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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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A129380-1mg | 1mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $16.90 | |
A129380-5mg | 5mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $64.90 | |
A129380-10mg | 10mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $97.90 | |
A129380-50mg | 50mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $205.90 |
Synonyms | 4-AMINOmethylbenZAMIDINE dihydrochloride | BCP9000357 | GTPL7717 | AS-17066 | BCPP000365 | Sapitinib [INN] | s2192 | AZD 8931 | BDBM50437353 | DB12183 | NCGC00346573-05 | NSC758005 | NSC-758005 | 1-boc-2-(aminomethyl)-pyrrolidine | AZD-8931(Sapitinib) | D |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | AZD8931 is an ATP competitive and reversible inhibitor of EGFR (ErbB-1), Neu (ErbB-2) and ErbB-3 (the IC50 values are 4 nM, 3 nM and 4 nM, respectively). |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Epidermal growth factor receptor erbB1 inhibitor |
Note | 卖完停产,不再备货 |
Product Description | AZD8931 is a reversible, ATP competitive inhibitor of EGFR, ErbB2 and ErbB3 with IC50 of 4 nM, 3 nM and 4 nM, more potent than Gefitinib or Lapatinib against NSCLC cell, 100-fold more selective for the ErbB family than MNK1 and Flt. |
ALogP | 4 |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 2-[4-[4-(3-chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]oxypiperidin-1-yl]-N-methylacetamide |
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INCHI | InChI=1S/C23H25ClFN5O3/c1-26-21(31)12-30-8-6-14(7-9-30)33-20-10-15-18(11-19(20)32-2)27-13-28-23(15)29-17-5-3-4-16(24)22(17)25/h3-5,10-11,13-14H,6-9,12H2,1-2H3,(H,26,31)(H,27,28,29) |
InChi Key | DFJSJLGUIXFDJP-UHFFFAOYSA-N |
Canonical SMILES | CNC(=O)CN1CCC(CC1)OC2=C(C=C3C(=C2)C(=NC=N3)NC4=C(C(=CC=C4)Cl)F)OC |
Isomeric SMILES | CNC(=O)CN1CCC(CC1)OC2=C(C=C3C(=C2)C(=NC=N3)NC4=C(C(=CC=C4)Cl)F)OC |
PubChem CID | 11488320 |
Molecular Weight | 473.93 |
PubChem CID | 11488320 |
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ChEMBL Ligand | CHEMBL2408045 |
CAS Registry No. | 848942-61-0 |
Reactome Reaction | R-HSA-9652264, R-HSA-9665121, R-HSA-9665304 |
Reactome Drug | R-ALL-9649894 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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D1510062 | Certificate of Analysis | Aug 07, 2024 | A129380 |
Solubility | Soluble in DMSO (40 mg/ml), water (<1 mg/ml at 25 °C), and ethanol (<1 mg/ml at 25 °C). |
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Pictogram(s) | GHS08, GHS07 |
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Signal | Danger |
Hazard Statements | H302:Harmful if swallowed H372:Causes damage to organs through prolonged or repeated exposure H361:Suspected of damaging fertility or the unborn child |
Precautionary Statements | P280:Wear protective gloves/protective clothing/eye protection/face protection. P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. P319:Get medical help if you feel unwell. |
1. Mengwei Zhang, Wanyue Liu, Qian Qu, Mingjing Ke, Zhenyan Zhang, Zhigao Zhou, Tao Lu, Haifeng Qian. (2020) Metabolomic modulations in a freshwater microbial community exposed to the fungicide azoxystrobin. Journal of Environmental Sciences, 97 (102). [PMID:32933724] [10.1016/j.jes.2020.04.013] |
2. Lu Tao, Zhou Zhigao, Zhang Qi, Zhang Zhenyan, Qian Haifeng. (2019) Ecotoxicological Effects of Fungicides Azoxystrobin and Pyraclostrobin on Freshwater Aquatic Bacterial Communities. BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY, 103 (5): (683-688). [PMID:31471659] [10.1007/s00128-019-02706-x] |
3. Qi Zhang, Dong Zhu, Jing Ding, Fei Zheng, Shuyidan Zhou, Tao Lu, Yong-Guan Zhu, Haifeng Qian. (2019) The fungicide azoxystrobin perturbs the gut microbiota community and enriches antibiotic resistance genes in Enchytraeus crypticus. ENVIRONMENT INTERNATIONAL, 131 (104965). [PMID:31284112] [10.1016/j.envint.2019.104965] |
4. Xiaochang Liu, Peng Quan, Shanshan Li, Chao Liu, Yuan Zhao, Yongshan Zhao, Liang Fang. (2017) Time dependence of the enhancement effect of chemical enhancers: Molecular mechanisms of enhancing kinetics. JOURNAL OF CONTROLLED RELEASE, 248 (33). [PMID:28088574] [10.1016/j.jconrel.2017.01.017] |
1. Barlaam B, Anderton J, Ballard P, Bradbury RH, Hennequin LF, Hickinson DM, Kettle JG, Kirk G, Klinowska T, Lambert-van der Brempt C et al.. (2013) Discovery of AZD8931, an Equipotent, Reversible Inhibitor of Signaling by EGFR, HER2, and HER3 Receptors.. ACS Med Chem Lett, 4 (8): (742-6). [PMID:24900741] [10.1021/op500134e] |
2. Mengwei Zhang, Wanyue Liu, Qian Qu, Mingjing Ke, Zhenyan Zhang, Zhigao Zhou, Tao Lu, Haifeng Qian. (2020) Metabolomic modulations in a freshwater microbial community exposed to the fungicide azoxystrobin. Journal of Environmental Sciences, 97 (102). [PMID:32933724] [10.1016/j.jes.2020.04.013] |
3. Lu Tao, Zhou Zhigao, Zhang Qi, Zhang Zhenyan, Qian Haifeng. (2019) Ecotoxicological Effects of Fungicides Azoxystrobin and Pyraclostrobin on Freshwater Aquatic Bacterial Communities. BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY, 103 (5): (683-688). [PMID:31471659] [10.1007/s00128-019-02706-x] |
4. Qi Zhang, Dong Zhu, Jing Ding, Fei Zheng, Shuyidan Zhou, Tao Lu, Yong-Guan Zhu, Haifeng Qian. (2019) The fungicide azoxystrobin perturbs the gut microbiota community and enriches antibiotic resistance genes in Enchytraeus crypticus. ENVIRONMENT INTERNATIONAL, 131 (104965). [PMID:31284112] [10.1016/j.envint.2019.104965] |
5. Xiaochang Liu, Peng Quan, Shanshan Li, Chao Liu, Yuan Zhao, Yongshan Zhao, Liang Fang. (2017) Time dependence of the enhancement effect of chemical enhancers: Molecular mechanisms of enhancing kinetics. JOURNAL OF CONTROLLED RELEASE, 248 (33). [PMID:28088574] [10.1016/j.jconrel.2017.01.017] |