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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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B607930-1mg | 1mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $12.90 | |
B607930-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $49.90 | |
B607930-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $69.90 | |
B607930-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $119.90 | |
B607930-50mg | 50mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $199.90 | |
B607930-100mg | 100mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $279.90 |
Synonyms | DB11877 | EX-A1272 | (1,1-dioxo-1,4-thiazinan-4-yl)-[6-[[3-(4-fluorophenyl)-5-methyl-1,2-oxazol-4-yl]methoxy]pyridin-3-yl]methanone | (1,1-Dioxo-4-thiomorpholinyl)(6-((3-(4-fluorophenyl)-5-methylisoxazol-4-yl)methoxy)pyridin-3-yl)methanone | AC-35398 | Ba |
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Specifications & Purity | Moligand™, ≥98% |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | ALLOSTERIC MODULATOR |
Mechanism of action | Allosteric modulator of GABA A receptor α5 subunit |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | (1,1-dioxo-1,4-thiazinan-4-yl)-[6-[[3-(4-fluorophenyl)-5-methyl-1,2-oxazol-4-yl]methoxy]pyridin-3-yl]methanone |
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INCHI | InChI=1S/C21H20FN3O5S/c1-14-18(20(24-30-14)15-2-5-17(22)6-3-15)13-29-19-7-4-16(12-23-19)21(26)25-8-10-31(27,28)11-9-25/h2-7,12H,8-11,13H2,1H3 |
InChi Key | VCGRFBXVSFAGGA-UHFFFAOYSA-N |
Canonical SMILES | CC1=C(C(=NO1)C2=CC=C(C=C2)F)COC3=NC=C(C=C3)C(=O)N4CCS(=O)(=O)CC4 |
Isomeric SMILES | CC1=C(C(=NO1)C2=CC=C(C=C2)F)COC3=NC=C(C=C3)C(=O)N4CCS(=O)(=O)CC4 |
Alternate CAS | 1646183-13-2,1159600-41-5 |
PubChem CID | 57336276 |
MeSH Entry Terms | (1,1-Dioxido-4-thiomorpholinyl)(6-((3-(4-fluorophenyl)-5-methyl-1,2-oxazol-4-yl)methoxy)-3-pyridinyl)methanone;basmisanil |
Molecular Weight | 445.46 |
PubChem CID | 57336276 |
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BindingDB Ligand | BDBM133427 |
DrugBank Ligand | DB11877 |
ChEMBL Ligand | CHEMBL3681419 |
CAS Registry No. | 1159600-41-5 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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E2422215 | Certificate of Analysis | Feb 23, 2024 | B607930 |
E2422216 | Certificate of Analysis | Feb 23, 2024 | B607930 |
E2422217 | Certificate of Analysis | Feb 23, 2024 | B607930 |
E2422218 | Certificate of Analysis | Feb 23, 2024 | B607930 |
E2422219 | Certificate of Analysis | Feb 23, 2024 | B607930 |
E2422220 | Certificate of Analysis | Feb 23, 2024 | B607930 |
E2422221 | Certificate of Analysis | Feb 23, 2024 | B607930 |
E2422222 | Certificate of Analysis | Feb 23, 2024 | B607930 |
E2422223 | Certificate of Analysis | Feb 23, 2024 | B607930 |
E2422224 | Certificate of Analysis | Feb 23, 2024 | B607930 |
E2422225 | Certificate of Analysis | Feb 23, 2024 | B607930 |
E2422226 | Certificate of Analysis | Feb 23, 2024 | B607930 |
1. Costa AC, Scott-McKean JJ. (2013) Prospects for improving brain function in individuals with Down syndrome.. CNS Drugs, 27 (9): (679-702). [PMID:23821040] [10.1021/op500134e] |
2. Myers JF, Comley RA, Gunn RN. (2017) Quantification of [11C]Ro15-4513 GABAAα5 specific binding and regional selectivity in humans.. J Cereb Blood Flow Metab, 37 (6): (2137-2148). [PMID:27466376] [10.1021/op500134e] |