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Bax channel blocker - 10mM in DMSO, high purity , CAS No.335165-68-9
a potent inhibitor of Bax-mediated mitochondrial cytochrome c release
Basic Description Synonyms J-019229 | NCGC00092317-01 | 3,6-DIBROMO-ALPHA-(1-PIPERAZINYLMETHYL)-9H-CARBAZOLE-9-ETHANOL DIHYDROCHLORIDE | 1-(3,6-dibromo-9H-carbazol-9-yl)-3-(piperazin-1-yl)propan-2-ol dihydrochloride | 1-(3,6-dibromo-9-carbazolyl)-3-(1-piperazinyl)-2-propanol | 3,6- Specifications & Purity 10mM in DMSO Storage Temp Store at -80°C Shipped In Ice chest + Ice pads Product Description Bax channel blocker is a potent inhibitor of Bax-mediated mitochondrial cytochrome C release (IC|50|= 0.52 μM). Suggested to inhibit Bax channel formation/activity.
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name 1-(3,6-dibromocarbazol-9-yl)-3-piperazin-1-ylpropan-2-ol;dihydrochloride INCHI InChI=1S/C19H21Br2N3O.2ClH/c20-13-1-3-18-16(9-13)17-10-14(21)2-4-19(17)24(18)12-15(25)11-23-7-5-22-6-8-23;;/h1-4,9-10,15,22,25H,5-8,11-12H2;2*1H InChi Key HWFKCAFKXZFOQT-UHFFFAOYSA-N Canonical SMILES C1CN(CCN1)CC(CN2C3=C(C=C(C=C3)Br)C4=C2C=CC(=C4)Br)O.Cl.Cl Isomeric SMILES C1CN(CCN1)CC(CN2C3=C(C=C(C=C3)Br)C4=C2C=CC(=C4)Br)O.Cl.Cl PubChem CID 2729026 Molecular Weight 467.20
Chemical and Physical Properties Refractive Index n20D~1.71 (Predicted)
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