Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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E110147-100mg | 100mg | In stock | $171.90 | |
E110147-250mg | 250mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $342.90 | |
E110147-500mg | 500mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $604.90 | |
E110147-1g | 1g | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,085.90 | |
E110147-5g | 5g | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $4,806.90 |
Synonyms | 3,17-Epidihydroxyestratriene | Estraderm TTS 50 | Dihydromenformon | Compudose 365 | Dihydroxyesterin | Estrace | Primofol | B-Estradiol | Estrogens, esterified | Oestergon | Ovastevol | Alora | Corpagen | Syndiol | 17b-Oestradiol | Gynodiol | Dihydrofoll |
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Specifications & Purity | Moligand™, analytical standard, ≥99.5% |
Storage Temp | Room temperature,Desiccated |
Shipped In | Normal |
Grade | analytical standard, Moligand™ |
Action Type | ACTIVATOR, AGONIST, INHIBITOR |
Mechanism of action | Agonist of Estrogen receptor-α;Agonist of Estrogen receptor-β;Agonist of GPER;Activator of K Ca1.1;Agonist of Pregnane X receptor;Inhibitor of Proton-coupled Amino acid Transporter 1 |
ALogP | 4 |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | (8R,9S,13S,14S,17S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol |
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INCHI | InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1 |
InChi Key | VOXZDWNPVJITMN-ZBRFXRBCSA-N |
Canonical SMILES | CC12CCC3C(C1CCC2O)CCC4=C3C=CC(=C4)O |
Isomeric SMILES | C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)CCC4=C3C=CC(=C4)O |
WGK Germany | 3 |
RTECS | KG2975000 |
Alternate CAS | 50-28-2,17916-67-5 |
PubChem CID | 5757 |
NSC Number | 9895 |
MeSH Entry Terms | 17 beta Estradiol;17 beta Oestradiol;17 beta-Estradiol;17 beta-Oestradiol;Aerodiol;Delestrogen;Estrace;Estraderm TTS;Estradiol;Estradiol 17 alpha;Estradiol 17 beta;Estradiol 17beta;Estradiol Anhydrous;Estradiol Hemihydrate;Estradiol Hemihydrate, (17 alpha |
Molecular Weight | 272.38 |
Beilstein | 1914275 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
L2010237 | Certificate of Analysis | Sep 20, 2022 | E110147 |
H2219252 | Certificate of Analysis | Aug 03, 2022 | E110147 |
H2219253 | Certificate of Analysis | Aug 03, 2022 | E110147 |
H2031022 | Certificate of Analysis | Jun 24, 2022 | E110147 |
Specific Rotation[α] | 80.4 ° (C=1, Dioxane) |
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Melt Point(°C) | 175-180°C |
Pictogram(s) | GHS08, GHS09 |
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Signal | Danger |
Hazard Statements | H351:Suspected of causing cancer H400:Very toxic to aquatic life H410:Very toxic to aquatic life with long lasting effects H372:Causes damage to organs through prolonged or repeated exposure H360:May damage fertility or the unborn child H350:May cause cancer H360FD:May damage fertility; May damage the unborn child H362:May cause harm to breast-fed children |
Precautionary Statements | P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P270:Do not eat, drink or smoke when using this product. P391:Collect spillage. P263:Avoid contact during pregnancy/while nursing. P203:Obtain, read and follow all safety instructions before use. P318:if exposed or concerned, get medical advice. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |
RTECS | KG2975000 |
Merck Index | 3703 |
1. Longjie Liu, Zeyang Lu, Wanling Cai, Gary Owens, Zuliang Chen. (2024) Green rGO/FeNPs nanocomposites activated peroxydisulfate for the removal of mixed 17β-estradiol and estriol. ENVIRONMENTAL RESEARCH, 245 (118057). [PMID:38154565] [10.1016/j.envres.2023.118057] |
2. Junxian Zhu, Yongchang Wang, Luo Lei, Chen Chen, Liqin Ji, Jiansong Li, Congcong Wu, Wenjun Yu, Laifu Luo, Weiqin Chen, Pan Liu, Xiaoyou Hong, Xiaoli Liu, Haigang Chen, Chengqing Wei, Xinping Zhu, Wei Li. (2024) Comparative genomic survey and functional analysis of DKKL1 during spermatogenesis in the Chinese soft-shelled turtle (Pelodiscus sinensis). INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 254 (17): (127696). [PMID:37913874] [10.1016/j.ijbiomac.2023.127696] |
3. Min Liu, Yong-Jie Mi, Juan Dai. (2023) Aquaporin 7 is upregulated through the PI3K-Akt pathway and modulates decidualisation of endometrial stromal cells. REPRODUCTION FERTILITY AND DEVELOPMENT, 35 (14): (669-675). [PMID:37879294] [10.1071/RD23054] |
4. Yue Bao, Yixin Zhai, Siyuan Di, Hailan Qin, Shukui Zhu. (2023) Room-temperature synthesis of magnetic thiophene-based covalent organic frameworks for derivatization-assisted GC–MS analysis of estrogens in environmental water. MICROCHEMICAL JOURNAL, 195 (7): (109524). [PMID:16281057] [10.1016/j.microc.2023.109524] |
5. Yajun Zhang, Licong Jia, Wei Wang, Meng Jiang, Hongying Zhang, LingMei Niu. (2023) A novel fluorescent sensor based on aptamer recognition and DNA walker amplification strategy and its determination of 17β-estradiol. Arabian Journal of Chemistry, 16 (105340). [PMID:24006492] [10.1016/j.arabjc.2023.105340] |
6. Min Jia, Fupei Xu, Fei Zhai, Xiaoying Yu, Meixia Du. (2023) An all-in-one portable colorimetric detection platform for sensitive detection of bisphenol A based on target-mediated CeO2@ZIF-8/Apt biocomposites. JOURNAL OF COLLOID AND INTERFACE SCIENCE, (10): [PMID:37845127] [10.1016/j.jcis.2023.10.055] |
7. Tianrun Qian, Jia Bao, Xuepeng Liu, Gerile Oudeng, Weiwei Ye. (2023) A “turn-on” fluorescence resonance energy transfer aptasensor based on carbon dots and gold nanoparticles for 17β-estradiol detection in sea salt. RSC Advances, 13 (40): (27772-27781). [PMID:37731834] [10.1039/D3RA05410A] |
8. Rui Zhao, Cheng Cheng, Xiurong Wu, Xueyan Bai, Fenghuan Wang. (2023) Post-synthetic modification of NH2-MIL-101(Al)@SiO2 with different non-polar ligands for improving HPLC separation performance of estrogens. JOURNAL OF SOLID STATE CHEMISTRY, 328 (124289). [PMID:19875381] [10.1016/j.jssc.2023.124289] |
9. Yachao Hao, Wei Zhou, Xin Wang, Youping Liu, Xin Di. (2023) Carboxyl-based deep eutectic solvent modified magnetic graphene oxide as a novel adsorbent for fast enrichment and extraction of estrogens in milk prior to HPLC-UV analysis. MICROCHEMICAL JOURNAL, 193 (109050). [PMID:] [10.1016/j.microc.2023.109050] |
10. Lu Yang, Heng Li, Xiaoying Jin, Zuliang Chen. (2023) The origins of potentially superior properties and multifunctionalities of carbon-nano zero-valent iron in the carbonization pyrolysis process. JOURNAL OF ENVIRONMENTAL MANAGEMENT, 344 (118457). [PMID:37352626] [10.1016/j.jenvman.2023.118457] |
11. Banghao Du, Gongduan Fan, Shangwu Yang, Jing Luo, Jiaxin Wu, Kai-Qin Xu. (2023) Mechanistic insight into humic acid-enhanced sonophotocatalytic removal of 17β-estradiol: Formation and contribution of reactive intermediates. ENVIRONMENTAL RESEARCH, 231 (116249). [PMID:37247656] [10.1016/j.envres.2023.116249] |
12. Lianxia Guo, Haobin Cen, Jiaxian Weng, Yiting He, Xiaocao Guo, Di He, Kaisheng Liu, Shuyi Duan, Jing Yang, Xiaojian Zhang, Zifei Qin, Yong Wan, Zhiyong Chen, Baojian Wu. (2023) PER2 integrates circadian disruption and pituitary tumorigenesis. Theranostics, 13 (8): ( 2657–2672). [PMID:37215573] [10.7150/thno.82995] |
13. Qing Liu, Chao Yan, Yan Wang. (2023) Submicron Nonporous Silica Particles for Enhanced Separation Performance in pCEC. MOLECULES, 28 (8): (3542). [PMID:37110774] [10.3390/molecules28083542] |
14. Di Li, Ting Sun, Yongqing Tong, Juan Le, Qian Yao, Jun Tao, Hang Liu, Woer Jiao, Yufeng Mei, Jingru Chen, Zhongchun Liu, Gaohua Wang, Yan Li. (2023) Gut-microbiome-expressed 3β-hydroxysteroid dehydrogenase degrades estradiol and is linked to depression in premenopausal females. Cell Metabolism, 35 (685-694.e5). [PMID:36933555] [10.1016/j.cmet.2023.02.017] |
15. Jiameng Liu, Mengfei Wang, Chuanpan Guo, Zheng Tao, Minghua Wang, Linghao He, Baozhong Liu, Zhihong Zhang. (2023) Defective porphyrin-based metal-organic framework nanosheets derived from V2CTx MXene as a robust bioplatform for impedimetric aptasensing 17β-estradiol. FOOD CHEMISTRY, 416 (135839). [PMID:36893636] [10.1016/j.foodchem.2023.135839] |
16. Haojie Zeng, Feiyun Sun, Jianjun Zhang, Ying Wang, Songwen Yang, Dingyu Xing. (2023) Gradient crosslinking optimization for the selective layer to prepare polyvinyl alcohol (PVA) nanofiltration (NF) membrane: The enhanced filtration performance and potential rejection for EDCs. JOURNAL OF MEMBRANE SCIENCE, 675 (121548). [PMID:] [10.1016/j.memsci.2023.121548] |
17. Dai Yin, Jiang Wei, Zheng Yani, He Pei, Zhu Ruizhi, Fei Jianwen, Xu Wei, Liu Chunbo, Hong Junli. (2022) Recyclable molecularly imprinted polymers based on Fe3O4@SiO2 and PAMAM dendrimers for the determination of myosmine in cigarettes. MICROCHIMICA ACTA, 189 (12): (1-10). [PMID:36422716] [10.1007/s00604-022-05529-6] |
18. Liling Wang, Huan Wang, Jing Luo, Ting Xie, Gil Mor, Aihua Liao. (2022) Decorin promotes decidual M1-like macrophage polarization via mitochondrial dysfunction resulting in recurrent pregnancy loss. Theranostics, 12 (17): ( 7216–7236). [PMID:36438479] [10.7150/thno.78467] |
19. Yashi Qing, Yanxiang Li, Zhiwei Guo, Yujie Yang, Wangliang Li. (2022) Photocatalytic Bi2WO6/pg-C3N4-embedded in polyamide microfiltration membrane with enhanced performance in synergistic adsorption-photocatalysis of 17β-estradiol from water. Journal of Environmental Chemical Engineering, 10 (108648). [PMID:] [10.1016/j.jece.2022.108648] |
20. Liangliang He, Chanjuan Chen, Shuyi Duan, Yang Li, Chuan Li, Xinsheng Yao, Frank J. Gonzalez, Zifei Qin, Zhihong Yao. (2023) Inhibition of estrogen sulfation by Xian-Ling-Gu-Bao capsule. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 225 (106182). [PMID:36152789] [10.1016/j.jsbmb.2022.106182] |
21. Shuo Wang, Pengfei Li, Yehong Han, Haiyan Liu, Hongyuan Yan. (2022) Selective enrichment and determination of polychlorinated biphenyls in milk by solid-phase microextraction using molecularly imprinted phenolic resin fiber coating. ANALYTICA CHIMICA ACTA, 1227 (340328). [PMID:36089327] [10.1016/j.aca.2022.340328] |
22. Yanqun Yang, Yipeng Huang, Zhuqiang Wu, Rui Shi, Zhengyi Chen, Guihua Ruan. (2022) Porous capillary monolithic column coupled with ultrahigh performance liquid chromatography-tandem mass spectrometry for fast and effective separation and determination of estrogens. ANALYTICA CHIMICA ACTA, 1227 (340270). [PMID:36089309] [10.1016/j.aca.2022.340270] |
23. Shuo Qi, Xiaoze Dong, Yuhan Sun, Yin Zhang, Nuo Duan, Zhouping Wang. (2022) Split aptamer remodeling-initiated target-self-service 3D-DNA walker for ultrasensitive detection of 17β-estradiol. JOURNAL OF HAZARDOUS MATERIALS, 439 (129590). [PMID:35872451] [10.1016/j.jhazmat.2022.129590] |
24. M. S. Bacchu, M. R. Ali, M. N. Hasan, M. R. A. Mamun, M. I. Hossain, M. Z. H. Khan. (2022) Graphitic carbon nitride and APTES modified advanced electrochemical biosensor for detection of 17β-estradiol in spiked food samples. RSC Advances, 12 (26): (16581-16588). [PMID:35754912] [10.1039/D2RA02315F] |
25. Hui Lyu, Xinze Wu, Yinpeng Yang, Huaixia Chen, Xueping Dang, Xiaolan Liu. (2022) Preparation, characterization and application of double yolk–shell structure magnetic molecularly imprinted polymers for extraction of 17β-estradiol. NEW JOURNAL OF CHEMISTRY, 46 (24): (11927-11933). [PMID:] [10.1039/D2NJ00237J] |
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