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AZD4547 - ≥99%, high purity , CAS No.1035270-39-3, Inhibitor of fibroblast growth factor receptor 1;Inhibitor of fibroblast growth factor receptor 2;Inhibitor of fibroblast growth factor receptor 3;Inhibitor of fibroblast growth factor receptor 4;Inhibitor of Insulin-like growth factor I receptor;Inhibito

1 Citations

Moligand™

≥99%

CAS#: 1035270-39-3
Formula: C₂₆H₃₃N₅O₃
Molecular Weight: 463.57
PubChem CID: 51039095

Item Number

A127209

Grouped product items
SKU	Size	Availability	Price
A127209-5mg	5mg	In stock	$64.90
A127209-10mg	10mg	In stock	$90.90
A127209-25mg	25mg	In stock	$137.90
A127209-50mg	50mg	In stock	$182.90
A127209-100mg	100mg	In stock	$247.90

Novel, selective FGFR inhibitor

View related series

FGFR fibroblast growth factor receptor 1 Inhibitor fibroblast growth factor receptor 2 Inhibitor fibroblast growth factor receptor 3 Inhibitor fibroblast growth factor receptor 4 Inhibitor Insulin-like growth factor I receptor Inhibitor kinase insert domain receptor Inhibitor Protein Tyrosine Kinase/RTK

Basic Description

Synonyms	J-000994 \| N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-4-[(3R,5S)-3,5-dimethylpiperazin-1-yl]benzamide \| NSC799346 \| NSC-799346 \| AZD 4547 \| J-524217 \| KB-74810 \| MFCD22580423 \| NCGC00346713-05 \| N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2H-pyrazol-3-y
Specifications & Purity	Moligand™, ≥99%
Biochemical and Physiological Mechanisms	AZD4547 is a novel selective FGFR inhibitor targeting FGFR1, FGFR2, and FGFR3. AZD4547 treatment potently inhibits FGFR and MAPK phosphorylation in tumor cell lines in a dose-dependent manner.Novel, selective\xa0inhibitor\xa0of the FGFR1, 2, and 3 tyrosin
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of fibroblast growth factor receptor 1;Inhibitor of fibroblast growth factor receptor 2;Inhibitor of fibroblast growth factor receptor 3;Inhibitor of fibroblast growth factor receptor 4;Inhibitor of Insulin-like growth factor I receptor;Inhibito
Product Description	AZD4547 is a novel selective FGFR inhibitor targeting FGFR1/2/3 with IC50 of 0.2 nM/2.5 nM/1.8 nM, weaker activity against FGFR4, VEGFR2(KDR), and little activity observed against IGFR, CDK2, and p38. Phase 2/3. A novel selective FGFR inhibitor targeting FGFR1, FGFR2, and FGFR3.

Associated Targets(Human)

FGFR1 Tclin Fibroblast growth factor receptor 1 (16 Activities)

Discover Target: FGFR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FGFR2 Tclin Fibroblast growth factor receptor 2 (15 Activities)

Discover Target: FGFR2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FGFR4 Tclin Fibroblast growth factor receptor 4 (1 Activities)

Discover Target: FGFR4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FGFR3 Tclin Fibroblast growth factor receptor 3 (12 Activities)

Discover Target: FGFR3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

IGF1R Tclin Insulin-like growth factor 1 receptor (1 Activities)

Discover Target: IGF1R

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KDR Tclin Vascular endothelial growth factor receptor 2 (4 Activities)

Discover Target: KDR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-4-[(3S,5R)-3,5-dimethylpiperazin-1-yl]benzamide
INCHI	InChI=1S/C26H33N5O3/c1-17-15-31(16-18(2)27-17)22-9-6-20(7-10-22)26(32)28-25-13-21(29-30-25)8-5-19-11-23(33-3)14-24(12-19)34-4/h6-7,9-14,17-18,27H,5,8,15-16H2,1-4H3,(H2,28,29,30,32)/t17-,18+
InChi Key	VRQMAABPASPXMW-HDICACEKSA-N
Canonical SMILES	CC1CN(CC(N1)C)C2=CC=C(C=C2)C(=O)NC3=NNC(=C3)CCC4=CC(=CC(=C4)OC)OC
Isomeric SMILES	C[C@@H]1CN(C[C@@H](N1)C)C2=CC=C(C=C2)C(=O)NC3=NNC(=C3)CCC4=CC(=CC(=C4)OC)OC
PubChem CID	51039095
Molecular Weight	463.57

Database links

PubChem CID	51039095
CAS Registry No.	1035270-39-3
ChEBI	CHEBI:63453
RCSB PDB Ligand	66T
Reactome Reaction	R-HSA-2077420, R-HSA-2077424, R-HSA-2023462, R-HSA-2029992
Reactome Drug	R-ALL-2038886

Certificates

Certificate of Analysis(COA)

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Find and download the COA for your product by matching the lot number on the packaging.

14 results found

Lot Number	Certificate Type	Date	Item
K2211114	Certificate of Analysis	Aug 22, 2024	A127209
K2211115	Certificate of Analysis	Aug 22, 2024	A127209
K2211116	Certificate of Analysis	Aug 22, 2024	A127209
J2109154	Certificate of Analysis	Jul 10, 2023	A127209
J2109184	Certificate of Analysis	Jul 10, 2023	A127209
J2109186	Certificate of Analysis	Jul 10, 2023	A127209
F23251419	Certificate of Analysis	May 27, 2023	A127209
F2325154	Certificate of Analysis	May 27, 2023	A127209
F2325155	Certificate of Analysis	May 27, 2023	A127209
F2325156	Certificate of Analysis	May 27, 2023	A127209
F2325161	Certificate of Analysis	May 27, 2023	A127209
F2325162	Certificate of Analysis	May 27, 2023	A127209
B1510013	Certificate of Analysis	Oct 24, 2022	A127209
K2211117	Certificate of Analysis	Aug 25, 2022	A127209

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Chemical and Physical Properties

Solubility	DMSO 92 mg/mL (198.45 mM);Water <1 mg/mL (<1 mM);Ethanol <1 mg/mL (<1 mM);

Safety and Hazards(GHS)

Pictogram(s)	GHS06, GHS08, GHS07
Signal	Danger
Hazard Statements	H301:Toxic if swallowed H302:Harmful if swallowed H372:Causes damage to organs through prolonged or repeated exposure
Precautionary Statements	P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P301+P317:IF SWALLOWED: Get medical help. P319:Get medical help if you feel unwell.

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Yanran Bi, Ruiling Zheng, Jiahao Hu, Ruiqing Shi, Junfeng Shi, Yutao Wang, Peng Wang, Wenyi Jiang, Gyudong Kim, Zhiguo Liu, Xiaokun Li, Li Lin. (2023) A novel FGFR1 inhibitor CYY292 suppresses tumor progression, invasion, and metastasis of glioblastoma by inhibiting the Akt/GSK3β/snail signaling axis. Genes & Diseases, [PMID:37588207] [10.1016/j.gendis.2023.02.035]

References

1. O'Brien A et al.. (2022) FGF1 Signaling Modulates Biliary Injury and Liver Fibrosis in the Mdr2-/- Mouse Model of Primary Sclerosing Cholangitis.. Hepatol Commun, 6 (7): (1574-1588). [PMID:35271760]
2. Akazawa Y et al.. (2015) Recruitment of mesenchymal stem cells by stromal cell-derived factor 1a in pulp cells from deciduous teeth.. Int J Mol Med, 36 (2): (442-8). [PMID:26082290]
3. Yanran Bi, Ruiling Zheng, Jiahao Hu, Ruiqing Shi, Junfeng Shi, Yutao Wang, Peng Wang, Wenyi Jiang, Gyudong Kim, Zhiguo Liu, Xiaokun Li, Li Lin. (2023) A novel FGFR1 inhibitor CYY292 suppresses tumor progression, invasion, and metastasis of glioblastoma by inhibiting the Akt/GSK3β/snail signaling axis. Genes & Diseases, [PMID:37588207] [10.1016/j.gendis.2023.02.035]

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