Determine the necessary mass, volume, or concentration for preparing a solution.
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Basic Description
| Synonyms | Bathophenanthrolin [German] | NCI60_012508 | NSC637659 | NSC-637659 | DTXSID7061857 | 4,7-diphenyl-phenanthroline | Disofen | GNF-Pf-4554 | 4A2B091F0G | F16258 | STL557554 | 4,7-Diphenyl-1,10-phenanthroline, 98.5% | B-0400 | BIDD:GT0407 | EINECS 216-767-1 |
|---|---|
| Specifications & Purity | ≥99% |
| Shipped In | Normal |
| Product Description | This is used as a bidentate ligand and for determination of iron. |
Associated Targets(Human)
A498 (42825 Activities)
ACHN (49357 Activities)
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CCRF-CEM (65223 Activities)
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COLO 205 (50209 Activities)
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DLD-1 (17511 Activities)
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DMS-273 (14108 Activities)
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HL-60 (67320 Activities)
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HT-29 (80576 Activities)
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Huh-7 (12904 Activities)
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K562 (73714 Activities)
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KM12 (47707 Activities)
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M14 (47487 Activities)
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MOLT-4 (49676 Activities)
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OVCAR-3 (48710 Activities)
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OVCAR-4 (44535 Activities)
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OVCAR-5 (45555 Activities)
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OVCAR-8 (47708 Activities)
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RXF 393 (41971 Activities)
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RXF 631 (11415 Activities)
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SK-MEL-2 (46422 Activities)
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SK-MEL-28 (48833 Activities)
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SK-MEL-5 (47095 Activities)
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SK-OV-3 (52876 Activities)
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SN12C (47755 Activities)
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SNB-19 (46794 Activities)
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SNB-78 (14240 Activities)
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TK-10 (45540 Activities)
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U-251 (51189 Activities)
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UACC-257 (46019 Activities)
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UACC-62 (47335 Activities)
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UO-31 (46270 Activities)
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786-0 (47912 Activities)
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A549 (127892 Activities)
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EKVX (44102 Activities)
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NCI-H322M (45589 Activities)
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HCC 2998 (41480 Activities)
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HCT-116 (91556 Activities)
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HOP-18 (11577 Activities)
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NCI-H460 (60772 Activities)
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SF-268 (49410 Activities)
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IGROV-1 (47897 Activities)
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KM-20L2 (14967 Activities)
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LOX IMVI (44321 Activities)
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HOP-62 (47048 Activities)
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LXFL 529 (14112 Activities)
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M19-MEL (15326 Activities)
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Malme-3M (44254 Activities)
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SNB-75 (44215 Activities)
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NCI-H226 (44470 Activities)
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NCI-H23 (49055 Activities)
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Associated Targets(non-human)
Plasmodium falciparum (966862 Activities)
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Plasmodium berghei (192651 Activities)
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Mechanisms of Action
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Names and Identifiers
| Pubchem Sid | 488184716 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488184716 |
| IUPAC Name | 4,7-diphenyl-1,10-phenanthroline |
| INCHI | InChI=1S/C24H16N2/c1-3-7-17(8-4-1)19-13-15-25-23-21(19)11-12-22-20(14-16-26-24(22)23)18-9-5-2-6-10-18/h1-16H |
| InChi Key | DHDHJYNTEFLIHY-UHFFFAOYSA-N |
| Canonical SMILES | C1=CC=C(C=C1)C2=C3C=CC4=C(C=CN=C4C3=NC=C2)C5=CC=CC=C5 |
| Isomeric SMILES | C1=CC=C(C=C1)C2=C3C=CC4=C(C=CN=C4C3=NC=C2)C5=CC=CC=C5 |
| WGK Germany | 3 |
| RTECS | SF8427000 |
| PubChem CID | 72812 |
| Molecular Weight | 332.4 |
| Beilstein | 261048 |
| Reaxy-Rn | 261048 |
Certificates
Certificate of Analysis(COA)
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 E2409184 | Certificate of Analysis | Apr 19, 2024 | D113483 |
| E2409183 | Certificate of Analysis | Apr 19, 2024 | D113483 |
| E2409182 | Certificate of Analysis | Apr 19, 2024 | D113483 |
| L2312129 | Certificate of Analysis | Nov 24, 2023 | D113483 |
| L2312128 | Certificate of Analysis | Nov 24, 2023 | D113483 |
| I2319310 | Certificate of Analysis | Sep 01, 2023 | D113483 |
| I2319309 | Certificate of Analysis | Sep 01, 2023 | D113483 |
| I2319304 | Certificate of Analysis | Sep 01, 2023 | D113483 |
| I2319285 | Certificate of Analysis | Sep 01, 2023 | D113483 |
| I2319283 | Certificate of Analysis | Sep 01, 2023 | D113483 |
| I2319284 | Certificate of Analysis | Sep 01, 2023 | D113483 |
| D2315105 | Certificate of Analysis | Mar 25, 2023 | D113483 |
| D2315112 | Certificate of Analysis | Mar 25, 2023 | D113483 |
| D2315113 | Certificate of Analysis | Mar 25, 2023 | D113483 |
| D2315117 | Certificate of Analysis | Mar 25, 2023 | D113483 |
| D2315118 | Certificate of Analysis | Mar 25, 2023 | D113483 |
| D2315093 | Certificate of Analysis | Mar 25, 2023 | D113483 |
| D2315079 | Certificate of Analysis | Mar 25, 2023 | D113483 |
| G2308205 | Certificate of Analysis | Mar 25, 2023 | D113483 |
| D2315096 | Certificate of Analysis | Mar 25, 2023 | D113483 |
| H2209304 | Certificate of Analysis | Jun 22, 2022 | D113483 |
| H2209308 | Certificate of Analysis | Jun 22, 2022 | D113483 |
| H2209305 | Certificate of Analysis | Jun 22, 2022 | D113483 |
| H2209303 | Certificate of Analysis | Jun 22, 2022 | D113483 |
| B2225263 | Certificate of Analysis | Jan 11, 2022 | D113483 |
| B2225239 | Certificate of Analysis | Jan 11, 2022 | D113483 |
| B2225122 | Certificate of Analysis | Jan 11, 2022 | D113483 |
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Chemical and Physical Properties
| Solubility | Soluble in organic solvents. Slightly soluble in acidic aqueous solutions. Insoluble in neutral or alkaline solutions. |
|---|---|
| Sensitivity | Light sensitive |
| Melt Point(°C) | 218-220 °C (lit.) |
Safety and Hazards(GHS)
| WGK Germany | 3 |
|---|---|
| RTECS | SF8427000 |
| Reaxy-Rn | 261048 |
Related Documents
Citations of This Product
| 1. Yichuan Chen, Wenlong Li, Yan Yang, Ruitong Zhong, Huiyan Hu, Chunxia Huang, Jing Chen, Lijuan Liang, Yunjun Liu. (2023) Significant increase of anticancer efficacy in vitro and in vivo of liposome entrapped ruthenium(II) polypyridyl complexes. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 257 (115541). [PMID:37295162] [10.1016/j.ejmech.2023.115541] |
| 2. Haisu Wu, Tifang Miao, Qinghua Deng, Li Qian, Haixia Shi, Yun Xu, Xianliang Fu. (2022) Unraveling Electron Structure and Reaction Mechanisms of Functionalized Nickel-Based Complexes for Efficient Hydrogen Evolution. Journal of Physical Chemistry C, 126 (4): (1857–1871). [PMID:] [10.1021/acs.jpcc.1c09956] |
References
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| 2. L de Meis,M M Sorenson. (1989-09-18) ATP regulation of calcium transport in back-inhibited sarcoplasmic reticulum vesicles.. Biochimica et biophysica acta, 984 ((3)): (373-378). [PMID:2528377] |
| 3. R Shiman,T Xia,M A Hill,D W Gray. (1994-10-07) Regulation of rat liver phenylalanine hydroxylase. II. Substrate binding and the role of activation in the control of enzymatic activity.. The Journal of biological chemistry, 269 ((40)): (24647-24656). [PMID:7929136] |
| 4. S S Hassan,N M Rizk. (1997-08-01) Miniaturized graphite sensors doped with metal-bathophenanthroline complexes for the selective potentiometric determination of uric acid in biological fluids.. The Analyst, 122 ((8)): (815-819). [PMID:9338988] |
| 5. A K Malik,A K Malik. (2000-09-20) Determination of the fungicide ferbam in wheat grains after adsorption onto microcrystalline naphthalene.. Journal of AOAC International, 83 ((4)): (971-975). [PMID:10995124] |
| 6. A K Malik,A L Rao. (2000-09-20) Spectrophotometric determination of ferbam [iron(III) dimethyl dithiocarbamate] in commercial sample and wheat grains after extraction of its bathophenanthroline tetraphenylborate complex into molten naphthalene.. Journal of agricultural and food chemistry, 48 ((9)): (4044-4047). [PMID:10995311] |
| 7. Sandrine Ollagnier-de Choudens,Laurence Nachin,Yiannis Sanakis,Laurent Loiseau,Frederic Barras,Marc Fontecave. (2003-03-15) SufA from Erwinia chrysanthemi. Characterization of a scaffold protein required for iron-sulfur cluster assembly.. The Journal of biological chemistry, 278 ((20)): (17993-18001). [PMID:12637501] |
| 8. Katja Witzel,Giridara-Kumar Surabhi,Gottimukkala Jyothsnakumari,Chinta Sudhakar,Andrea Matros,Hans-Peter Mock. (2007-04-10) Quantitative proteome analysis of barley seeds using ruthenium(II)-tris-(bathophenanthroline-disulphonate) staining.. Journal of proteome research, 6 ((4)): (1325-1333). [PMID:17417914] |
| 9. David Plouffe,Achim Brinker,Case McNamara,Kerstin Henson,Nobutaka Kato,Kelli Kuhen,Advait Nagle,Francisco Adrián,Jason T Matzen,Paul Anderson,Tae-Gyu Nam,Nathanael S Gray,Arnab Chatterjee,Jeff Janes,S Frank Yan,Richard Trager,Jeremy S Caldwell,Peter G Schultz,Yingyao Zhou,Elizabeth A Winzeler. (2008-06-27) In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen.. Proceedings of the National Academy of Sciences of the United States of America, 105 ((26)): (9059-9064). [PMID:18579783] |
| 10. Jessica Ihrig,Anja Hausmann,Anika Hain,Nadine Richter,Iqbal Hamza,Roland Lill,Ulrich Mühlenhoff. (2009-12-17) Iron regulation through the back door: iron-dependent metabolite levels contribute to transcriptional adaptation to iron deprivation in Saccharomyces cerevisiae.. Eukaryotic cell, 9 ((3)): (460-471). [PMID:20008079] |
| 11. Roman Buchtík,Zdeněk Trávníček,Ján Vančo,Radovan Herchel,Zdeněk Dvořák. (2011-08-16) Synthesis, characterization, DNA interaction and cleavage, and in vitro cytotoxicity of copper(II) mixed-ligand complexes with 2-phenyl-3-hydroxy-4(1H)-quinolinone.. Dalton transactions (Cambridge, England : 2003), 40 ((37)): (9404-9412). [PMID:21842058] |
| 12. Nur Fadilah Jamaludin,Natalia Yantara,Yan Fong Ng,Mingjie Li,Teck Wee Goh,Krishnamoorthy Thirumal,Tze Chien Sum,Nripan Mathews,Cesare Soci,Subodh Mhaisalkar. (2018-01-04) Grain Size Modulation and Interfacial Engineering of CH3 NH3 PbBr3 Emitter Films through Incorporation of Tetraethylammonium Bromide.. Chemphyschem : a European journal of chemical physics and physical chemistry, 19 ((9)): (1075-1080). [PMID:29297203] |
| 13. S Passarella,E Marra,A Atlante,M Barile,S Doonan,E Quagliariello. (1990-03-01) Uptake of aspartate aminotransferase into mitochondria in vitro causes efflux of malate dehydrogenase and vice versa.. Biochimica et biophysica acta, 1022 ((3)): (273-282). [PMID:2180483] |
| 14. D Zhang,S Okada,T Kawabata,T Yasuda. (1995-03-01) An improved simple colorimetric method for quantitation of non-transferrin-bound iron in serum.. Biochemistry and molecular biology international, 35 ((3)): (635-641). [PMID:7773198] |
| 15. P S DiStefano,D M Chelsea,C M Schick,J F McKelvy. (1993-06-01) Involvement of a metalloprotease in low-affinity nerve growth factor receptor truncation: inhibition of truncation in vitro and in vivo.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 13 ((6)): (2405-2414). [PMID:8501514] |
| 16. Mudasir,N Yoshioka,H Inoue. (2000-01-22) DNA binding of iron(II) mixed-ligand complexes containing 1,10-phenanthroline and 4,7-diphenyl-1,10-phenanthroline.. Journal of inorganic biochemistry, 77 ((3-4)): (239-247). [PMID:10643662] |
| 17. Vladimir K Vanag,Irving R Epstein. (2003-12-03) From the Cover: Segmented spiral waves in a reaction-diffusion system.. Proceedings of the National Academy of Sciences of the United States of America, 100 ((25)): (14635-14638). [PMID:14645709] |
| 18. Martin A Grundy,Nadia Gorman,Peter R Sinclair,Michael J Chorney,Glenn S Gerhard. (2004-05-28) High-throughput non-heme iron assay for animal tissues.. Journal of biochemical and biophysical methods, 59 ((2)): (195-200). [PMID:15163531] |
| 19. Nicole R Buan,Sang-Jin Suh,Jorge C Escalante-Semerena. (2004-08-20) The eutT gene of Salmonella enterica Encodes an oxygen-labile, metal-containing ATP:corrinoid adenosyltransferase enzyme.. Journal of bacteriology, 186 ((17)): (5708-5714). [PMID:15317775] |
| 20. Regis Caspar,Christine Cordier,Jenny B Waern,Carine Guyard-Duhayon,Michel Gruselle,Pascal Le Floch,Hani Amouri. (2006-05-09) A new family of mono- and dicarboxylic ruthenium complexes [Ru(DIP)2(L2)]2+ (DIP = 4,7-diphenyl-1,10-phenanthroline): synthesis, solution behavior, and X-ray molecular structure of trans-[Ru(DIP)2(MeOH)2][OTf]2.. Inorganic chemistry, 45 ((10)): (4071-4078). [PMID:16676968] |
| 21. Sabine Molik,Roland Lill,Ulrich Mühlenhoff. (2007-04-21) Methods for studying iron metabolism in yeast mitochondria.. Methods in cell biology, 80 (261-280). [PMID:17445699] |
| 22. Jinshan Gao,David J Borton,Benjamin C Owen,Zhicheng Jin,Matt Hurt,Lucas M Amundson,Jeremy T Madden,Kuangnan Qian,Hilkka I Kenttämaa. (2011-04-08) Laser-induced acoustic desorption/atmospheric pressure chemical ionization mass spectrometry.. Journal of the American Society for Mass Spectrometry, 22 ((3)): (531-538). [PMID:21472571] |
| 23. H Maazi,S Shirinbak,N Bloksma,M C Nawijn,A J M van Oosterhout. (2011-09-14) Iron administration reduces airway hyperreactivity and eosinophilia in a mouse model of allergic asthma.. Clinical and experimental immunology, 166 ((1)): (80-86). [PMID:21910724] |
| 24. Yichuan Chen, Wenlong Li, Yan Yang, Ruitong Zhong, Huiyan Hu, Chunxia Huang, Jing Chen, Lijuan Liang, Yunjun Liu. (2023) Significant increase of anticancer efficacy in vitro and in vivo of liposome entrapped ruthenium(II) polypyridyl complexes. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 257 (115541). [PMID:37295162] [10.1016/j.ejmech.2023.115541] |
| 25. Haisu Wu, Tifang Miao, Qinghua Deng, Li Qian, Haixia Shi, Yun Xu, Xianliang Fu. (2022) Unraveling Electron Structure and Reaction Mechanisms of Functionalized Nickel-Based Complexes for Efficient Hydrogen Evolution. Journal of Physical Chemistry C, 126 (4): (1857–1871). [PMID:] [10.1021/acs.jpcc.1c09956] |