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AZD4877 , Kinesin-like protein 1 inhibitor, CAS No.1176760-49-8, Kinesin-like protein 1 inhibitor
Basic Description
| Synonyms | AZD-4877 | AZD4877 | 1176760-49-8 | AZD 4877 | CHEMBL1829433 | 19ORU63E06 | 758722-49-5 | N-(3-aminopropyl)-N-(1-(5-benzyl-3-methyl-4-oxo-4,5-dihydroisothiazolo[5,4-d]pyrimidin-6-yl)-2-methylpropyl)-4-methylbenzamide | n-(3-aminopropyl)-n-[1-(5-benzyl-3-methyl-4-oxo-4,5- |
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| Specifications & Purity | Moligand™ |
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| Grade | Moligand™ |
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| Action Type | INHIBITOR |
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| Mechanism of action | Kinesin-like protein 1 inhibitor |
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Associated Targets(Human)
Associated Targets(non-human)
Names and Identifiers
| IUPAC Name | N-(3-aminopropyl)-N-[1-(5-benzyl-3-methyl-4-oxo-[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-2-methylpropyl]-4-methylbenzamide |
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| INCHI | InChI=1S/C28H33N5O2S/c1-18(2)24(32(16-8-15-29)27(34)22-13-11-19(3)12-14-22)25-30-26-23(20(4)31-36-26)28(35)33(25)17-21-9-6-5-7-10-21/h5-7,9-14,18,24H,8,15-17,29H2,1-4H3 |
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| InChi Key | SMFXSYMLJDHGIE-UHFFFAOYSA-N |
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| Canonical SMILES | CC1=CC=C(C=C1)C(=O)N(CCCN)C(C2=NC3=C(C(=NS3)C)C(=O)N2CC4=CC=CC=C4)C(C)C |
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| Isomeric SMILES | CC1=CC=C(C=C1)C(=O)N(CCCN)C(C2=NC3=C(C(=NS3)C)C(=O)N2CC4=CC=CC=C4)C(C)C |
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| Alternate CAS | 1176760-49-8 |
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| PubChem CID | 10368812 |
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| MeSH Entry Terms | AZD 4877;AZD-4877;AZD4877;N-(3-aminopropyl)-N-(1-(5-benzyl-3-methyl-4-oxo-(1,2)thiazolo(5,4-d)pyrimidin-6-yl)-2-methylpropyl)-4-methylbenzamide |
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References
| 1. Theoclitou ME, Aquila B, Block MH, Brassil PJ, Castriotta L, Code E, Collins MP, Davies AM, Deegan T, Ezhuthachan J et al.. (2011) Discovery of (+)-N-(3-aminopropyl)-N-[1-(5-benzyl-3-methyl-4-oxo-[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-2-methylpropyl]-4-methylbenzamide (AZD4877), a kinesin spindle protein inhibitor and potential anticancer agent.. J Med Chem, 54 (19): (6734-50). [PMID:21899292] |
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