AZD3293 (Lanabecestat) - ≥99%, high purity , CAS No.1383982-64-6, Inhibitor of beta-secretase 1

Item Number

A276027

Grouped product items
SKU	Size	Availability	Price
A276027-2mg	2mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$137.90
A276027-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$246.90
A276027-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$385.90
A276027-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,088.90

blood-brain barrier (BBB) penetrating, specific BACE-1 inhibitor

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Basic Description

Synonyms	(1r,4r)-4-methoxy-5''-methyl-6'-(5-(prop-1-yn-1-yl)pyridin-3-yl)-3'H-dispiro[cyclohexane-1,2'-indene-1',2''-imidazol]-4''-amine \| Lanabecestat(AZD3293,LY-3314814) \| AZD 3293 \| US8865911, 114 \| HY-100740 \| n-(2-chloroethyl)-pyrrolidine.hydrochloride \| Lana
Specifications & Purity	Moligand™, ≥99%
Biochemical and Physiological Mechanisms	Potent, highly permeable, orally active, blood-brain barrier (BBB) penetrating, specific BACE-1 inhibitor with unique slow off-rate kinetics.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of beta-secretase 1
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Product Describtion: Lanabecestat (AZD3293) is a highly permeable, orally active and blood-brain barrier penetrating BACE1 inhibitor (Ki: 0.4 nM).

Names and Identifiers

INCHI	InChI=1S/C26H28N4O/c1-4-5-18-12-21(16-28-15-18)19-6-7-20-14-25(10-8-22(31-3)9-11-25)26(23(20)13-19)29-17(2)24(27)30-26/h6-7,12-13,15-16,22H,8-11,14H2,1-3H3,(H2,27,30)/t22?,25?,26-/m0/s1
InChi Key	WKDNQONLGXOZRG-BOPKNSRXSA-N
Canonical SMILES	CC#CC1=CC(=CN=C1)C2=CC3=C(CC4(C35N=C(C(=N5)N)C)CCC(CC4)OC)C=C2
Isomeric SMILES	CC#CC1=CC(=CN=C1)C2=CC3=C(CC4([C@]35N=C(C(=N5)N)C)CCC(CC4)OC)C=C2
Alternate CAS	1383984-21-1,1383982-64-6
PubChem CID	67979346
MeSH Entry Terms	4-methoxy-5'-methyl-6'-(5-(prop-1-yn-1-yl)pyridin-3-yl)-3'H-dispiro(cyclohexane-1,2'-inden-1',2'-imidazol)-4'-amine;AZD3293;lanabecestat
Molecular Weight	412.5

References

1. Cebers G, Alexander RC, Haeberlein SB, Han D, Goldwater R, Ereshefsky L, Olsson T, Ye N, Rosen L, Russell M et al.. (2017) AZD3293: Pharmacokinetic and Pharmacodynamic Effects in Healthy Subjects and Patients with Alzheimer's Disease.. J Alzheimers Dis, 55 (3): (1039-1053). [PMID:27767991] [10.1021/op500134e]
2. Eketjäll S, Janson J, Kaspersson K, Bogstedt A, Jeppsson F, Fälting J, Haeberlein SB, Kugler AR, Alexander RC, Cebers G. (2016) AZD3293: A Novel, Orally Active BACE1 Inhibitor with High Potency and Permeability and Markedly Slow Off-Rate Kinetics.. J Alzheimers Dis, 50 (4): (1109-23). [PMID:26890753] [10.1021/op500134e]
3. Sakamoto K, Matsuki S, Matsuguma K, Yoshihara T, Uchida N, Azuma F, Russell M, Hughes G, Haeberlein SB, Alexander RC et al.. (2017) BACE1 Inhibitor Lanabecestat (AZD3293) in a Phase 1 Study of Healthy Japanese Subjects: Pharmacokinetics and Effects on Plasma and Cerebrospinal Fluid Aβ Peptides.. J Clin Pharmacol, 57 (11): (1460-1471). [PMID:28618005] [10.1021/op500134e]

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Basic Description