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N420568-1ml

1ml

Available within 4-8 weeks(?)

$182.90

Basic Description

Synonyms	1094-61-7 \| beta-Nicotinamide mononucleotide \| nicotinamide mononucleotide \| NMN zwitterion \| beta-NMN \| Nicotinamide ribotide \| nicotinamide nucleotide \| NMN \| beta-nicotinamide D-ribonucleotide \| nicotinamide ribonucleotide \| nicotinamide D-ribonucleotide \| beta-Nicotinamide
Specifications & Purity	10mM in Water
Biochemical and Physiological Mechanisms	Product of the NAMPT reaction and\xa0a key intermediate in the biosynthesis of nicotinamide adenine dinucleotide (NAD + ). Ameliorates glucose intolerance by restoring NAD + levels in high-fat diet (HFD)-induced T2D mice. Enhances hepatic insulin sensitiv
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads
Product Description	A product of the eNAMPT reaction and a NAD+ intermediate β-Nicotinamide mononucleotide (NMN) is used to study binding motifs within RNA aptamers and ribozyme activation processes involving β-nicotinamide mononucleotide (β-NMN)-activated RNA fragments. β-Nicotinamide mononucleotide is a product of the extracellular Nicotinamide phosphoribosyltransferase (eNAMPT) reaction and a key NAD+ intermediate. It ameliorates glucose intolerance by restoring NAD+ levels in HFD-induced T2D mice. It also enhances hepatic insulin sensitivity and restores gene expression related to oxidative stress, inflammatory response, and circadian rhythm, partly through SIRT1 activation.

Associated Targets(Human)

GLUD1 Tbio Glutamate dehydrogenase 1, mitochondrial (0 Activities)

Discover Target: GLUD1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GAPDH Tchem Glyceraldehyde-3-phosphate dehydrogenase (0 Activities)

Discover Target: GAPDH

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

LDHB Tchem L-lactate dehydrogenase B chain (0 Activities)

Discover Target: LDHB

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MDH1 Tchem Malate dehydrogenase, cytoplasmic (0 Activities)

Discover Target: MDH1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

LDHB Tchem L-lactate dehydrogenase B chain (463 Activities)

Discover Target: LDHB

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MDH1 Tchem Malate dehydrogenase cytoplasmic (119 Activities)

Discover Target: MDH1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GAPDH Tchem Glyceraldehyde-3-phosphate dehydrogenase liver (1284 Activities)

Discover Target: GAPDH

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

GLUD1 Glutamate dehydrogenase (27 Activities)

Discover Target: GLUD1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

panE Ketopantoate reductase (28 Activities)

Discover Target: panE

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	[(2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphate
INCHI	InChI=1S/C11H15N2O8P/c12-10(16)6-2-1-3-13(4-6)11-9(15)8(14)7(21-11)5-20-22(17,18)19/h1-4,7-9,11,14-15H,5H2,(H3-,12,16,17,18,19)/t7-,8-,9-,11-/m1/s1
InChi Key	DAYLJWODMCOQEW-TURQNECASA-N
Canonical SMILES	C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)[O-])O)O)C(=O)N
Isomeric SMILES	C1=CC(=C[N+](=C1)[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)(O)[O-])O)O)C(=O)N
WGK Germany	3
PubChem CID	14180
Molecular Weight	334.22
Beilstein	3570187

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

Sensitivity	heat sensitive
Specific Rotation[α]	-24° (C=2,H2O)
Melt Point(°C)	166 °C

Safety and Hazards(GHS)

WGK Germany	3
Merck Index	6663

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Jiyan Xu, Xinlu Chen, Shuai Liu, Ziqi Wei, Minhui Xu, Linhao Jiang, Xue Han, Liangyu Peng, Xiaoping Gu, Tianjiao Xia. (2023) Nicotinamide mononucleotide pretreatment improves long-term isoflurane anesthesia-induced cognitive impairment in mice. BEHAVIOURAL BRAIN RESEARCH, (14): (114738). [PMID:37931707] [10.1016/j.bbr.2023.114738]
2. Qi Shen, Shi-Jia Zhang, Bin-Hui Xu, Zhi-Yu Chen, Feng Peng, Neng Xiong, Ya-Ping Xue, Yu-Guo Zheng. (2023) Semirational engineering of Cytophaga hutchinsonii polyphosphate kinase for developing a cost-effective, robust, and efficient adenosine 5′-triphosphate regeneration system. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, [PMID:37902313] [10.1128/aem.01106-23]
3. Ruixue Duan, Yueping Li, Ruru Zhang, Xuelan Hu, Yi wang, Jianfeng Zeng, Mingyuan Gao. (2023) Reversing Acute Kidney Injury Through Coordinated Interplay of Anti-inflammation and Iron Supplementation. ADVANCED MATERIALS, (2301283). [PMID:37029662] [10.1002/adma.202301283]
4. Zhuhui Chen, Yue Xiong, Ranran Ma, Pei Chen, Le Duan, Shuying Yang, Ineza Urujeni Gisèle, Linjun You, Deli Xiao. (2023) A novel magnetic fluid for ultra-fast and highly efficient extraction of N1-methylnicotinamide in urine samples. NEW JOURNAL OF CHEMISTRY, 47 (16): (7862-7872). [PMID:] [10.1039/D3NJ00488K]
5. Wu Yue, Yang Jingjuan, Xu Chengmei, Li Qiuqi, Ma Yage, Zhao Shenglan, Zhuang Jiachen, Shen Fei, Wang Qianqian, Feng Fengqin, Zhang Xi. (2022) Sea cucumber (Acaudina leucoprocta) peptides extended the lifespan and enhanced antioxidant capacity via DAF-16/DAF-2/SOD-3/OLD-1/PEPT-1 in Caenorhabditis elegans. Frontiers in Nutrition, 9 [PMID:36483922] [10.3389/fnut.2022.1065145]
6. Zhongshi Huang, Ning Li, Shiqin Yu, Weiping Zhang, Tianmeng Zhang, Jingwen Zhou. (2022) Systematic Engineering of Escherichia coli for Efficient Production of Nicotinamide Mononucleotide From Nicotinamide. ACS Synthetic Biology, 11 (9): (2979–2988). [PMID:35977419] [10.1021/acssynbio.2c00100]
7. Jinhui Hu, Ting Wang, Lin Zhou, Shaohua Wei. (2020) A ROS responsive nanomedicine with enhanced photodynamic therapy via dual mechanisms: GSH depletion and biosynthesis inhibition. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 209 (111955). [PMID:32653858] [10.1016/j.jphotobiol.2020.111955]
8. Zhang Weihong, Wang Dan, Wang Jie-Xin, Pu Yuan, Chen Jian-Feng. (2020) High-gravity-assisted emulsification for continuous preparation of waterborne polyurethane nanodispersion with high solids content. Frontiers of Chemical Science and Engineering, 14 (6): (1087-1099). [PMID:] [10.1007/s11705-019-1895-z]
9. Guohan Sun, Shiqiao Wang, Jianfeng Zhou, Jianbin Pan, Yanli Tong, Qinghua Mei, Haiyun Zhai. (2020) Constructing a simple and sensitive electrochemical sensor for the determination of NMN based on p-m-ABSA film modified glassy carbon electrode. MICROCHEMICAL JOURNAL, 152 (104438). [PMID:] [10.1016/j.microc.2019.104438]
10. Dengcheng Huang, Yu Zhou, Yuan Xiang, Meijie Shu, Hongxiang Chen, Bing Yang, Xinghua Liao. (2018) Polyurethane/doxorubicin nanoparticles based on electrostatic interactions as pH-sensitive drug delivery carriers. POLYMER INTERNATIONAL, 67 (9): (1186-1193). [PMID:] [10.1002/pi.5618]
11. Ma Le, Song Lina, Li Fang, Wang Heng, Liu Baohua. (2017) Preparation and properties of poly (propylene carbonate)-based waterborne polyurethane-acrylate composite emulsion. COLLOID AND POLYMER SCIENCE, 295 (12): (2299-2307). [PMID:] [10.1007/s00396-017-4198-2]
12. Caideng Yuan, Mengyao Wang, Haitao Li, Zhongwei Wang. (2017) Preparation and properties of UV-curable waterborne polyurethane–acrylate emulsion. JOURNAL OF APPLIED POLYMER SCIENCE, 134 (34): (45208). [PMID:] [10.1002/app.45208]
13. Di Liu, Guo-Min Wu, Zhen-Wu Kong. (2016) Preparation and characterization of a polydimethylsiloxane-modified, epoxy-resin-based polyol dispersion and its crosslinked films. JOURNAL OF APPLIED POLYMER SCIENCE, 134 (1): [PMID:] [10.1002/app.44342]
14. Sude Ma, Guolin Song, Ningbo Feng. (2012) Preparation and characterization of self-emulsified waterborne nitrocellulose. CARBOHYDRATE POLYMERS, 89 (36). [PMID:24750600] [10.1016/j.carbpol.2012.02.029]

References

1. Jiyan Xu, Xinlu Chen, Shuai Liu, Ziqi Wei, Minhui Xu, Linhao Jiang, Xue Han, Liangyu Peng, Xiaoping Gu, Tianjiao Xia. (2023) Nicotinamide mononucleotide pretreatment improves long-term isoflurane anesthesia-induced cognitive impairment in mice. BEHAVIOURAL BRAIN RESEARCH, (14): (114738). [PMID:37931707] [10.1016/j.bbr.2023.114738]
2. Qi Shen, Shi-Jia Zhang, Bin-Hui Xu, Zhi-Yu Chen, Feng Peng, Neng Xiong, Ya-Ping Xue, Yu-Guo Zheng. (2023) Semirational engineering of Cytophaga hutchinsonii polyphosphate kinase for developing a cost-effective, robust, and efficient adenosine 5′-triphosphate regeneration system. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, [PMID:37902313] [10.1128/aem.01106-23]
3. Ruixue Duan, Yueping Li, Ruru Zhang, Xuelan Hu, Yi wang, Jianfeng Zeng, Mingyuan Gao. (2023) Reversing Acute Kidney Injury Through Coordinated Interplay of Anti-inflammation and Iron Supplementation. ADVANCED MATERIALS, (2301283). [PMID:37029662] [10.1002/adma.202301283]
4. Zhuhui Chen, Yue Xiong, Ranran Ma, Pei Chen, Le Duan, Shuying Yang, Ineza Urujeni Gisèle, Linjun You, Deli Xiao. (2023) A novel magnetic fluid for ultra-fast and highly efficient extraction of N1-methylnicotinamide in urine samples. NEW JOURNAL OF CHEMISTRY, 47 (16): (7862-7872). [PMID:] [10.1039/D3NJ00488K]
5. Wu Yue, Yang Jingjuan, Xu Chengmei, Li Qiuqi, Ma Yage, Zhao Shenglan, Zhuang Jiachen, Shen Fei, Wang Qianqian, Feng Fengqin, Zhang Xi. (2022) Sea cucumber (Acaudina leucoprocta) peptides extended the lifespan and enhanced antioxidant capacity via DAF-16/DAF-2/SOD-3/OLD-1/PEPT-1 in Caenorhabditis elegans. Frontiers in Nutrition, 9 [PMID:36483922] [10.3389/fnut.2022.1065145]
6. Zhongshi Huang, Ning Li, Shiqin Yu, Weiping Zhang, Tianmeng Zhang, Jingwen Zhou. (2022) Systematic Engineering of Escherichia coli for Efficient Production of Nicotinamide Mononucleotide From Nicotinamide. ACS Synthetic Biology, 11 (9): (2979–2988). [PMID:35977419] [10.1021/acssynbio.2c00100]
7. Jinhui Hu, Ting Wang, Lin Zhou, Shaohua Wei. (2020) A ROS responsive nanomedicine with enhanced photodynamic therapy via dual mechanisms: GSH depletion and biosynthesis inhibition. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 209 (111955). [PMID:32653858] [10.1016/j.jphotobiol.2020.111955]
8. Zhang Weihong, Wang Dan, Wang Jie-Xin, Pu Yuan, Chen Jian-Feng. (2020) High-gravity-assisted emulsification for continuous preparation of waterborne polyurethane nanodispersion with high solids content. Frontiers of Chemical Science and Engineering, 14 (6): (1087-1099). [PMID:] [10.1007/s11705-019-1895-z]
9. Guohan Sun, Shiqiao Wang, Jianfeng Zhou, Jianbin Pan, Yanli Tong, Qinghua Mei, Haiyun Zhai. (2020) Constructing a simple and sensitive electrochemical sensor for the determination of NMN based on p-m-ABSA film modified glassy carbon electrode. MICROCHEMICAL JOURNAL, 152 (104438). [PMID:] [10.1016/j.microc.2019.104438]
10. Dengcheng Huang, Yu Zhou, Yuan Xiang, Meijie Shu, Hongxiang Chen, Bing Yang, Xinghua Liao. (2018) Polyurethane/doxorubicin nanoparticles based on electrostatic interactions as pH-sensitive drug delivery carriers. POLYMER INTERNATIONAL, 67 (9): (1186-1193). [PMID:] [10.1002/pi.5618]
11. Ma Le, Song Lina, Li Fang, Wang Heng, Liu Baohua. (2017) Preparation and properties of poly (propylene carbonate)-based waterborne polyurethane-acrylate composite emulsion. COLLOID AND POLYMER SCIENCE, 295 (12): (2299-2307). [PMID:] [10.1007/s00396-017-4198-2]
12. Caideng Yuan, Mengyao Wang, Haitao Li, Zhongwei Wang. (2017) Preparation and properties of UV-curable waterborne polyurethane–acrylate emulsion. JOURNAL OF APPLIED POLYMER SCIENCE, 134 (34): (45208). [PMID:] [10.1002/app.45208]
13. Di Liu, Guo-Min Wu, Zhen-Wu Kong. (2016) Preparation and characterization of a polydimethylsiloxane-modified, epoxy-resin-based polyol dispersion and its crosslinked films. JOURNAL OF APPLIED POLYMER SCIENCE, 134 (1): [PMID:] [10.1002/app.44342]
14. Sude Ma, Guolin Song, Ningbo Feng. (2012) Preparation and characterization of self-emulsified waterborne nitrocellulose. CARBOHYDRATE POLYMERS, 89 (36). [PMID:24750600] [10.1016/j.carbpol.2012.02.029]

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β-Nicotinamide Mononucleotide (NMN) - 10mM in Water, high purity