Basic Description

Synonyms	bafilomycin A1 \| 88899-55-2 \| CHEMBL290814 \| CHEBI:22689 \| MFCD06795130 \| (3Z,5E,7R,8S,9S,11E,13E,15S,16R)-16-{(2S,3R,4S)-4-[(2R,4R,5S,6R)-2,4-dihydroxy-6-isopropyl-5-methyltetrahydro-2H-pyran-2-yl]-3-hydroxypentan-2-yl}-8-hydroxy-3,15-dimethoxy-5,7,9,11-tetramethy
Specifications & Purity	≥95%
Biochemical and Physiological Mechanisms	A specific inhibitor of vacuolar type H+-ATPase (V-ATPase) in animal cells, plant cells and microorganisms.Highly potent, selective vacuolar (V)-ATPase inhibitor (IC 50 = 500 pM in chromaffin granule membranes). Induces vacuolar deacidification and promot
Storage Temp	Store at -20°C,Argon charged
Shipped In	Ice chest + Ice pads
Note	This product is supplied in one (or more) pack size which is freeze dried. Therefore the contents may not be readily visible, as they can coat the bottom or walls of the vial. Please see our FAQs and information page for more details on handling. Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Bafilomycin A1 is a potent and selective inhibitor of V-ATPase (vacuolar-type (v-type) H+ ATPase) and belongs to a class of membrane ATPase inhibitors. The compound can inhibit E1E2 ATPases from sarcoplasmic reticulum, Escherichia coli, and ox brain versus F1F0 ATPases found in bacteria and mitochondria. Some of the more bafilomycin A1 affected ATPases include Neurospora and plant vacuoles, as well as chromaffin granules. Additionally, Bafilomycin A1 prevents lysosomal cholesterol trafficking in macrophages and can be used to distinguish different types of ATPases. Research shows that Bafilomycin A1 can inhibit macroautophagy and promote apoptosis in colon cancer cells. A macrolide antibiotic and potent and selective inhibitor of vacuolar-type (v-type) H+ ATPase

Associated Targets(Human)

ATP6AP1 Tchem V-type proton ATPase subunit S1 (1 Activities)

Discover Target: ATP6AP1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

P2RX3 Tclin P2X purinoceptor 3 (1 Activities)

Discover Target: P2RX3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ELANE Tclin Leukocyte elastase (8173 Activities)

Discover Target: ELANE

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ADORA3 Tchem Adenosine A3 receptor (15931 Activities)

Discover Target: ADORA3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CTSB Tchem Cathepsin B (3822 Activities)

Discover Target: CTSB

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ATP6AP1 Tchem Vacuolar ATP synthase subunit S1 (39 Activities)

Discover Target: ATP6AP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

BGC-823 (3035 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Caco-2 (12174 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MCF7 (126967 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PC-3 (62116 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

A549 (127892 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

NCI-H460 (60772 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HeLa (62764 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SMMC-7721 (5516 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TAOK2 Tchem Serine/threonine-protein kinase TAO2 (964 Activities)

Discover Target: TAOK2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

ATP6V1B2 Vacuolar H(+)-ATPase (27 Activities)

Discover Target: ATP6V1B2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

P2rx3 P2X purinoceptor 3 (632 Activities)

Discover Target: P2rx3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

VATB Adenosinetriphosphatase (4 Activities)

Discover Target: VATB

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Salmonella typhimurium (15756 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Staphylococcus aureus (210822 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Escherichia coli (133304 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Cryptococcus neoformans (21258 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Candida albicans (78123 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Candida parapsilosis (8521 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Hepatitis C virus (23859 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Murine hepatitis virus (113 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Influenza A virus (11224 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MDCK (10148 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RAW264.7 (28094 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

3Y1 cell line (119 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

H4 (48 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Bacillus spizizenii (1898 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	(3Z,5E,7R,8S,9S,11E,13E,15S,16R)-16-[(2S,3R,4S)-4-[(2R,4R,5S,6R)-2,4-dihydroxy-5-methyl-6-propan-2-yloxan-2-yl]-3-hydroxypentan-2-yl]-8-hydroxy-3,15-dimethoxy-5,7,9,11-tetramethyl-1-oxacyclohexadeca-3,5,11,13-tetraen-2-one
INCHI	InChI=1S/C35H58O9/c1-19(2)32-24(7)27(36)18-35(40,44-32)26(9)31(38)25(8)33-28(41-10)14-12-13-20(3)15-22(5)30(37)23(6)16-21(4)17-29(42-11)34(39)43-33/h12-14,16-17,19,22-28,30-33,36-38,40H,15,18H2,1-11H3/b14-12+,20-13+,21-16+,29-17-/t22-,23+,24-,25-,26-,27+,28-,30-,31+,32+,33+,35+/m0/s1
InChi Key	XDHNQDDQEHDUTM-JQWOJBOSSA-N
Canonical SMILES	CC1CC(=CC=CC(C(OC(=O)C(=CC(=CC(C1O)C)C)OC)C(C)C(C(C)C2(CC(C(C(O2)C(C)C)C)O)O)O)OC)C
Isomeric SMILES	C[C@H]1C/C(=C/C=C/[C@@H]([C@H](OC(=O)/C(=C/C(=C/[C@H]([C@H]1O)C)/C)/OC)[C@@H](C)[C@H]([C@H](C)[C@]2(C[C@H]([C@@H]([C@H](O2)C(C)C)C)O)O)O)OC)/C
WGK Germany	3
PubChem CID	6436223
Molecular Weight	622.83
Beilstein	4730700

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

2 results found

Lot Number	Certificate Type	Date	Item
K2230658	Certificate of Analysis	Oct 11, 2022	B101389
K2230698	Certificate of Analysis	Oct 11, 2022	B101389

Chemical and Physical Properties

Solubility	Soluble in methanol, ethanol (0.1 mg/ml), DMSO (0.1 mg/ml), acetone, and chloroform. Insoluble in water.,
Sensitivity	Light & Heat sensitive

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.
WGK Germany	3

Citations of This Product

1. Tao Long, Xue Chen, Yue Zhang, Yu-Jia Zhou, Yan-Ni He, Yun-Fei Zhu, Hai-Jun Fu, Lu Yu, Chong-Lin Yu, Betty Yuen-Kwan Law, Jian-Ming Wu, Da-Lian Qin, An-Guo Wu, Xiao-Gang Zhou. (2023) Protective effects of Radix Stellariae extract against Alzheimer's disease via autophagy activation in Caenorhabditis elegans and cellular models. BIOMEDICINE & PHARMACOTHERAPY, 165 (115261). [PMID:37549461]
2. Yaru Zou, Wei Gao, Huizhen Jin, Chenmei Mao, Yi Zhang, Xiaoling Wang, Dong Mei, Libo Zhao. (2023) Cellular Uptake and Transport Mechanism of 6-Mercaptopurine Nanomedicines for Enhanced Oral Bioavailability. International Journal of Nanomedicine, [PMID:36636639]
3. Weizhou Sha, Mingzhu Wang, Wei Wang, Zhi Yuan. (2022) pH-Responsive nanoprobes for tumour fluorescence imaging based on spirolactam rhodamine. Materials Chemistry Frontiers, 6 (19): (2869-2879). [PMID:]
4. Weibo Zhang, Shucheng Zhang, Chong Chen, Ning Liu, Dong Yang, Pengjie Wang, Fazheng Ren. (2022) The internalization mechanisms and trafficking of the pea albumin in Caco-2 cells. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 217 (111). [PMID:35764167]
5. Tao Long, Qian Wu, Jing Wei, Yong Tang, Yan-Ni He, Chang-Long He, Xue Chen, Lu Yu, Chong-Lin Yu, Betty Yuen-Kwan Law, Jian-Ming Wu, Da-Lian Qin, An-Guo Wu, Xiao-Gang Zhou. (2022) Ferulic Acid Exerts Neuroprotective Effects via Autophagy Induction in C. elegans and Cellular Models of Parkinson’s Disease. Oxidative Medicine and Cellular Longevity, 2022 (3723567). [PMID:35242276]
6. Hongxi Wu, Guodong Li, Weiwei Chen, Wenbin Luo, Zhongyi Yang, Zhipeng You, Yuling Zou. (2022) Drp1 knockdown represses apoptosis of rat retinal endothelial cells by inhibiting mitophagy. ACTA HISTOCHEMICA, 124 (151837). [PMID:34959219]
7. Ying Zhang, Qian Liu, Mengting Liu, Xueni Zhang, Xiaoya Li, Lihui Dai, Meng Meng, Dingbin Liu, Yongmei Yin, Rimo Xi. (2022) Dual functional molecule aided background-free SERS sensor for intracellular pH dynamic monitoring based on foldable DNA transition. SENSORS AND ACTUATORS B-CHEMICAL, 353 (131162). [PMID:]
8. Li D et al.. (2021) Sulforaphane Activates a lysosome-dependent transcriptional program to mitigate oxidative stress.. Autophagy, 17 (4): (872-887). [PMID:32138578]

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B101389-1mg	1mg	In stock	$414.90
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Bafilomycin A1 - ≥95.0 %, high purity , CAS No.88899-55-2