Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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A134451-25mg | 25mg | In stock | $391.90 |
Synonyms | Aritromicina [Spanish] | AZITHROMYCIN DIHYDRATE | Macrozit | Sumamed | Zentavion | NSC643732 | SR-01000080110-1 | Toraseptol | Azithromycin (Zithromax) | CP 62993 | Spectrum_000307 | Azithrocin | KBioGR_000731 | Tobil | Z-Pak | 9-Deoxo-9a-aza-9a-methyl-9a |
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Specifications & Purity | Moligand™, analytical standard |
Shipped In | Normal |
Grade | analytical standard, Moligand™ |
Action Type | AGONIST, INHIBITOR |
Mechanism of action | Bacterial 70S ribosome inhibitor |
ALogP | 4 |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-3,4,10-trihydroxy-13-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,6,8,10,12,14-heptamethyl-1-oxa-6-azacyclopentadecan-15-one |
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INCHI | InChI=1S/C38H72N2O12/c1-15-27-38(10,46)31(42)24(6)40(13)19-20(2)17-36(8,45)33(52-35-29(41)26(39(11)12)16-21(3)48-35)22(4)30(23(5)34(44)50-27)51-28-18-37(9,47-14)32(43)25(7)49-28/h20-33,35,41-43,45-46H,15-19H2,1-14H3/t20-,21-,22+,23-,24-,25+,26+,27-,28+,29-,30+,31-,32+,33-,35+,36-,37-,38-/m1/s1 |
InChi Key | MQTOSJVFKKJCRP-BICOPXKESA-N |
Canonical SMILES | CCC1C(C(C(N(CC(CC(C(C(C(C(C(=O)O1)C)OC2CC(C(C(O2)C)O)(C)OC)C)OC3C(C(CC(O3)C)N(C)C)O)(C)O)C)C)C)O)(C)O |
Isomeric SMILES | CC[C@@H]1[C@@]([C@@H]([C@H](N(C[C@@H](C[C@@]([C@@H]([C@H]([C@@H]([C@H](C(=O)O1)C)O[C@H]2C[C@@]([C@H]([C@@H](O2)C)O)(C)OC)C)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)O)(C)O)C)C)C)O)(C)O |
WGK Germany | 2 |
RTECS | RN6960000 |
PubChem CID | 447043 |
Molecular Weight | 748.98 |
DrugBank Ligand | DB00207 |
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CAS Registry No. | 83905-01-5 |
Wikipedia | Azithromycin |
PubChem CID | 447043 |
ChEMBL Ligand | CHEMBL529 |
RCSB PDB Ligand | ZIT |
DrugCentral Ligand | 276 |
Antibiotic DB | 1342 |
GPCRdb Ligand | azithromycin |
Enter Lot Number to search for COA:
Pictogram(s) | GHS08, GHS09, GHS07 |
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Signal | Danger |
Hazard Statements | H317:May cause an allergic skin reaction H334:May cause allergy or asthma symptoms or breathing difficulties if inhaled H400:Very toxic to aquatic life H410:Very toxic to aquatic life with long lasting effects H372:Causes damage to organs through prolonged or repeated exposure |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P284:[In case of inadequate ventilation] Wear respiratory protection. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P391:Collect spillage. P319:Get medical help if you feel unwell. P342+P316:If experiencing respiratory symptoms: Get emergence medical help immediately. |
WGK Germany | 2 |
RTECS | RN6960000 |
1. Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu. (2024) Microenvironment responsive charge-switchable nanoparticles act on biofilm eradication and virulence inhibition for chronic lung infection treatment. JOURNAL OF CONTROLLED RELEASE, 365 (4): (219). [PMID:37992874] [10.1016/j.jconrel.2023.11.032] |
2. Tong Shao, Xiaoshuang Wang, Rentian Guan, Suyuan Zeng, Rui Li, Min Hong, Qiaoli Yue. (2023) Carbonized polymer dots for the sensitive and selective analysis of chlortetracycline based on the aggregation induced emission. NEW JOURNAL OF CHEMISTRY, 47 (37): (17293-17302). [PMID:] [10.1039/D3NJ02474A] |
3. Jingmin Cui, Yan Sun, Linqing Wang, Wenqiang Tan, Zhanyong Guo. (2023) Preparation of chitosan derivatives containing aromatic five-membered heterocycles for efficient antimicrobial and antioxidant activities. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 247 (125850). [PMID:37460067] [10.1016/j.ijbiomac.2023.125850] |
4. Wenjuan Dong, Lu Wang, Rongrong Zhang, Chaochao Wen, Ren Su, Xiaojuan Gong, Wenting Liang. (2023) High luminescent N,S,P co-doped carbon dots for the fluorescence sensing of extreme acidity and folic acid. DALTON TRANSACTIONS, 52 (19): (6551-6558). [PMID:37185994] [10.1039/D3DT00560G] |
5. Xiu-Yan Li, Yu-Ting Luo, Yan-Hong Wang, Zhi-Xin Yang, Yu-Zhou Shang, Qing-Xia Guan. (2023) Anti-inflammatory effect and antihepatoma mechanism of carrimycin. WORLD JOURNAL OF GASTROENTEROLOGY, 29 (14): ( 2134–2152). [PMID:37122599] [10.3748/wjg.v29.i14.2134] |
6. Jingmin Cui, Yan Sun, Linqing Wang, Qin Miao, Wenqiang Tan, Zhanyong Guo. (2022) Preparation of l-Arginine Schiff Bases Modified Chitosan Derivatives and Their Antimicrobial and Antioxidant Properties. Marine Drugs, 20 (11): (688). [PMID:36355011] [10.3390/md20110688] |
7. Yuhan Yang, Yangyi Chen, Dianpeng Li, Shiyuan Lin, Hui Chen, Wei Wu, Wei Zhang. (2023) Linolenic acid conjugated chitosan micelles for improving the oral absorption of doxorubicin via fatty acid transporter. CARBOHYDRATE POLYMERS, 300 (120233). [PMID:36372473] [10.1016/j.carbpol.2022.120233] |
8. Kairong Yang, Pei Jia, Jinjie Hou, Shuang Zhao, Li Wang. (2022) An ingenious turn-on ratiometric fluorescence sensor for sensitive and visual detection of tetracyclines. FOOD CHEMISTRY, 396 (133693). [PMID:35868283] [10.1016/j.foodchem.2022.133693] |
9. Lishan Zhang, Zujie Yao, Huamei Tang, Qingli Song, Huanhuan Song, Jindong Yao, Zhen Li, Xiaofang Xie, Yuexu Lin, Xiangmin Lin. (2022) The Lysine Acetylation Modification in the Porin Aha1 of Aeromonas hydrophila Regulates the Uptake of Multidrug Antibiotics. MOLECULAR & CELLULAR PROTEOMICS, 21 (9): [PMID:35605723] [10.1016/j.mcpro.2022.100248] |
10. Yi Zhang, Zhaoju Wu, Haizhu Shi, Yang Xie, Ming-Yu Wu, Chungu Zhang, Shun Feng. (2022) Copper mediated molecularly imprinted polymers for fast recognizing tylosin. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 213 (114674). [PMID:35219066] [10.1016/j.jpba.2022.114674] |
11. Jingmin Cui, Xia Ji, Yingqi Mi, Qin Miao, Fang Dong, Wenqiang Tan, Zhanyong Guo. (2022) Antimicrobial and Antioxidant Activities of N-2-Hydroxypropyltrimethyl Ammonium Chitosan Derivatives Bearing Amino Acid Schiff Bases. Marine Drugs, 20 (2): (86). [PMID:35200616] [10.3390/md20020086] |
12. Sumei Yu, Yingnan Wang, Fan Shen, Hua Fang, Yunlong Yu. (2022) Copper-based fungicide copper hydroxide accelerates the evolution of antibiotic resistance via gene mutations in Escherichia coli. SCIENCE OF THE TOTAL ENVIRONMENT, 815 (152885). [PMID:34998765] [10.1016/j.scitotenv.2021.152885] |
13. Li Zhang, Huaizhong Xing, Wei Liu, Zihan Wang, Yumin Hao, Huiping Wang, Wenjuan Dong, Yang Liu, Shaomin Shuang, Chuan Dong, Xiaojuan Gong. (2021) 11-Mercaptoundecanoic Acid-Functionalized Carbon Dots As a Ratiometric Optical Probe for Doxorubicin Detection. ACS Applied Nano Materials, 4 (12): (13734–13746). [PMID:] [10.1021/acsanm.1c03141] |
14. Xin Wang, Longwen Li, Hong Jiang, Hui Zhangsun, Qinzhi Wang, Xinyu Sun, Li Wang. (2022) Highly selective and sensitive fluorescence detection of tetracyclines based on novel tungsten oxide quantum dots. FOOD CHEMISTRY, 374 (131774). [PMID:34896945] [10.1016/j.foodchem.2021.131774] |
15. Zongbao Sun, Yunlong Gao, Zeng Niu, Haodong Pan, Xuechao Xu, Wen Zhang, Xiaobo Zou. (2021) Programmable-Printing Paper-Based Device with a MoS2 NP and Gmp/Eu-Cit Fluorescence Couple for Ratiometric Tetracycline Analysis in Various Natural Samples. ACS Sensors, 6 (11): (4038–4047). [PMID:34672196] [10.1021/acssensors.1c01448] |
16. Yu-Xi Gao, Xing Li, Jun-Ru Zhao, Zhong-Xing Zhang, Xiao-Yan Fan. (2021) Response of microbial communities based on full-scale classification and antibiotic resistance genes to azithromycin and copper combined pollution in activated sludge nitrification laboratory mesocosms at low temperature. BIORESOURCE TECHNOLOGY, 341 (125859). [PMID:34523571] [10.1016/j.biortech.2021.125859] |
17. Yu Wang, Jin-Yi Yang, Ying He, Lu Li, Jian-Xin Huang, Yuan-Xin Tian, Hong Wang, Zhen-Lin Xu, Yu-Dong Shen. (2021) Development of Time-Resolved Fluorescence Immunochromatographic Assays for Simultaneously Detecting Tylosin and Tilmicosin in Milk in Group-Screening Manner. Foods, 10 (8): (1838). [PMID:34441616] [10.3390/foods10081838] |
18. Tahereh Sadeghian Renani, Seyyed Mehdi Khoshfetrat, Jalal Arjomandi, Hu Shi, Sadegh Khazalpour. (2021) Fabrication and design of new redox active azure A/3D graphene aerogel and conductive trypan blue–nickel MOF nanosheet array electrodes for an asymmetric supercapattery. Journal of Materials Chemistry A, 9 (21): (12853-12869). [PMID:] [10.1039/D1TA02850B] |
19. Yanan Yan, Lin Li, Huilin Zhang, Fangfang Du, Yating Meng, Shaomin Shuang, Ruibing Wang, Shengmei Song, Chuan Dong. (2021) Carbon dots for ratiometric fluorescence detection of morin. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 256 (119751). [PMID:33819765] [10.1016/j.saa.2021.119751] |
20. Yijian Zhao, Qinzhi Wang, Haihua Wang, Hui Zhangsun, Xinyu Sun, Tong Bu, Yingnan Liu, Wenze Wang, Zhihao Xu, Li Wang. (2021) Europium-based metal-organic framework containing characteristic metal chains: A novel turn-on fluorescence sensor for simultaneous high-performance detection and removal of tetracycline. SENSORS AND ACTUATORS B-CHEMICAL, 334 (129610). [PMID:] [10.1016/j.snb.2021.129610] |
21. Xueqing Guo, Yang Liu, Wenjuan Dong, Qin Hu, Yong Li, Shaomin Shuang, Chuan Dong, Lishuai Cai, Xiaojuan Gong. (2021) Azithromycin detection in cells and tablets by N,S co-doped carbon quantum dots. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 252 (119506). [PMID:33561684] [10.1016/j.saa.2021.119506] |
22. Ya Chen, Zhiping Wang, Lili Liu, Hanbin Zhao, Pin Wu. (2021) Stress-responses of microbial population and activity in activated sludge under long-term ciprofloxacin exposure. JOURNAL OF ENVIRONMENTAL MANAGEMENT, 281 (111896). [PMID:33360923] [10.1016/j.jenvman.2020.111896] |
23. Yingnan Liu, Yaqing Xiao, Min Yu, Yuanyuan Cao, Yalan Zhang, Taotao Zhe, Hui Zhang, Li Wang. (2020) Antimonene Quantum Dots as an Emerging Fluorescent Nanoprobe for the pH-Mediated Dual-Channel Detection of Tetracyclines. Small, 16 (42): (2003429). [PMID:32996281] [10.1002/smll.202003429] |
24. Tianlin Wang, Qingsong Mei, Zhanhui Tao, Haotian Wu, Minyang Zhao, Shuo Wang, Yaqing Liu. (2020) A smartphone-integrated ratiometric fluorescence sensing platform for visual and quantitative point-of-care testing of tetracycline. BIOSENSORS & BIOELECTRONICS, 148 (111791). [PMID:31677526] [10.1016/j.bios.2019.111791] |
25. Wang Y, Pan L, Li L, Cao R, Zheng Q, Xu Z, Wu CJ, Zhu H.. (2022) Glycosylation increases the anti-QS as well as anti-biofilm and anti-adhesion ability of the cyclo (L-Trp-L-Ser) against Pseudomonas aeruginosa.. Eur J Med Chem, 238 (114457-114457). [PMID:35605361] [10.1016/j.ejmech.2022.114457] |
1. Dahl EL, Rosenthal PJ. (2007) Multiple antibiotics exert delayed effects against the Plasmodium falciparum apicoplast.. Antimicrob Agents Chemother, 51 (10): (3485-90). [PMID:17698630] [10.1021/op500134e] |
2. van Eijk AM, Terlouw DJ. (2011) Azithromycin for treating uncomplicated malaria.. Cochrane Database Syst Rev, 71 (2): (CD006688). [PMID:21328286] [10.1021/op500134e] |
3. Zhang Y, Ge L, Song G, Zhang R, Li S, Shi H, Zhang H, Li Y, Pan J, Wang L et al.. (2022) Azithromycin alleviates the severity of rheumatoid arthritis by targeting the unfolded protein response component of glucose-regulated protein 78 (GRP78).. Br J Pharmacol, 179 (6): (1201-1219). [PMID:34664264] [10.1021/op500134e] |
4. Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu. (2024) Microenvironment responsive charge-switchable nanoparticles act on biofilm eradication and virulence inhibition for chronic lung infection treatment. JOURNAL OF CONTROLLED RELEASE, 365 (4): (219). [PMID:37992874] [10.1016/j.jconrel.2023.11.032] |
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