AZD3293 (Lanabecestat) - ≥99%, high purity , CAS No.1383982-64-6, Inhibitor of beta-secretase 1

Item Number

A276027

Grouped product items
SKU	Size	Availability	Price
A276027-2mg	2mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$137.90
A276027-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$246.90
A276027-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$385.90
A276027-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,088.90

blood-brain barrier (BBB) penetrating, specific BACE-1 inhibitor

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Basic Description

Synonyms	Lanabecestat\|1383982-64-6\|AZD-3293\|LY3314814\|AZD3293\|Lanabecestat [USAN]\|X8SPJ492VF\|Lanabecestat (AZD3293; LY3314814)\|CHEMBL4217620\|LY-3314814\|Lanabecestat (USAN)\|Lanabecestat(AZD3293,LY-3314814)\|(1,4-trans,1'R)-4-methoxy-5''-methyl-6'-(5-(prop-1-yn-1-yl)
Specifications & Purity	≥99%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Action Type	INHIBITOR
Mechanism of action	Inhibitor of beta-secretase 1
Product Description	Product Describtion: Lanabecestat (AZD3293) is a highly permeable, orally active and blood-brain barrier penetrating BACE1 inhibitor (Ki: 0.4 nM).

Names and Identifiers

INCHI	InChI=1S/C26H28N4O/c1-4-5-18-12-21(16-28-15-18)19-6-7-20-14-25(10-8-22(31-3)9-11-25)26(23(20)13-19)29-17(2)24(27)30-26/h6-7,12-13,15-16,22H,8-11,14H2,1-3H3,(H2,27,30)/t22?,25?,26-/m0/s1
InChi Key	WKDNQONLGXOZRG-BOPKNSRXSA-N
Canonical SMILES	CC#CC1=CC(=CN=C1)C2=CC3=C(CC4(C35N=C(C(=N5)N)C)CCC(CC4)OC)C=C2
Isomeric SMILES	CC#CC1=CC(=CN=C1)C2=CC3=C(CC4([C@]35N=C(C(=N5)N)C)CCC(CC4)OC)C=C2
Alternate CAS	1383984-21-1,1383982-64-6
PubChem CID	67979346
MeSH Entry Terms	4-methoxy-5'-methyl-6'-(5-(prop-1-yn-1-yl)pyridin-3-yl)-3'H-dispiro(cyclohexane-1,2'-inden-1',2'-imidazol)-4'-amine;AZD3293;lanabecestat
Molecular Weight	412.5

References

1. Cebers G, Alexander RC, Haeberlein SB, Han D, Goldwater R, Ereshefsky L, Olsson T, Ye N, Rosen L, Russell M et al.. (2017) AZD3293: Pharmacokinetic and Pharmacodynamic Effects in Healthy Subjects and Patients with Alzheimer's Disease.. J Alzheimers Dis, 55 (3): (1039-1053). [PMID:27767991]
2. Eketjäll S, Janson J, Kaspersson K, Bogstedt A, Jeppsson F, Fälting J, Haeberlein SB, Kugler AR, Alexander RC, Cebers G. (2016) AZD3293: A Novel, Orally Active BACE1 Inhibitor with High Potency and Permeability and Markedly Slow Off-Rate Kinetics.. J Alzheimers Dis, 50 (4): (1109-23). [PMID:26890753]
3. Sakamoto K, Matsuki S, Matsuguma K, Yoshihara T, Uchida N, Azuma F, Russell M, Hughes G, Haeberlein SB, Alexander RC et al.. (2017) BACE1 Inhibitor Lanabecestat (AZD3293) in a Phase 1 Study of Healthy Japanese Subjects: Pharmacokinetics and Effects on Plasma and Cerebrospinal Fluid Aβ Peptides.. J Clin Pharmacol, 57 (11): (1460-1471). [PMID:28618005]

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Basic Description