Determine the necessary mass, volume, or concentration for preparing a solution.
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
Basic Description
| Synonyms | 2-NAPHTHYLAMINE | 2-Aminonaphthalene | 91-59-8 | naphthalen-2-amine | 2-Naphthalenamine | beta-Naphthylamine | 6-Naphthylamine | beta-Naftilamina | 2-Naphthalamine | 2-Naphthylamin | 2-Naphtylamine | Fast Scarlet Base B | Naphthalen-2-ylamine | 2-Aminonaftalen | 2-Naftylamine | 2-Naft |
|---|---|
| Specifications & Purity | analytical standard |
| Shipped In | Normal |
| Grade | analytical standard |
| Product Description | 2-Naphthylamine is an aromatic amine used to make azo dyes. A common reason that it is used less for this purpose is that the substance is a carcinogen. Studies indicate that 2-Naphthylamine decreases the enzymatic functions of monoamine oxidase A and B. It is known that the main source of this compound is obtained from cigarette smoke. In addition, metabolites of 2-Naphthylamine such as N-hydroxy-2-Naphthylamine damages DNA by forming specific carcinogen-base adducts. These studies suggest that specific 2-Naphthylamine can cause problems for cells by binding to glycogen. |
Associated Targets(Human)
CYP3A4 Tclin Cytochrome P450 3A4 (0 Activities)
NR3C1 Tclin Glucocorticoid receptor (0 Activities)
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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RORC Tchem Nuclear receptor ROR-gamma (0 Activities)
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SULT4A1 Tbio Sulfotransferase 4A1 (0 Activities)
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
HSD17B10 Tchem 3-hydroxyacyl-CoA dehydrogenase type-2 (0 Activities)
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
TXNRD1 Tclin Thioredoxin reductase 1, cytoplasmic (0 Activities)
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
UGT2B15 Tbio UDP-glucuronosyltransferase 2B15 (0 Activities)
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
UGT1A1 Tchem UDP-glucuronosyltransferase 1-1 (0 Activities)
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
UGT1A4 Tbio UDP-glucuronosyltransferase 1-4 (0 Activities)
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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UGT1A9 Tbio UDP-glucuronosyltransferase 1-9 (0 Activities)
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
TEC Tchem Tyrosine-protein kinase Tec (0 Activities)
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
RGS4 Tchem Regulator of G-protein signaling 4 (0 Activities)
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
NR1I2 Tchem Nuclear receptor subfamily 1 group I member 2 (0 Activities)
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
CLPP Tchem ATP-dependent Clp protease proteolytic subunit, mitochondrial (0 Activities)
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
AHR Tclin Aryl hydrocarbon receptor (0 Activities)
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
AR Tclin Androgen receptor (0 Activities)
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
GNAS Tbio Protein ALEX (0 Activities)
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
ALDH1A1 Tchem Retinal dehydrogenase 1 (0 Activities)
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
UGT1A3 Tbio UDP-glucuronosyltransferase 1-3 (0 Activities)
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
UGT1A6 Tbio UDP-glucuronosyltransferase 1-6 (0 Activities)
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
NFE2L2 Tchem Nuclear factor erythroid 2-related factor 2 (0 Activities)
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
NCF1 Tbio Neutrophil cytosol factor 1 (0 Activities)
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
NR3C1 Tclin Glucocorticoid receptor (14987 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
AR Tclin Androgen Receptor (11781 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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AHR Tclin Aryl hydrocarbon receptor (1071 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
UGT1A4 Tbio UDP-glucuronosyltransferase 1A4 (288 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
HSD17B10 Tchem Endoplasmic reticulum-associated amyloid beta-peptide-binding protein (20669 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
GNAS Tbio Guanine nucleotide-binding protein G(s), subunit alpha (103405 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
UGT2B15 Tbio UDP-glucuronosyltransferase 2B15 (172 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
UGT1A1 Tchem UDP-glucuronosyltransferase 1-1 (448 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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NCF1 Tbio Neutrophil cytosol factor 1 (245 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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SULT4A1 Tbio Sulfotransferase 4A1 (6 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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UGT1A6 Tbio UDP-glucuronosyltransferase 1-6 (221 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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UGT1A9 Tbio UDP-glucuronosyltransferase 1-9 (343 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
RGS4 Tchem Regulator of G-protein signaling 4 (13867 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Associated Targets(non-human)
Tec Tyrosine-protein kinase TEC (25 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Rattus norvegicus (775804 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Rorc Nuclear receptor ROR-gamma (89407 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Nr1i2 Nuclear receptor subfamily 1 group I member 2 (14 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
clpP ATP-dependent Clp protease proteolytic subunit (245 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Mechanisms of Action
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
Names and Identifiers
| IUPAC Name | naphthalen-2-amine |
|---|---|
| INCHI | InChI=1S/C10H9N/c11-10-6-5-8-3-1-2-4-9(8)7-10/h1-7H,11H2 |
| InChi Key | JBIJLHTVPXGSAM-UHFFFAOYSA-N |
| Canonical SMILES | C1=CC=C2C=C(C=CC2=C1)N |
| Isomeric SMILES | C1=CC=C2C=C(C=CC2=C1)N |
| WGK Germany | 3 |
| RTECS | QM2100000 |
| PubChem CID | 7057 |
| UN Number | 1650(solid)3411(solution) |
| Packing Group | II |
| Molecular Weight | 143.19 |
| Beilstein | 3939429 |
Certificates
Certificate of Analysis(COA)
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 B1625093 | Certificate of Analysis | Jul 12, 2023 | N113461 |
Chemical and Physical Properties
| Solubility | Soluble in Ethyl Acetate and Methanol |
|---|---|
| Boil Point(°C) | 306°C |
| Melt Point(°C) | 111-113°C |
Safety and Hazards(GHS)
| Pictogram(s) | GHS08, GHS09, GHS07 |
|---|---|
| Signal | Danger |
| Hazard Statements | H411:Toxic to aquatic life with long lasting effects H302:Harmful if swallowed H350:May cause cancer |
| Precautionary Statements | P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P391:Collect spillage. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. |
| WGK Germany | 3 |
| RTECS | QM2100000 |
| Class | 6.1 |
Related Documents
Citations of This Product
| 1. Qidong Yu, Wenmin Zhang, Hui Chen, Jingyi Wang, Zhiyong Wang, Qingqing Ding, Lan Zhang. (2023) Synthesis of stable and efficient amide-based covalent organic frameworks fiber coatings for the improved solid-phase microextraction of polar aromatic amines. ANALYTICA CHIMICA ACTA, 1284 (20): (342002). [PMID:37996159] [10.1016/j.aca.2023.342002] |
| 2. Lingfeng Xu, Ying Zou, Mei Zeng, Siqi Duan, Kui Wu, Runlin Han, Limin Liu. (2022) Noninvasive Viscosity Detection in Beverages with an Aggregation-Induced Emission-Based Molecular Rotor. ACS Food Science & Technology, 2 (1): (49–56). [PMID:] [10.1021/acsfoodscitech.1c00302] |
| 3. Qingqing Li, Wenmin Zhang, Yuheng Guo, Hui Chen, Qingqing Ding, Lan Zhang. (2021) Oxygenated carbon nanotubes cages coated solid-phase microextraction fiber for selective extraction of migrated aromatic amines from food contact materials. JOURNAL OF CHROMATOGRAPHY A, 1646 (462031). [PMID:33857834] [10.1016/j.chroma.2021.462031] |
| 4. Wang Jun, Wang Yuru, Song Lei, Wang Hua, Wang Jiaming, Li Cuiqin. (2017) Synthesis and antioxidant capacity of a C12-naphthylamine antioxidant in polyethylene. POLYMER BULLETIN, 74 (9): (3689-3705). [PMID:] [10.1007/s00289-017-1917-2] |
| 5. Xiang Han, Dong-En Wang, Sheng Chen, Longlong Zhang, Yadan Guo, Jinyi Wang. (2015) A new rhodamine-based chemosensor for turn-on fluorescent detection of Fe3+. Analytical Methods, 7 (10): (4231-4236). [PMID:] [10.1039/C5AY00568J] |
| 6. Jing Li,Li Xu,Zhi-Guo Shi. (2018-12-12) Waxberry-like hierarchically porous ethyl-bridged hybrid silica microsphere: A substrate for enzyme catalysis and high-performance liquid chromatography.. Journal of chromatography. A, 1587 (79-87). [PMID:30527847] |
References
| 1. Qidong Yu, Wenmin Zhang, Hui Chen, Jingyi Wang, Zhiyong Wang, Qingqing Ding, Lan Zhang. (2023) Synthesis of stable and efficient amide-based covalent organic frameworks fiber coatings for the improved solid-phase microextraction of polar aromatic amines. ANALYTICA CHIMICA ACTA, 1284 (20): (342002). [PMID:37996159] [10.1016/j.aca.2023.342002] |
| 2. Lingfeng Xu, Ying Zou, Mei Zeng, Siqi Duan, Kui Wu, Runlin Han, Limin Liu. (2022) Noninvasive Viscosity Detection in Beverages with an Aggregation-Induced Emission-Based Molecular Rotor. ACS Food Science & Technology, 2 (1): (49–56). [PMID:] [10.1021/acsfoodscitech.1c00302] |
| 3. Qingqing Li, Wenmin Zhang, Yuheng Guo, Hui Chen, Qingqing Ding, Lan Zhang. (2021) Oxygenated carbon nanotubes cages coated solid-phase microextraction fiber for selective extraction of migrated aromatic amines from food contact materials. JOURNAL OF CHROMATOGRAPHY A, 1646 (462031). [PMID:33857834] [10.1016/j.chroma.2021.462031] |
| 4. Wang Jun, Wang Yuru, Song Lei, Wang Hua, Wang Jiaming, Li Cuiqin. (2017) Synthesis and antioxidant capacity of a C12-naphthylamine antioxidant in polyethylene. POLYMER BULLETIN, 74 (9): (3689-3705). [PMID:] [10.1007/s00289-017-1917-2] |
| 5. Xiang Han, Dong-En Wang, Sheng Chen, Longlong Zhang, Yadan Guo, Jinyi Wang. (2015) A new rhodamine-based chemosensor for turn-on fluorescent detection of Fe3+. Analytical Methods, 7 (10): (4231-4236). [PMID:] [10.1039/C5AY00568J] |
| 6. Jing Li,Li Xu,Zhi-Guo Shi. (2018-12-12) Waxberry-like hierarchically porous ethyl-bridged hybrid silica microsphere: A substrate for enzyme catalysis and high-performance liquid chromatography.. Journal of chromatography. A, 1587 (79-87). [PMID:30527847] |