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BAN ORL 24 - ≥98%, high purity , CAS No.475150-69-7, Antagonist of NOP receptor

  • Moligand™
  • ≥98%
Item Number
B339601
Grouped product items
SKUSizeAvailabilityPrice Qty
B339601-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$175.90
B339601-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$753.90
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a KOR-3 (NOP) antagonist

View related series
NOP receptor Antagonist

Basic Description

Specifications & PurityMoligand™, ≥98%
Storage TempRoom temperature,Desiccated
Shipped InNormal
GradeMoligand™
Action TypeANTAGONIST
Mechanism of actionAntagonist of NOP receptor
Product Description

BAN ORL 24 is a potent and selective NOP (also known as KOR-3) receptor antagonist (IC|50|values are 0.27, 2500, 6700 and > 10000 nM for NOP, κ-, μ- and δ-receptors respectively). BAN ORL 24 Inhibits nociceptin-induced stimulation of [35S]-GTPγS binding and Ca|2+|mobilization in CHO cells|in vitro|and antagonizes NOP agonist-induced reduction in locomotor activity|in vivo|.BAN ORL 24 can is also a brain penetrant.

Associated Targets

HDAC6 Tclin Histone deacetylase 6 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

OPRD1 Tclin Delta-type opioid receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

OPRK1 Tclin Kappa-type opioid receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

OPRL1 Tchem Nociceptin receptor 4 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

OPRM1 Tclin Mu-type opioid receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name (2R)-1-benzyl-N-(3-spiro[1H-2-benzofuran-3,4'-piperidine]-1'-ylpropyl)pyrrolidine-2-carboxamide
INCHI InChI=1S/C27H35N3O2/c31-26(25-12-6-17-30(25)20-22-8-2-1-3-9-22)28-15-7-16-29-18-13-27(14-19-29)24-11-5-4-10-23(24)21-32-27/h1-5,8-11,25H,6-7,12-21H2,(H,28,31)/t25-/m1/s1
InChi Key MAKMQGKJURAJEN-RUZDIDTESA-N
Canonical SMILES C1CC(N(C1)CC2=CC=CC=C2)C(=O)NCCCN3CCC4(CC3)C5=CC=CC=C5CO4
Isomeric SMILES C1C[C@@H](N(C1)CC2=CC=CC=C2)C(=O)NCCCN3CCC4(CC3)C5=CC=CC=C5CO4
PubChem CID 10296561
Molecular Weight 433.59

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

SolubilitySoluble in water (100 mM), and DMSO (100 mM).
Specific Rotation[α]α20/D +10°, c = 1 in water

Related Documents

 SDS

 Specification Sheet

References

1. Goto Y, Arai-Otsuki S, Tachibana Y, Ichikawa D, Ozaki S, Takahashi H, Iwasawa Y, Okamoto O, Okuda S, Ohta H et al..  (2006)  Identification of a novel spiropiperidine opioid receptor-like 1 antagonist class by a focused library approach featuring 3D-pharmacophore similarity..  J Med Chem,  49  (3): (847-9).  [PMID:16451050]

Solution Calculators

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