Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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B140555-25mg | 25mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $252.90 | |
B140555-100mg | 100mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $909.90 |
Apoptosis inducer and precursor to paclitaxel/taxol
Synonyms | AS-35071 | Baccatin cento | CS-0013149 | OVMSOCFBDVBLFW-VHLOTGQHSA-N | BACCATIN III [WHO-DD] | CHEBI:32898 | NSC-330753 | 7,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-one, 6,12b-bis(acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahyd |
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Specifications & Purity | ≥95% |
Biochemical and Physiological Mechanisms | Apoptosis inducer and precursor to paclitaxel/taxol. Stabilises microtubules. Exerts immunomodulatory activities on MHC-restricted antigen presentation. Active in vitro and in vivo . |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Baccatin III is the precursor to paclitaxel/ taxol. Antileukaemic and antitumor agent isolated from the bark of the Pacific yew tree (Taxus breviofolia). Baccatin III binds to tubules when they are assembled in the cell and stabilizes the polymerized form of tubules so that they remain assembled even under conditions in which microtubules dissociate into tubulin subunits. Baccatin III is also an inducer of apoptosis and shows antitumor properties in vitro |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Acetylcholinesterase inhibitor | INHIBITOR | ALA220 | Acetylcholinesterase | SINGLE PROTEIN | Homo sapiens | DailyMed: [1] | |
Acetylcholinesterase inhibitor | INHIBITOR | ALA220 | Acetylcholinesterase | SINGLE PROTEIN | Homo sapiens | DailyMed: [1] | |
Acetylcholinesterase inhibitor | INHIBITOR | ALA220 | Acetylcholinesterase | SINGLE PROTEIN | Homo sapiens | ||
Acetylcholinesterase inhibitor | INHIBITOR | ALA220 | Acetylcholinesterase | SINGLE PROTEIN | Homo sapiens | ||
Acetylcholinesterase inhibitor | INHIBITOR | ALA220 | Acetylcholinesterase | SINGLE PROTEIN | Homo sapiens | DailyMed: [1] | |
Acetylcholinesterase inhibitor | INHIBITOR | ALA220 | Acetylcholinesterase | SINGLE PROTEIN | Homo sapiens | ||
Acetylcholinesterase inhibitor | INHIBITOR | ALA220 | Acetylcholinesterase | SINGLE PROTEIN | Homo sapiens | DailyMed: [1] | |
Acetylcholinesterase inhibitor | INHIBITOR | ALA220 | Acetylcholinesterase | SINGLE PROTEIN | Homo sapiens | ||
Acetylcholinesterase inhibitor | INHIBITOR | ALA220 | Acetylcholinesterase | SINGLE PROTEIN | Homo sapiens | PubMed: [1] | |
Acetylcholinesterase inhibitor | INHIBITOR | ALA220 | Acetylcholinesterase | SINGLE PROTEIN | Homo sapiens | FDA: [1] |
IUPAC Name | [(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-diacetyloxy-1,9,15-trihydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate |
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INCHI | InChI=1S/C31H38O11/c1-15-19(34)13-31(38)26(41-27(37)18-10-8-7-9-11-18)24-29(6,20(35)12-21-30(24,14-39-21)42-17(3)33)25(36)23(40-16(2)32)22(15)28(31,4)5/h7-11,19-21,23-24,26,34-35,38H,12-14H2,1-6H3/t19-,20-,21+,23+,24-,26-,29+,30-,31+/m0/s1 |
InChi Key | OVMSOCFBDVBLFW-VHLOTGQHSA-N |
Canonical SMILES | CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1O)O)OC(=O)C5=CC=CC=C5)(CO4)OC(=O)C)O)C)OC(=O)C |
Isomeric SMILES | CC1=C2[C@H](C(=O)[C@@]3([C@H](C[C@@H]4[C@]([C@H]3[C@@H]([C@@](C2(C)C)(C[C@@H]1O)O)OC(=O)C5=CC=CC=C5)(CO4)OC(=O)C)O)C)OC(=O)C |
WGK Germany | 3 |
PubChem CID | 65366 |
Molecular Weight | 586.63 |
Find and download the COA for your product by matching the lot number on the packaging.
1 results found
Lot Number | Certificate Type | Date | Item |
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I1518087 | Certificate of Analysis | May 08, 2023 | B140555 |
Solubility | Soluble in DMSO, 100% ethanol, and methanol. |
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Refractive Index | 1.5455-1.5475 |
Melt Point(°C) | 229-234°C |
Pictogram(s) | GHS08, GHS07 |
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Signal | Danger |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H350:May cause cancer |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P318:if exposed or concerned, get medical advice. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |
1. Yu Chunna, Luo Xiujun, Zhan Xiaori, Hao Juan, Zhang Lei, L Song Yao-Bin, Shen Chenjia, Dong Ming. (2018) Comparative metabolomics reveals the metabolic variations between two endangered Taxus species (T. fuana and T. yunnanensis) in the Himalayas. BMC PLANT BIOLOGY, 18 (1): (1-12). [PMID:30223770] [10.1186/s12870-018-1412-4] |
2. Fei Qiao, Hanqing Cong, Xuefei Jiang, Rongxiang Wang, Junmei Yin, Dan Qian, Zhunian Wang, Peter Nick. (2014) De Novo Characterization of a Cephalotaxus hainanensis Transcriptome and Genes Related to Paclitaxel Biosynthesis. PLoS One, 9 (9): (e106900). [PMID:25203398] [10.1371/journal.pone.0106900] |
1. Yu Chunna, Luo Xiujun, Zhan Xiaori, Hao Juan, Zhang Lei, L Song Yao-Bin, Shen Chenjia, Dong Ming. (2018) Comparative metabolomics reveals the metabolic variations between two endangered Taxus species (T. fuana and T. yunnanensis) in the Himalayas. BMC PLANT BIOLOGY, 18 (1): (1-12). [PMID:30223770] [10.1186/s12870-018-1412-4] |
2. Fei Qiao, Hanqing Cong, Xuefei Jiang, Rongxiang Wang, Junmei Yin, Dan Qian, Zhunian Wang, Peter Nick. (2014) De Novo Characterization of a Cephalotaxus hainanensis Transcriptome and Genes Related to Paclitaxel Biosynthesis. PLoS One, 9 (9): (e106900). [PMID:25203398] [10.1371/journal.pone.0106900] |