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AZD4320 , CAS No.1357576-48-7, Inhibitor of BCL2 apoptosis regulator;Inhibitor of Bcl-2-like 1
Basic Description Synonyms AZD4320|1357576-48-7|AZD-4320|UNII-LH1ZTY91OR|LH1ZTY91OR|4-(4-((R)-(4'-Chloro(1,1'-biphenyl)-2-yl)hydroxymethyl)-1-piperidinyl)-N-((4-(((1R)-3-((2-hydroxyethyl)methylamino)-1-((phenylthio)methyl)propyl)amino)-3-((trifluoromethyl)sulfonyl)phenyl)sulfonyl)b Grade Moligand™ Action Type INHIBITOR Mechanism of action Inhibitor of BCL2 apoptosis regulator;Inhibitor of Bcl-2-like 1
Names and Identifiers IUPAC Name 4-[4-[(R)-[2-(4-chlorophenyl)phenyl]-hydroxymethyl]piperidin-1-yl]-N-[4-[[(2R)-4-[2-hydroxyethyl(methyl)amino]-1-phenylsulfanylbutan-2-yl]amino]-3-(trifluoromethylsulfonyl)phenyl]sulfonylbenzamide INCHI InChI=1S/C45H48ClF3N4O7S3/c1-52(27-28-54)24-23-35(30-61-37-7-3-2-4-8-37)50-41-20-19-38(29-42(41)62(57,58)45(47,48)49)63(59,60)51-44(56)33-13-17-36(18-14-33)53-25-21-32(22-26-53)43(55)40-10-6-5-9-39(40)31-11-15-34(46)16-12-31/h2-20,29,32,35,43,50,54-55H,21-28,30H2,1H3,(H,51,56)/t35-,43-/m1/s1 InChi Key UNEJSHNDABUZNY-UJNHCCGESA-N Canonical SMILES CN(CCC(CSC1=CC=CC=C1)NC2=C(C=C(C=C2)S(=O)(=O)NC(=O)C3=CC=C(C=C3)N4CCC(CC4)C(C5=CC=CC=C5C6=CC=C(C=C6)Cl)O)S(=O)(=O)C(F)(F)F)CCO Isomeric SMILES CN(CC[C@H](CSC1=CC=CC=C1)NC2=C(C=C(C=C2)S(=O)(=O)NC(=O)C3=CC=C(C=C3)N4CCC(CC4)[C@H](C5=CC=CC=C5C6=CC=C(C=C6)Cl)O)S(=O)(=O)C(F)(F)F)CCO Alternate CAS 1357576-48-7 PubChem CID 86661883 MeSH Entry Terms 4-(4-((R)-(2-(4-chlorophenyl)phenyl)-hydroxymethyl)piperidin-1-yl)-N-(4-(((2R)-4-(2-hydroxyethyl(methyl)amino)-1-phenylsulfanylbutan-2-yl)amino)-3-(trifluoromethylsulfonyl)phenyl)sulfonylbenzamide;AZD4320
References 1. Patterson CM, Balachander SB, Grant I, Pop-Damkov P, Kelly B, McCoull W, Parker J, Giannis M, Hill KJ, Gibbons FD et al. . (2021) Design and optimisation of dendrimer-conjugated Bcl-2/xL inhibitor, AZD0466, with improved therapeutic index for cancer therapy.. Commun Biol, 4 (1): (112). [PMID:33495510 ]
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