Batimastat is a potent, broad spectrum matrix metalloprotease (MMP) inhibitor. Batimastat is hydroxamate-type inhibitor of matrix metalloproteinases (MMP).It inhibits the growth and spread of lung tumors,breast cancer regrowth and human colon tumor growth
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Action Type
INHIBITOR
Mechanism of action
Inhibitor of MMP1;Inhibitor of MMP13;Inhibitor of MMP3
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
Batimastat is a potent broad spectrum MMP inhibitor with IC50 of 3, 4, 4, 6, and 20 nM for MMP-1, MMP-2, MMP-9, MMP-7 and MMP-3, respectively. Batimastat was used to study the role of MMP in proteolytic release of EGF in human follicular thyroid carcinoma cell line FTC-133.
Associated Targets(Human)
FCER2TchemLow affinity immunoglobulin epsilon Fc receptor (2 Activities)
1.Zhao Qu, Yushan Lin, Daniel Kam-Wah Mok, Qingya Bian, William Chi-Shing Tai, Sibao Chen. (2020) Arnicolide D Inhibits Triple Negative Breast Cancer Cell Proliferation by Suppression of Akt/mTOR and STAT3 Signaling Pathways. International Journal of Medical Sciences, 17 (11):( 1482–1490). [PMID:32669950]
References
1.Wojtowicz-Praga S, Low J, Marshall J, Ness E, Dickson R, Barter J, Sale M, McCann P, Moore J, Cole A et al.. (1996) Phase I trial of a novel matrix metalloproteinase inhibitor batimastat (BB-94) in patients with advanced cancer.. Invest New Drugs, 14 (2):(193-202). [PMID:8913840]
2.Parsons SL, Watson SA, Steele RJ. (1997) Phase I/II trial of batimastat, a matrix metalloproteinase inhibitor, in patients with malignant ascites.. Eur J Surg Oncol, 23 (6):(526-31). [PMID:9484924]
3.Beattie GJ, Smyth JF. (1998) Phase I study of intraperitoneal metalloproteinase inhibitor BB94 in patients with malignant ascites.. Clin Cancer Res, 4 (8):(1899-902). [PMID:9717817]
4.Oda SK et al.. (2020) A Fas-4-1BB fusion protein converts a death to a pro-survival signal and enhances T cell therapy.. J Exp Med, 217 (12):[PMID:32860705]
5.Paschkowsky S et al.. (2016) Alternative Processing of the Amyloid Precursor Protein Family by Rhomboid Protease RHBDL4.. J Biol Chem, 291 (42):(21903-21912). [PMID:27563067]
6.McColl R et al.. (2016) Analysis and quantification of in vitro myoblast fusion using the LADD Multiple Stain.. Biotechniques, 61 (6):(323-326). [PMID:27938324]
7.Cremasco V et al.. (2014) B cell homeostasis and follicle confines are governed by fibroblastic reticular cells.. Nat Immunol, 15 (10):(973-81). [PMID:25151489]
8.Beltramo E et al.. (2014) Extracellular vesicles derived from mesenchymal stem cells induce features of diabetic retinopathy in vitro.. Acta Diabetol, 51 (6):(1055-64). [PMID:25374383]
9.Keppie SJ et al.. (2021) Matrix-Bound Growth Factors are Released upon Cartilage Compression by an Aggrecan-Dependent Sodium Flux that is Lost in Osteoarthritis.. Function (Oxf), 2 (5):(zqab037). [PMID:34423304]
10.Ambite I et al.. (2016) Molecular Basis of Acute Cystitis Reveals Susceptibility Genes and Immunotherapeutic Targets.. PLoS Pathog, 12 (10):(e1005848). [PMID:27732661]
11.Zhao Qu, Yushan Lin, Daniel Kam-Wah Mok, Qingya Bian, William Chi-Shing Tai, Sibao Chen. (2020) Arnicolide D Inhibits Triple Negative Breast Cancer Cell Proliferation by Suppression of Akt/mTOR and STAT3 Signaling Pathways. International Journal of Medical Sciences, 17 (11):( 1482–1490). [PMID:32669950]
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B2317342