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AZD2461 - ≥98%, high purity , CAS No.1174043-16-3

≥98%

CAS#: 1174043-16-3
Formula: C₂₂H₂₂FN₃O₃
Molecular Weight: 395.43
PubChem CID: 44199317

Item Number

A127274

Grouped product items
SKU	Size	Availability	Price
A127274-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$124.90
A127274-25mg	25mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$562.90
A127274-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$567.90

Discover AZD2461 by Aladdin Scientific in ≥98% for only $124.90. Available - in Ligands at Aladdin Scientific. Potent PARP inhibitor Tags: .

Basic Description

Synonyms	AZD2461\|1174043-16-3\|AZD-2461\|4-(4-fluoro-3-(4-methoxypiperidine-1-carbonyl)benzyl)phthalazin-1(2H)-one\|3K288XF5XJ\|AZD 2461 [WHO-DD]\|UNII-3K288XF5XJ\|4-[4-Fluoro-3-[(4-methoxypiperidin-1-yl)carbonyl]benzyl]phthalazin-1(2H)-one\|CHEMBL4098253\|AZD 2461\|4-[[4-
Specifications & Purity	≥98%
Storage Temp	Store at -20°C
Shipped In	Dry ice
Product Description	AZD2461 is a novel PARP inhibitor, which has the potential to avoid the olaparib resistence mediated by Pgp.

Associated Targets

PRAP1 Tchem Proline-rich acidic protein 1 1 Activities

Discover Target: PRAP1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PARP1 Tclin Poly [ADP-ribose] polymerase 1 1 Activities

Discover Target: PARP1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	4-[[4-fluoro-3-(4-methoxypiperidine-1-carbonyl)phenyl]methyl]-2H-phthalazin-1-one
INCHI	InChI=1S/C22H22FN3O3/c1-29-15-8-10-26(11-9-15)22(28)18-12-14(6-7-19(18)23)13-20-16-4-2-3-5-17(16)21(27)25-24-20/h2-7,12,15H,8-11,13H2,1H3,(H,25,27)
InChi Key	HYNBNUYQTQIHJK-UHFFFAOYSA-N
Canonical SMILES	COC1CCN(CC1)C(=O)C2=C(C=CC(=C2)CC3=NNC(=O)C4=CC=CC=C43)F
Isomeric SMILES	COC1CCN(CC1)C(=O)C2=C(C=CC(=C2)CC3=NNC(=O)C4=CC=CC=C43)F
PubChem CID	44199317
Molecular Weight	395.43

PubChem CID

44199317

CAS Registry No.

1174043-16-3

Certificates

Certificate of Analysis(COA)

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2 results found

Lot Number	Certificate Type	Date	Item
L2322065	Certificate of Analysis	Jan 03, 2024	A127274
E1609027	Certificate of Analysis	Oct 16, 2023	A127274

Safety and Hazards(GHS)

Pictogram(s)	GHS08, GHS07
Signal	Warning
Hazard Statements	H373:Causes damage to organs through prolonged or repeated exposure H302:Harmful if swallowed
Precautionary Statements	P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help. P319:Get medical help if you feel unwell.

References

1. Graziani G, Szabó C. (2005) Clinical perspectives of PARP inhibitors.. Pharmacol Res, 52 (1): (109-18). [PMID:15911339]
2. Jaspers JE, Kersbergen A, Boon U, Sol W, van Deemter L, Zander SA, Drost R, Wientjens E, Ji J, Aly A et al.. (2013) Loss of 53BP1 causes PARP inhibitor resistance in Brca1-mutated mouse mammary tumors.. Cancer Discov, 3 (1): (68-81). [PMID:23103855]

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