Batimastat is a potent, broad spectrum matrix metalloprotease (MMP) inhibitor. Batimastat is hydroxamate-type inhibitor of matrix metalloproteinases (MMP).It inhibits the growth and spread of lung tumors,breast cancer regrowth and human colon tumor growth
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Action Type
INHIBITOR
Mechanism of action
Inhibitor of MMP1;Inhibitor of MMP13;Inhibitor of MMP3
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
Batimastat is a potent broad spectrum MMP inhibitor with IC50 of 3, 4, 4, 6, and 20 nM for MMP-1, MMP-2, MMP-9, MMP-7 and MMP-3, respectively. Batimastat was used to study the role of MMP in proteolytic release of EGF in human follicular thyroid carcinoma cell line FTC-133.
Associated Targets(Human)
FCER2TchemLow affinity immunoglobulin epsilon Fc receptor (2 Activities)
1.Wojtowicz-Praga S, Low J, Marshall J, Ness E, Dickson R, Barter J, Sale M, McCann P, Moore J, Cole A et al.. (1996) Phase I trial of a novel matrix metalloproteinase inhibitor batimastat (BB-94) in patients with advanced cancer.. Invest New Drugs, 14 (2):(193-202). [PMID:8913840]
2.Parsons SL, Watson SA, Steele RJ. (1997) Phase I/II trial of batimastat, a matrix metalloproteinase inhibitor, in patients with malignant ascites.. Eur J Surg Oncol, 23 (6):(526-31). [PMID:9484924]
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K1813128