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Batimastat - ≥98%, high purity , CAS No.130370-60-4, Inhibitor of MMP1;Inhibitor of MMP13;Inhibitor of MMP3

Specifications & Purity: ≥98%

CAS#: 130370-60-4
Formula: C₂₃H₃₁N₃O₄S₂
Molecular Weight: 477.64
MDL number: MFCD00866533
PubChem CID: 5362422

Item Number

B125646

Grouped product items
SKU	Size	Availability	Price
B125646-1mg	1mg	In stock	$33.90
B125646-5mg	5mg	In stock	$137.90
B125646-25mg	25mg	In stock	$434.90

Potent, broad-spectrum MMP inhibitor

View related series

MMP1 Inhibitor MMP13 Inhibitor MMP3 Inhibitor

Basic Description

Synonyms	batimastat\|130370-60-4\|BB-94\|Batimastat (BB-94)\|BB94\|BB 94\|Batimastat (MMP Inhibitor)\|Batimastat(BB-94)\|Butanediamide, N4-hydroxy-N1-[(1S)-2-(methylamino)-2-oxo-1-(phenylmethyl)ethyl]-2-(2-methylpropyl)-3-[(2-thienylthio)methyl]-, (2R,3S)-\|CHEMBL279786\|(2
Specifications & Purity	≥98%
Storage Temp	Store at -20°C
Shipped In	Dry ice
Action Type	INHIBITOR
Mechanism of action	Inhibitor of MMP1;Inhibitor of MMP13;Inhibitor of MMP3

Associated Targets

FCER2 Tchem Low affinity immunoglobulin epsilon Fc receptor 0 Activities

Discover Target: FCER2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MMP1 Tchem Interstitial collagenase 0 Activities

Discover Target: MMP1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MMP7 Tchem Matrilysin 0 Activities

Discover Target: MMP7

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MMP13 Tchem Collagenase 3 0 Activities

Discover Target: MMP13

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MMP14 Tchem Matrix metalloproteinase-14 0 Activities

Discover Target: MMP14

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MMP9 Tchem Matrix metalloproteinase-9 0 Activities

Discover Target: MMP9

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MMP2 Tchem 72 kDa type IV collagenase 0 Activities

Discover Target: MMP2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADAM17 Tchem Disintegrin and metalloproteinase domain-containing protein 17 0 Activities

Discover Target: ADAM17

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MMP3 Tchem Stromelysin-1 0 Activities

Discover Target: MMP3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

Pubchem Sid	488195427
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488195427
IUPAC Name	(2S,3R)-N-hydroxy-N'-[(2S)-1-(methylamino)-1-oxo-3-phenylpropan-2-yl]-3-(2-methylpropyl)-2-(thiophen-2-ylsulfanylmethyl)butanediamide
INCHI	InChI=1S/C23H31N3O4S2/c1-15(2)12-17(18(22(28)26-30)14-32-20-10-7-11-31-20)21(27)25-19(23(29)24-3)13-16-8-5-4-6-9-16/h4-11,15,17-19,30H,12-14H2,1-3H3,(H,24,29)(H,25,27)(H,26,28)/t17-,18+,19+/m1/s1
InChi Key	XFILPEOLDIKJHX-QYZOEREBSA-N
Canonical SMILES	CC(C)CC(C(CSC1=CC=CS1)C(=O)NO)C(=O)NC(CC2=CC=CC=C2)C(=O)NC
Isomeric SMILES	CC(C)C[C@H]([C@H](CSC1=CC=CS1)C(=O)NO)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)NC
WGK Germany	3
PubChem CID	5362422
Molecular Weight	477.64

CAS Registry No.

DrugBank Ligand

PubChem CID

Wikipedia

ChEMBL Ligand

RCSB PDB Ligand

PubChem SID

Certificates

Certificate of Analysis(COA)

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7 results found

Lot Number	Certificate Type	Date	Item
K1813128	Certificate of Analysis	Apr 02, 2024	B125646
B2317336	Certificate of Analysis	Jan 06, 2023	B125646
B2317341	Certificate of Analysis	Jan 06, 2023	B125646
B2317342	Certificate of Analysis	Jan 06, 2023	B125646
B2317366	Certificate of Analysis	Jan 06, 2023	B125646
B2317376	Certificate of Analysis	Jan 06, 2023	B125646
K1813127	Certificate of Analysis	Jul 18, 2022	B125646

Pictogram(s)

GHS07

Signal

Warning

Hazard Statements

H315,H319,H335

Precautionary Statements

P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P304+P340,P403+P233,P362+P364,P264+P265,P337+P317,P332+P317,P319

WGK Germany

References

1. Wojtowicz-Praga S, Low J, Marshall J, Ness E, Dickson R, Barter J, Sale M, McCann P, Moore J, Cole A et al.. (1996) Phase I trial of a novel matrix metalloproteinase inhibitor batimastat (BB-94) in patients with advanced cancer.. Invest New Drugs, 14 (2): (193-202). [PMID:8913840]
2. Parsons SL, Watson SA, Steele RJ. (1997) Phase I/II trial of batimastat, a matrix metalloproteinase inhibitor, in patients with malignant ascites.. Eur J Surg Oncol, 23 (6): (526-31). [PMID:9484924]
3. Beattie GJ, Smyth JF. (1998) Phase I study of intraperitoneal metalloproteinase inhibitor BB94 in patients with malignant ascites.. Clin Cancer Res, 4 (8): (1899-902). [PMID:9717817]
4. Oda SK et al.. (2020) A Fas-4-1BB fusion protein converts a death to a pro-survival signal and enhances T cell therapy.. J Exp Med, 217 (12): [PMID:32860705]
5. Paschkowsky S et al.. (2016) Alternative Processing of the Amyloid Precursor Protein Family by Rhomboid Protease RHBDL4.. J Biol Chem, 291 (42): (21903-21912). [PMID:27563067]
6. McColl R et al.. (2016) Analysis and quantification of in vitro myoblast fusion using the LADD Multiple Stain.. Biotechniques, 61 (6): (323-326). [PMID:27938324]
7. Cremasco V et al.. (2014) B cell homeostasis and follicle confines are governed by fibroblastic reticular cells.. Nat Immunol, 15 (10): (973-81). [PMID:25151489]
8. Beltramo E et al.. (2014) Extracellular vesicles derived from mesenchymal stem cells induce features of diabetic retinopathy in vitro.. Acta Diabetol, 51 (6): (1055-64). [PMID:25374383]
9. Ambite I et al.. (2016) Molecular Basis of Acute Cystitis Reveals Susceptibility Genes and Immunotherapeutic Targets.. PLoS Pathog, 12 (10): (e1005848). [PMID:27732661]
10. Keppie SJ et al.. (2021) Matrix-Bound Growth Factors are Released upon Cartilage Compression by an Aggrecan-Dependent Sodium Flux that is Lost in Osteoarthritis.. Function (Oxf), 2 (5): (zqab037). [PMID:34423304]

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