZD1152), a selective inhibitor of Aurora B kinase, in patients with advanced solid tumors.. Invest New Drugs, 31 (2): (370-80). [PMID:22661287]

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