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Azeliragon (TTP488) - 98%, high purity , Advanced glycosylation end product-specific receptor antagonist, CAS No.603148-36-3, Advanced glycosylation end product-specific receptor antagonist

Moligand™

≥98%

CAS#: 603148-36-3
Formula: C₃₂H₃₈ClN₃O₂
Molecular Weight: 532.12
PubChem CID: 11180124

Item Number

A413440

Grouped product items
SKU	Size	Availability	Price
A413440-5mg	5mg	In stock	$58.90
A413440-10mg	10mg	In stock	$98.90
A413440-25mg	25mg	In stock	$222.90
A413440-50mg	50mg	In stock	$315.90

View related series

advanced glycosylation end-product specific receptor Antagonist Amyloid-β Neuronal Signaling

Basic Description

Synonyms	3-(4-(2-Butyl-1-(4-(4-chlorophenoxy)phenyl)-1H-imidazol-4-yl)phenoxy)-N,N-diethylpropan-1-amine \| 3-(4-{2-Butyl-1-[4-(4-chlorophenoxy)phenyl]-1H-imidazol-4-yl}phenoxy)-N,N-diethylpropan-1-amine \| Azeliragon free base \| BCP16862 \| UNII-LPU25F15UQ \| D11147
Specifications & Purity	Moligand™, ≥98%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Advanced glycosylation end product-specific receptor antagonist
Product Description	Information Azeliragon (TTP488, PF-04494700) is an orally bioavailable small molecule that inhibits thereceptor for advanced glycation endproducts (RAGE), which is an immunoglobulin-like cell surface receptor overexpressed in brain tissues of patients with AD.

Associated Targets(Human)

AGER Tchem Advanced glycosylation end product-specific receptor (2 Activities)

Discover Target: AGER

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLC6A4 Tclin Serotonin transporter (12625 Activities)

Discover Target: SLC6A4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KCNH2 Tclin HERG (29587 Activities)

Discover Target: KCNH2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)

Discover Target: CYP1A2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)

Discover Target: CYP2C9

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)

Discover Target: CYP2C19

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)

Discover Target: CYP3A4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SH-SY5Y (11521 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HepG2 (196354 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

AGER Tchem Advanced glycosylation end product-specific receptor (291 Activities)

Discover Target: AGER

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SUM149PT (97 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	3-[4-[2-butyl-1-[4-(4-chlorophenoxy)phenyl]imidazol-4-yl]phenoxy]-N,N-diethylpropan-1-amine
INCHI	InChI=1S/C32H38ClN3O2/c1-4-7-9-32-34-31(25-10-16-28(17-11-25)37-23-8-22-35(5-2)6-3)24-36(32)27-14-20-30(21-15-27)38-29-18-12-26(33)13-19-29/h10-21,24H,4-9,22-23H2,1-3H3
InChi Key	KJNNWYBAOPXVJY-UHFFFAOYSA-N
Canonical SMILES	CCCCC1=NC(=CN1C2=CC=C(C=C2)OC3=CC=C(C=C3)Cl)C4=CC=C(C=C4)OCCCN(CC)CC
Isomeric SMILES	CCCCC1=NC(=CN1C2=CC=C(C=C2)OC3=CC=C(C=C3)Cl)C4=CC=C(C=C4)OCCCN(CC)CC
PubChem CID	11180124
Molecular Weight	532.12

PubChem CID

11180124

CAS Registry No.

603148-36-3

Certificates

Certificate of Analysis(COA)

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4 results found

Lot Number	Certificate Type	Date	Item
H2206412	Certificate of Analysis	Jun 13, 2022	A413440
H2206419	Certificate of Analysis	Jun 13, 2022	A413440
H2206434	Certificate of Analysis	Jun 13, 2022	A413440
H2206438	Certificate of Analysis	Jun 13, 2022	A413440

References

1. Deane R, Du Yan S, Submamaryan RK, LaRue B, Jovanovic S, Hogg E, Welch D, Manness L, Lin C, Yu J et al.. (2003) RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain.. Nat Med, 9 (7): (907-13). [PMID:12808450] [10.1021/op500134e]
2. Burstein AH, Grimes I, Galasko DR, Aisen PS, Sabbagh M, Mjalli AM. (2014) Effect of TTP488 in patients with mild to moderate Alzheimer's disease.. BMC Neurol, 14 (13): (12). [PMID:24423155] [10.1021/op500134e]
3. Saito S, Ihara M. (2014) New therapeutic approaches for Alzheimer's disease and cerebral amyloid angiopathy.. Front Aging Neurosci, 6 (13): (290). [PMID:25368578] [10.1021/op500134e]

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Azeliragon (TTP488) - 98%, high purity , Advanced glycosylation end product-specific receptor antagonist, CAS No.603148-36-3, Advanced glycosylation end product-specific receptor antagonist

Basic Description

Product Properties

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

Related Documents

References

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Dilution Calculator

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