Basmisanil - 98%, high purity , CAS No.1159600-41-5, Allosteric modulator of GABA A receptor α5 subunit

Item Number
B607930
Grouped product items
SKUSizeAvailabilityPrice Qty
B607930-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$12.90
B607930-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$49.90
B607930-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$69.90
B607930-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$119.90
B607930-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$199.90
B607930-100mg
100mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$279.90

Basic Description

SynonymsDB11877 | EX-A1272 | (1,1-dioxo-1,4-thiazinan-4-yl)-[6-[[3-(4-fluorophenyl)-5-methyl-1,2-oxazol-4-yl]methoxy]pyridin-3-yl]methanone | (1,1-Dioxo-4-thiomorpholinyl)(6-((3-(4-fluorophenyl)-5-methylisoxazol-4-yl)methoxy)pyridin-3-yl)methanone | AC-35398 | Ba
Specifications & PurityMoligand™, ≥98%
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeALLOSTERIC MODULATOR
Mechanism of actionAllosteric modulator of GABA A receptor α5 subunit

Associated Targets(Human)

GABRA1 Tclin Gamma-aminobutyric acid receptor subunit alpha-1 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GABRA3 Tclin Gamma-aminobutyric acid receptor subunit alpha-3 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GABRA5 Tclin Gamma-aminobutyric acid receptor subunit alpha-5 (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GABRA2 Tclin Gamma-aminobutyric acid receptor subunit alpha-2 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GABRA1 Tclin GABA receptor alpha-1 subunit (399 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GABRA5 Tclin GABA receptor alpha-5 subunit (699 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GABRA3 Tclin GABA receptor alpha-3 subunit (187 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GABRA2 Tclin GABA receptor alpha-2 subunit (271 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
U2OS (164939 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GABRA1 Tclin GABA-A receptor; alpha-1/beta-3/gamma-2 (1565 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GABRG2 Tclin GABA-A receptor; alpha-5/beta-3/gamma-2 (1334 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HEK-293T (167025 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name (1,1-dioxo-1,4-thiazinan-4-yl)-[6-[[3-(4-fluorophenyl)-5-methyl-1,2-oxazol-4-yl]methoxy]pyridin-3-yl]methanone
INCHI InChI=1S/C21H20FN3O5S/c1-14-18(20(24-30-14)15-2-5-17(22)6-3-15)13-29-19-7-4-16(12-23-19)21(26)25-8-10-31(27,28)11-9-25/h2-7,12H,8-11,13H2,1H3
InChi Key VCGRFBXVSFAGGA-UHFFFAOYSA-N
Canonical SMILES CC1=C(C(=NO1)C2=CC=C(C=C2)F)COC3=NC=C(C=C3)C(=O)N4CCS(=O)(=O)CC4
Isomeric SMILES CC1=C(C(=NO1)C2=CC=C(C=C2)F)COC3=NC=C(C=C3)C(=O)N4CCS(=O)(=O)CC4
Alternate CAS 1646183-13-2,1159600-41-5
PubChem CID 57336276
MeSH Entry Terms (1,1-Dioxido-4-thiomorpholinyl)(6-((3-(4-fluorophenyl)-5-methyl-1,2-oxazol-4-yl)methoxy)-3-pyridinyl)methanone;basmisanil
Molecular Weight 445.46

Certificates

Certificate of Analysis(COA)

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12 results found

Lot NumberCertificate TypeDateItem
E2422215Certificate of AnalysisFeb 23, 2024 B607930
E2422216Certificate of AnalysisFeb 23, 2024 B607930
E2422217Certificate of AnalysisFeb 23, 2024 B607930
E2422218Certificate of AnalysisFeb 23, 2024 B607930
E2422219Certificate of AnalysisFeb 23, 2024 B607930
E2422220Certificate of AnalysisFeb 23, 2024 B607930
E2422221Certificate of AnalysisFeb 23, 2024 B607930
E2422222Certificate of AnalysisFeb 23, 2024 B607930
E2422223Certificate of AnalysisFeb 23, 2024 B607930
E2422224Certificate of AnalysisFeb 23, 2024 B607930
E2422225Certificate of AnalysisFeb 23, 2024 B607930
E2422226Certificate of AnalysisFeb 23, 2024 B607930

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Related Documents

References

1. Costa AC, Scott-McKean JJ.  (2013)  Prospects for improving brain function in individuals with Down syndrome..  CNS Drugs,  27  (9): (679-702).  [PMID:23821040] [10.1021/op500134e]
2. Myers JF, Comley RA, Gunn RN.  (2017)  Quantification of [11C]Ro15-4513 GABAAα5 specific binding and regional selectivity in humans..  J Cereb Blood Flow Metab,  37  (6): (2137-2148).  [PMID:27466376] [10.1021/op500134e]

Solution Calculators