BAY 11-7082 - ≥98%, high purity , CAS No.19542-67-7

Item Number

B129693

• Synonyms: 7-Chloro-1-cyclopropylmethyl-5-phenyl-1H-1,4-benzodiazepin-2(3H)-one | CHEBI:92270 | Cyanovinyl)-p-tolylsulfone, beta-( | J-501956 | UNII-4Y5G2A4F6O | Curator_000002 | HMS3678M15 | (2E)-3-(4-methylbenzenesulfonyl)prop-2-enenitrile | NCGC00025272-03 | NCGC
• Specifications & Purity: Moligand™, ≥98%
• Biochemical and Physiological Mechanisms: BAY 11-7082, a potential anti-inflammatory agent, is an irreversible inhibitor of IKK α and phosphorylation of cytokine-inducible IκBα (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-α, NFKBIA; IC50=10 μM). In intact HUVECs,
• Storage Temp: Store at 2-8°C,Argon charged
• Shipped In: Wet ice
• Grade: Moligand™
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

BAY 11-7082 is a NF-κB inhibitor, inhibits TNFα-induced IκBα phosphorylation with IC50 of 10 μM. Also inhibiting components of the ubiquitin system.
An anti-inflammatory agent and NFκB inhibitor