Determine the necessary mass, volume, or concentration for preparing a solution.
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SKU | Size | Availability | Price | Qty |
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A421035-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $27.90 |
5α reductase inhibitor. PPARγ activator.
Synonyms | azelaic acid | NONANEDIOIC ACID | 123-99-9 | Finacea | Anchoic acid | Azelex | Lepargylic acid | 1,7-Heptanedicarboxylic acid | Skinoren | 1,9-Nonanedioic acid | Heptanedicarboxylic acid | n-Nonanedioic acid | Emerox 1110 | Emerox 1144 | azelate | acide azelaique | acidum azelaicum | Fine |
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Specifications & Purity | Moligand™, 10mM in DMSO |
Biochemical and Physiological Mechanisms | 5α reductase inhibitor. PPARγ activator. Competitively inhibits tyrosinase and thioredoxin reductase (K i values are 3 mM and 13 μM respectively). Cytotoxin to melanocytes. Reduces skin hyperpigmentation. Induces salicylic acid accumulation in plants. |
Storage Temp | Store at -80°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Product Description | Azelaic acid is a dicarboxylic acid that exhibits anti-inflammatory activity. It is known for it’s anti acne activity in vitro. Azelaic acid directly inhibits kallikrein 5 (KLK5), downregulating expression of KLK5, toll-like receptor 2 (TLR 2), and cathelicidin, and suppresses activity of serine proteases in vitro, in vivo, and in clinical settings. In PUFA-treated fibroblasts, azelaic acid decreases generation of ROS and upregulates expression of antioxidative enzymes, inhibiting cell damage; agonist activity at PPARν is thought to drive these effects. Azelaic acid also inhibits proliferation of melanocytes. This compound displays antiacne and anticancer potential as well, inhibiting the proliferation of cutaneous melanoma due to suppression of mitochondrial oxidoreductive activity and DNA synthesis. |
ALogP | 1.6 |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Estrogen receptor alpha agonist | AGONIST | ALA206 | Estrogen receptor alpha | SINGLE PROTEIN | Homo sapiens | PubMed: [1] | |
Estrogen receptor alpha modulator | MODULATOR | ALA206 | Estrogen receptor alpha | SINGLE PROTEIN | Homo sapiens | ||
Estrogen receptor alpha agonist | AGONIST | ALA206 | Estrogen receptor alpha | SINGLE PROTEIN | Homo sapiens | PubMed: [1] | |
Estrogen receptor alpha agonist | AGONIST | ALA206 | Estrogen receptor alpha | SINGLE PROTEIN | Homo sapiens | ||
Estrogen receptor alpha agonist | AGONIST | ALA206 | Estrogen receptor alpha | SINGLE PROTEIN | Homo sapiens | ||
Estrogen receptor alpha agonist | AGONIST | ALA206 | Estrogen receptor alpha | SINGLE PROTEIN | Homo sapiens | DailyMed: [1] | |
Estrogen receptor alpha modulator | MODULATOR | ALA206 | Estrogen receptor alpha | SINGLE PROTEIN | Homo sapiens | ||
Estrogen receptor alpha agonist | AGONIST | ALA206 | Estrogen receptor alpha | SINGLE PROTEIN | Homo sapiens | ISBN: [1] | |
Estrogen receptor alpha agonist | AGONIST | ALA206 | Estrogen receptor alpha | SINGLE PROTEIN | Homo sapiens | ||
Estrogen receptor alpha agonist | AGONIST | ALA206 | Estrogen receptor alpha | SINGLE PROTEIN | Homo sapiens |
IUPAC Name | nonanedioic acid |
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INCHI | InChI=1S/C9H16O4/c10-8(11)6-4-2-1-3-5-7-9(12)13/h1-7H2,(H,10,11)(H,12,13) |
InChi Key | BDJRBEYXGGNYIS-UHFFFAOYSA-N |
Canonical SMILES | C(CCCC(=O)O)CCCC(=O)O |
Isomeric SMILES | C(CCCC(=O)O)CCCC(=O)O |
WGK Germany | 1 |
RTECS | CM1980000 |
PubChem CID | 2266 |
Molecular Weight | 188.22 |
Beilstein | 1101094 |
Sensitivity | Moisture sensitive. |
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Refractive Index | 1.4303 |
Flash Point(°F) | 410 °F |
Flash Point(°C) | 210 °C |
Boil Point(°C) | 286°C |
Melt Point(°C) | 109-111°C |
Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation |
Precautionary Statements | P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P264:Wash hands [and …] thoroughly after handling. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. |
WGK Germany | 1 |
RTECS | CM1980000 |
1. Suleixin Yang, Ka Hong Wong, Peng Hua, Chengwei He, Hua Yu, Dan Shao, Zhi Shi, Meiwan Chen. (2022) ROS-responsive fluorinated polyethyleneimine vector to co-deliver shMTHFD2 and shGPX4 plasmids induces ferroptosis and apoptosis for cancer therapy. Acta Biomaterialia, 140 (492). [PMID:34879292] [10.1016/j.actbio.2021.11.042] |
2. Qi Jing, Jin Feiyang, You Yuchan, Du Yan, Liu Di, Xu Xiaoling, Wang Jun, Zhu Luwen, Chen Minjiang, Shu Gaofeng, Wu Liming, Ji Jiansong, Du Yongzhong. (2021) Synergistic effect of tumor chemo-immunotherapy induced by leukocyte-hitchhiking thermal-sensitive micelles. Nature Communications, 12 (1): (1-17). [PMID:34362890] [10.1038/s41467-021-24902-2] |
3. Jiujiang Ji, Guo Chen, Jun Zhao. (2019) Preparation and characterization of amino/thiol bifunctionalized magnetic nanoadsorbent and its application in rapid removal of Pb (II) from aqueous system. JOURNAL OF HAZARDOUS MATERIALS, 368 (255). [PMID:30684763] [10.1016/j.jhazmat.2019.01.035] |
4. Gang-Gang Yang, Hang Zhang, Dong-Yang Zhang, Qian Cao, Jing Yang, Liang-Nian Ji, Zong-Wan Mao. (2018) Cancer-specific chemotherapeutic strategy based on the vitamin K3 mediated ROS regenerative feedback and visualized drug release in vivo. BIOMATERIALS, 185 (73). [PMID:30227273] [10.1016/j.biomaterials.2018.08.065] |
5. Shuai Zhang, Na Sha, Zhe Zhao. (2017) Surface modification of α-Al2O3 with dicarboxylic acids for the preparation of UV-curable ceramic suspensions. JOURNAL OF THE EUROPEAN CERAMIC SOCIETY, 37 (1607). [PMID:] [10.1016/j.jeurceramsoc.2016.12.013] |
6. Zhijuan Sun, Xiao Wang, Fei Guo, Chunyue Jiang, Qinmin Pan. (2016) Isothermal and nonisothermal crystallization kinetics of bio-sourced nylon 69. CHINESE JOURNAL OF CHEMICAL ENGINEERING, 24 (638). [PMID:] [10.1016/j.cjche.2015.12.021] |
1. Suleixin Yang, Ka Hong Wong, Peng Hua, Chengwei He, Hua Yu, Dan Shao, Zhi Shi, Meiwan Chen. (2022) ROS-responsive fluorinated polyethyleneimine vector to co-deliver shMTHFD2 and shGPX4 plasmids induces ferroptosis and apoptosis for cancer therapy. Acta Biomaterialia, 140 (492). [PMID:34879292] [10.1016/j.actbio.2021.11.042] |
2. Qi Jing, Jin Feiyang, You Yuchan, Du Yan, Liu Di, Xu Xiaoling, Wang Jun, Zhu Luwen, Chen Minjiang, Shu Gaofeng, Wu Liming, Ji Jiansong, Du Yongzhong. (2021) Synergistic effect of tumor chemo-immunotherapy induced by leukocyte-hitchhiking thermal-sensitive micelles. Nature Communications, 12 (1): (1-17). [PMID:34362890] [10.1038/s41467-021-24902-2] |
3. Jiujiang Ji, Guo Chen, Jun Zhao. (2019) Preparation and characterization of amino/thiol bifunctionalized magnetic nanoadsorbent and its application in rapid removal of Pb (II) from aqueous system. JOURNAL OF HAZARDOUS MATERIALS, 368 (255). [PMID:30684763] [10.1016/j.jhazmat.2019.01.035] |
4. Gang-Gang Yang, Hang Zhang, Dong-Yang Zhang, Qian Cao, Jing Yang, Liang-Nian Ji, Zong-Wan Mao. (2018) Cancer-specific chemotherapeutic strategy based on the vitamin K3 mediated ROS regenerative feedback and visualized drug release in vivo. BIOMATERIALS, 185 (73). [PMID:30227273] [10.1016/j.biomaterials.2018.08.065] |
5. Shuai Zhang, Na Sha, Zhe Zhao. (2017) Surface modification of α-Al2O3 with dicarboxylic acids for the preparation of UV-curable ceramic suspensions. JOURNAL OF THE EUROPEAN CERAMIC SOCIETY, 37 (1607). [PMID:] [10.1016/j.jeurceramsoc.2016.12.013] |
6. Zhijuan Sun, Xiao Wang, Fei Guo, Chunyue Jiang, Qinmin Pan. (2016) Isothermal and nonisothermal crystallization kinetics of bio-sourced nylon 69. CHINESE JOURNAL OF CHEMICAL ENGINEERING, 24 (638). [PMID:] [10.1016/j.cjche.2015.12.021] |