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AZD4547 - ≥99%, high purity , CAS No.1035270-39-3, Inhibitor of fibroblast growth factor receptor 1;Inhibitor of fibroblast growth factor receptor 2;Inhibitor of fibroblast growth factor receptor 3;Inhibitor of fibroblast growth factor receptor 4;Inhibitor of Insulin-like growth factor I receptor;Inhibito

Specifications & Purity:  ≥99%
Item Number
A127209
Grouped product items
SKUSizeAvailabilityPrice Qty
A127209-5mg
5mg
In stock
$64.90
A127209-10mg
10mg
In stock
$90.90
A127209-25mg
25mg
In stock
$137.90
A127209-50mg
50mg
In stock
$182.90
A127209-100mg
100mg
In stock
$247.90
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Novel, selective FGFR inhibitor

View related series
fibroblast growth factor receptor 1 Inhibitor fibroblast growth factor receptor 2 Inhibitor fibroblast growth factor receptor 3 Inhibitor fibroblast growth factor receptor 4 Inhibitor Insulin-like growth factor I receptor Inhibitor kinase insert domain receptor Inhibitor

Basic Description

SynonymsAZD4547|1035270-39-3|AZD-4547|AZD 4547|N-(5-(3,5-dimethoxyphenethyl)-1H-pyrazol-3-yl)-4-((3S,5R)-3,5-dimethylpiperazin-1-yl)benzamide|2167OG1EKJ|CHEBI:63453|rel-N-[5-[2-(3,5-Dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-4-[(3R,5S)-3,5-dimethyl-1-piperazinyl]ben
Specifications & Purity≥99%
Storage TempStore at -20°C
Shipped InDry ice
Action TypeINHIBITOR
Mechanism of actionInhibitor of fibroblast growth factor receptor 1;Inhibitor of fibroblast growth factor receptor 2;Inhibitor of fibroblast growth factor receptor 3;Inhibitor of fibroblast growth factor receptor 4;Inhibitor of Insulin-like growth factor I receptor;Inhibito

Associated Targets

FGFR1 Tclin Fibroblast growth factor receptor 1 16 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

FGFR2 Tclin Fibroblast growth factor receptor 2 15 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

FGFR4 Tclin Fibroblast growth factor receptor 4 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

FGFR3 Tclin Fibroblast growth factor receptor 3 12 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

IGF1R Tclin Insulin-like growth factor 1 receptor 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

KDR Tclin Vascular endothelial growth factor receptor 2 4 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-4-[(3S,5R)-3,5-dimethylpiperazin-1-yl]benzamide
INCHI InChI=1S/C26H33N5O3/c1-17-15-31(16-18(2)27-17)22-9-6-20(7-10-22)26(32)28-25-13-21(29-30-25)8-5-19-11-23(33-3)14-24(12-19)34-4/h6-7,9-14,17-18,27H,5,8,15-16H2,1-4H3,(H2,28,29,30,32)/t17-,18+
InChi Key VRQMAABPASPXMW-HDICACEKSA-N
Canonical SMILES CC1CN(CC(N1)C)C2=CC=C(C=C2)C(=O)NC3=NNC(=C3)CCC4=CC(=CC(=C4)OC)OC
Isomeric SMILES C[C@@H]1CN(C[C@@H](N1)C)C2=CC=C(C=C2)C(=O)NC3=NNC(=C3)CCC4=CC(=CC(=C4)OC)OC
PubChem CID 51039095
Molecular Weight 463.57

Certificates

Certificate of Analysis(COA)

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14 results found

Lot NumberCertificate TypeDateItem
J2109154Certificate of AnalysisJul 10, 2023 A127209
J2109184Certificate of AnalysisJul 10, 2023 A127209
J2109186Certificate of AnalysisJul 10, 2023 A127209
F23251419Certificate of AnalysisMay 27, 2023 A127209
F2325154Certificate of AnalysisMay 27, 2023 A127209
F2325155Certificate of AnalysisMay 27, 2023 A127209
F2325156Certificate of AnalysisMay 27, 2023 A127209
F2325161Certificate of AnalysisMay 27, 2023 A127209
F2325162Certificate of AnalysisMay 27, 2023 A127209
B1510013Certificate of AnalysisOct 24, 2022 A127209
K2211114Certificate of AnalysisAug 25, 2022 A127209
K2211115Certificate of AnalysisAug 25, 2022 A127209
K2211116Certificate of AnalysisAug 25, 2022 A127209
K2211117Certificate of AnalysisAug 25, 2022 A127209

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Chemical and Physical Properties

SolubilityDMSO 92 mg/mL (198.45 mM);Water <1 mg/mL (<1 mM);Ethanol <1 mg/mL (<1 mM);

Safety and Hazards(GHS)

Pictogram(s) GHS06,GHS08,GHS07
Signal Danger
Hazard Statements H301,H302,H372
Precautionary Statements P321,P405,P501,P264,P260,P270,P330,P301+P316,P301+P317,P319

Related Documents

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 Specification Sheet

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References

1. O'Brien A et al..  (2022)  FGF1 Signaling Modulates Biliary Injury and Liver Fibrosis in the Mdr2-/- Mouse Model of Primary Sclerosing Cholangitis..  Hepatol Commun,  6  (7): (1574-1588).  [PMID:35271760]
2. Akazawa Y et al..  (2015)  Recruitment of mesenchymal stem cells by stromal cell-derived factor 1a in pulp cells from deciduous teeth..  Int J Mol Med,  36  (2): (442-8).  [PMID:26082290]

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