Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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X138043-1g | 1g | In stock | $75.90 | |
X138043-5g | 5g | In stock | $284.90 | |
X138043-25g | 25g | In stock | $1,282.90 | |
X138043-100g | 100g | In stock | $4,617.90 |
GABA B agonist
Synonyms | baclofen | 1134-47-0 | Lioresal | 4-Amino-3-(4-chlorophenyl)butanoic acid | Baclon | Kemstro | DL-Baclofen | Gabalon | (+-)-Baclofen | Baclofenum | Baclofene | Baclofeno | Baclophen | Lioresal Intrathecal | (RS)-BACLOFEN | 4-Amino-3-(4-chlorophenyl)butyric acid | beta-(4-Chlorophenyl)ga |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Selective GABA B receptor agonist. Antispasmodic. |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Grade | Moligand™ |
Action Type | AGONIST |
Mechanism of action | GABA-B receptor agonist |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | A selective agonist of the GABAB receptor. |
ALogP | -1 |
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IUPAC Name | 4-amino-3-(4-chlorophenyl)butanoic acid |
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INCHI | InChI=1S/C10H12ClNO2/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14/h1-4,8H,5-6,12H2,(H,13,14) |
InChi Key | KPYSYYIEGFHWSV-UHFFFAOYSA-N |
Canonical SMILES | C1=CC(=CC=C1C(CC(=O)O)CN)Cl |
Isomeric SMILES | C1=CC(=CC=C1C(CC(=O)O)CN)Cl |
WGK Germany | 3 |
RTECS | MW5084200 |
PubChem CID | 2284 |
UN Number | 2811 |
Packing Group | I |
Molecular Weight | 213.66 |
Reaxy-Rn | 2104494 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
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J1614068 | Certificate of Analysis | Feb 26, 2024 | X138043 |
L2121631 | Certificate of Analysis | Oct 08, 2023 | X138043 |
L2121633 | Certificate of Analysis | Oct 08, 2023 | X138043 |
L2121636 | Certificate of Analysis | Oct 08, 2023 | X138043 |
L2121638 | Certificate of Analysis | Oct 08, 2023 | X138043 |
Solubility | Soluble in water (pH 7.6) (4.3 mg/ml), dilute aqueous acid (> 20 mg/ml), dilute aqueous base (>20 mg/ml), ethanol (0.02 mg/ml), and methanol (slightly soluble). Insoluble in acetone, chloroform, and ether. |
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Melt Point(°C) | 208°C(lit.) |
Pictogram(s) | GHS06, GHS08, GHS07 |
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Signal | Danger |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H301:Toxic if swallowed H317:May cause an allergic skin reaction H334:May cause allergy or asthma symptoms or breathing difficulties if inhaled H336:May cause drowsiness or dizziness H360:May damage fertility or the unborn child H361:Suspected of damaging fertility or the unborn child |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P284:[In case of inadequate ventilation] Wear respiratory protection. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P318:if exposed or concerned, get medical advice. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. P342+P316:If experiencing respiratory symptoms: Get emergence medical help immediately. |
WGK Germany | 3 |
RTECS | MW5084200 |
Reaxy-Rn | 2104494 |
Class | 6.1 |
Merck Index | 937 |
1. Cai F,Xu N,Liu Z,Ding R,Yu S,Dong M,Wang S,Shen J,Tae HS,Adams DJ,Zhang X,Dai Q. (2018) Targeting of N-Type Calcium Channels via GABA-Receptor Activation by α-Conotoxin Vc1.1 Variants Displaying Improved Analgesic Activity.. J Med Chem, 61 (22): (10198-10205). [PMID:30358401] |
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4. Cai F,Xu N,Liu Z,Ding R,Yu S,Dong M,Wang S,Shen J,Tae HS,Adams DJ,Zhang X,Dai Q. (2018) Targeting of N-Type Calcium Channels via GABA-Receptor Activation by α-Conotoxin Vc1.1 Variants Displaying Improved Analgesic Activity.. J Med Chem, 61 (22): (10198-10205). [PMID:30358401] |