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Azelaic acid - 10mM in DMSO, high purity , CAS No.123-99-9

Item Number
A421035
Grouped product items
SKUSizeAvailabilityPrice Qty
A421035-1ml
1ml
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$27.90

5α reductase inhibitor. PPARγ activator.

Basic Description

Synonymsazelaic acid | NONANEDIOIC ACID | 123-99-9 | Finacea | Anchoic acid | Azelex | Lepargylic acid | 1,7-Heptanedicarboxylic acid | Skinoren | 1,9-Nonanedioic acid | Heptanedicarboxylic acid | n-Nonanedioic acid | Emerox 1110 | Emerox 1144 | azelate | acide azelaique | acidum azelaicum | Fine
Specifications & PurityMoligand™, 10mM in DMSO
Biochemical and Physiological Mechanisms5α reductase inhibitor. PPARγ activator. Competitively inhibits tyrosinase and thioredoxin reductase (K i values are 3 mM and 13 μM respectively). Cytotoxin to melanocytes. Reduces skin hyperpigmentation. Induces salicylic acid accumulation in plants.
Storage TempStore at -80°C
Shipped InIce chest + Ice pads
GradeMoligand™
Product Description

Azelaic acid is a dicarboxylic acid that exhibits anti-inflammatory activity. It is known for it’s anti acne activity in vitro. Azelaic acid directly inhibits kallikrein 5 (KLK5), downregulating expression of KLK5, toll-like receptor 2 (TLR 2), and cathelicidin, and suppresses activity of serine proteases in vitro, in vivo, and in clinical settings. In PUFA-treated fibroblasts, azelaic acid decreases generation of ROS and upregulates expression of antioxidative enzymes, inhibiting cell damage; agonist activity at PPARν is thought to drive these effects. Azelaic acid also inhibits proliferation of melanocytes. This compound displays antiacne and anticancer potential as well, inhibiting the proliferation of cutaneous melanoma due to suppression of mitochondrial oxidoreductive activity and DNA synthesis.
An antiinflammatory compound

Product Properties

ALogP1.6

Associated Targets(Human)

ESR1 Tclin Estrogen receptor alpha (17718 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NR3C1 Tclin Glucocorticoid receptor (14987 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PGR Tclin Progesterone receptor (8562 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRB2 Tclin Beta-2 adrenergic receptor (11824 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRB1 Tclin Beta-1 adrenergic receptor (6630 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA2A Tclin Alpha-2a adrenergic receptor (9450 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AR Tclin Androgen Receptor (11781 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD2 Tclin Dopamine D2 receptor (23596 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GABRA1 Tclin GABA receptor alpha-1 subunit (399 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TSHR Tclin Thyroid stimulating hormone receptor (29986 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MAOA Tclin Monoamine oxidase A (11911 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CNR1 Tclin Cannabinoid CB1 receptor (20913 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD1 Tclin Dopamine D1 receptor (9720 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTGS1 Tclin Cyclooxygenase-1 (9233 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A2 Tclin Norepinephrine transporter (10102 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HRH2 Tclin Histamine H2 receptor (5428 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR2A Tclin Serotonin 2a (5-HT2a) receptor (14758 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR2C Tclin Serotonin 2c (5-HT2c) receptor (11471 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AVPR2 Tclin Vasopressin V2 receptor (2912 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADORA1 Tclin Adenosine A1 receptor (17603 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AGTR1 Tclin Type-1 angiotensin II receptor (5176 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A4 Tclin Serotonin transporter (12625 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA1A Tclin Alpha-1a adrenergic receptor (8359 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTGS2 Tclin Cyclooxygenase-2 (13999 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HRH1 Tclin Histamine H1 receptor (7573 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OPRM1 Tclin Mu opioid receptor (19785 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD3 Tclin Dopamine D3 receptor (14368 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AVPR1A Tclin Vasopressin V1a receptor (5412 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OPRD1 Tclin Delta opioid receptor (15096 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OPRK1 Tclin Kappa opioid receptor (16155 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR3A Tclin Serotonin 3a (5-HT3a) receptor (3366 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A3 Tclin Dopamine transporter (10535 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GRIN1 Tclin Glutamate (NMDA) receptor subunit zeta 1 (122 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KCNH2 Tclin HERG (29587 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CACNA1C Tclin Voltage-gated L-type calcium channel alpha-1C subunit (766 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PDE3A Tclin Phosphodiesterase 3A (3309 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC29A1 Tclin Equilibrative nucleoside transporter 1 (1711 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA2B Tclin Alpha-2b adrenergic receptor (4412 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA2C Tclin Alpha-2c adrenergic receptor (4876 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM3 Tclin Muscarinic acetylcholine receptor M3 (7750 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR2B Tclin Serotonin 2b (5-HT2b) receptor (10323 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TBXA2R Tclin Thromboxane A2 receptor (5717 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADORA2A Tclin Adenosine A2a receptor (16305 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADORA3 Tchem Adenosine A3 receptor (15931 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BDKRB2 Tclin Bradykinin B2 receptor (3970 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRNA4 Tclin Neuronal acetylcholine receptor protein alpha-4 subunit (1265 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ARSA Tbio Cerebroside-sulfatase (655 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

ampC Beta-lactamase AmpC (62480 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mc4r Melanocortin receptor 4 (1205 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Npy1r Neuropeptide Y receptor type 1 (8 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cckar Cholecystokinin A receptor (90 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Pde4d Phosphodiesterase 4D (4 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
pfk 6-phospho-1-fructokinase (7870 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ffp 4'-phosphopantetheinyl transferase ffp (24982 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
FTL Ferritin light chain (43324 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences
Estrogen receptor alpha agonistAGONISTALA206Estrogen receptor alphaSINGLE PROTEINHomo sapiens

PubMed: [1]


Estrogen receptor alpha modulatorMODULATORALA206Estrogen receptor alphaSINGLE PROTEINHomo sapiens

DailyMed: [1]


PubMed: [1]


Wikipedia: [1]


Estrogen receptor alpha agonistAGONISTALA206Estrogen receptor alphaSINGLE PROTEINHomo sapiens

PubMed: [1]


Estrogen receptor alpha agonistAGONISTALA206Estrogen receptor alphaSINGLE PROTEINHomo sapiens

DailyMed: [1]


Wikipedia: [1]


Estrogen receptor alpha agonistAGONISTALA206Estrogen receptor alphaSINGLE PROTEINHomo sapiens

DailyMed: [1]


Wikipedia: [1]


Estrogen receptor alpha agonistAGONISTALA206Estrogen receptor alphaSINGLE PROTEINHomo sapiens

DailyMed: [1]


Estrogen receptor alpha modulatorMODULATORALA206Estrogen receptor alphaSINGLE PROTEINHomo sapiens

FDA: [1]


Wikipedia: [1]


Estrogen receptor alpha agonistAGONISTALA206Estrogen receptor alphaSINGLE PROTEINHomo sapiens

ISBN: [1]


Estrogen receptor alpha agonistAGONISTALA206Estrogen receptor alphaSINGLE PROTEINHomo sapiens

ISBN: [1]


PubMed: [1]


Estrogen receptor alpha agonistAGONISTALA206Estrogen receptor alphaSINGLE PROTEINHomo sapiens

DailyMed: [1]


Wikipedia: [1]


Names and Identifiers

IUPAC Name nonanedioic acid
INCHI InChI=1S/C9H16O4/c10-8(11)6-4-2-1-3-5-7-9(12)13/h1-7H2,(H,10,11)(H,12,13)
InChi Key BDJRBEYXGGNYIS-UHFFFAOYSA-N
Canonical SMILES C(CCCC(=O)O)CCCC(=O)O
Isomeric SMILES C(CCCC(=O)O)CCCC(=O)O
WGK Germany 1
RTECS CM1980000
PubChem CID 2266
Molecular Weight 188.22
Beilstein 1101094

Certificates

C of A & Other Certificates

Chemical and Physical Properties

SensitivityMoisture sensitive.
Refractive Index1.4303
Flash Point(°F)410 °F
Flash Point(°C)210 °C
Boil Point(°C)286°C
Melt Point(°C)109-111°C

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

Precautionary Statements

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P264:Wash hands [and …] thoroughly after handling.

P362+P364:Take off contaminated clothing and wash it before reuse.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

WGK Germany 1
RTECS CM1980000

Related Documents

Citations of This Product(6)

1. Suleixin Yang, Ka Hong Wong, Peng Hua, Chengwei He, Hua Yu, Dan Shao, Zhi Shi, Meiwan Chen.  (2022)  ROS-responsive fluorinated polyethyleneimine vector to co-deliver shMTHFD2 and shGPX4 plasmids induces ferroptosis and apoptosis for cancer therapy.  Acta Biomaterialia,  140  (492).  [PMID:34879292] [10.1016/j.actbio.2021.11.042]
2. Qi Jing, Jin Feiyang, You Yuchan, Du Yan, Liu Di, Xu Xiaoling, Wang Jun, Zhu Luwen, Chen Minjiang, Shu Gaofeng, Wu Liming, Ji Jiansong, Du Yongzhong.  (2021)  Synergistic effect of tumor chemo-immunotherapy induced by leukocyte-hitchhiking thermal-sensitive micelles.  Nature Communications,  12  (1): (1-17).  [PMID:34362890] [10.1038/s41467-021-24902-2]
3. Jiujiang Ji, Guo Chen, Jun Zhao.  (2019)  Preparation and characterization of amino/thiol bifunctionalized magnetic nanoadsorbent and its application in rapid removal of Pb (II) from aqueous system.  JOURNAL OF HAZARDOUS MATERIALS,  368  (255).  [PMID:30684763] [10.1016/j.jhazmat.2019.01.035]
4. Gang-Gang Yang, Hang Zhang, Dong-Yang Zhang, Qian Cao, Jing Yang, Liang-Nian Ji, Zong-Wan Mao.  (2018)  Cancer-specific chemotherapeutic strategy based on the vitamin K3 mediated ROS regenerative feedback and visualized drug release in vivo.  BIOMATERIALS,  185  (73).  [PMID:30227273] [10.1016/j.biomaterials.2018.08.065]
5. Shuai Zhang, Na Sha, Zhe Zhao.  (2017)  Surface modification of α-Al2O3 with dicarboxylic acids for the preparation of UV-curable ceramic suspensions.  JOURNAL OF THE EUROPEAN CERAMIC SOCIETY,  37  (1607).  [PMID:] [10.1016/j.jeurceramsoc.2016.12.013]
6. Zhijuan Sun, Xiao Wang, Fei Guo, Chunyue Jiang, Qinmin Pan.  (2016)  Isothermal and nonisothermal crystallization kinetics of bio-sourced nylon 69.  CHINESE JOURNAL OF CHEMICAL ENGINEERING,  24  (638).  [PMID:] [10.1016/j.cjche.2015.12.021]

References

1. Suleixin Yang, Ka Hong Wong, Peng Hua, Chengwei He, Hua Yu, Dan Shao, Zhi Shi, Meiwan Chen.  (2022)  ROS-responsive fluorinated polyethyleneimine vector to co-deliver shMTHFD2 and shGPX4 plasmids induces ferroptosis and apoptosis for cancer therapy.  Acta Biomaterialia,  140  (492).  [PMID:34879292] [10.1016/j.actbio.2021.11.042]
2. Qi Jing, Jin Feiyang, You Yuchan, Du Yan, Liu Di, Xu Xiaoling, Wang Jun, Zhu Luwen, Chen Minjiang, Shu Gaofeng, Wu Liming, Ji Jiansong, Du Yongzhong.  (2021)  Synergistic effect of tumor chemo-immunotherapy induced by leukocyte-hitchhiking thermal-sensitive micelles.  Nature Communications,  12  (1): (1-17).  [PMID:34362890] [10.1038/s41467-021-24902-2]
3. Jiujiang Ji, Guo Chen, Jun Zhao.  (2019)  Preparation and characterization of amino/thiol bifunctionalized magnetic nanoadsorbent and its application in rapid removal of Pb (II) from aqueous system.  JOURNAL OF HAZARDOUS MATERIALS,  368  (255).  [PMID:30684763] [10.1016/j.jhazmat.2019.01.035]
4. Gang-Gang Yang, Hang Zhang, Dong-Yang Zhang, Qian Cao, Jing Yang, Liang-Nian Ji, Zong-Wan Mao.  (2018)  Cancer-specific chemotherapeutic strategy based on the vitamin K3 mediated ROS regenerative feedback and visualized drug release in vivo.  BIOMATERIALS,  185  (73).  [PMID:30227273] [10.1016/j.biomaterials.2018.08.065]
5. Shuai Zhang, Na Sha, Zhe Zhao.  (2017)  Surface modification of α-Al2O3 with dicarboxylic acids for the preparation of UV-curable ceramic suspensions.  JOURNAL OF THE EUROPEAN CERAMIC SOCIETY,  37  (1607).  [PMID:] [10.1016/j.jeurceramsoc.2016.12.013]
6. Zhijuan Sun, Xiao Wang, Fei Guo, Chunyue Jiang, Qinmin Pan.  (2016)  Isothermal and nonisothermal crystallization kinetics of bio-sourced nylon 69.  CHINESE JOURNAL OF CHEMICAL ENGINEERING,  24  (638).  [PMID:] [10.1016/j.cjche.2015.12.021]

Solution Calculators