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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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B607946-1mg | 1mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $127.90 | |
B607946-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $260.90 | |
B607946-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $486.90 | |
B607946-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $906.90 |
Synonyms | BAY545;compound 8 |
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Specifications & Purity | Moligand™, ≥98% |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | ANTAGONIST |
Mechanism of action | Antagonist of A 2B receptor |
Product Description | BAY-545 is a potent and selective A2B adenosine receptor antagonist, with an IC50 of 59 nM. BAY-545 also exhibits IC50s of 66, 400, 280 nM for human, mouse, rat A2B adenosine receptor in cells, respectively, and a Ki of 97 nM for human A2B adenosine receptor, with more selectivity over A1, A2A, and A3 adenosine receptor. |
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IUPAC Name | 3-ethyl-6-(4-hydroxypiperidine-1-carbonyl)-5-methyl-1-(3,3,3-trifluoropropyl)thieno[2,3-d]pyrimidine-2,4-dione |
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INCHI | InChI=1S/C18H22F3N3O4S/c1-3-23-14(26)12-10(2)13(15(27)22-7-4-11(25)5-8-22)29-16(12)24(17(23)28)9-6-18(19,20)21/h11,25H,3-9H2,1-2H3 |
InChi Key | NTYVAKNEYLJAPT-UHFFFAOYSA-N |
Canonical SMILES | CCN1C(=O)C2=C(N(C1=O)CCC(F)(F)F)SC(=C2C)C(=O)N3CCC(CC3)O |
Isomeric SMILES | CCN1C(=O)C2=C(N(C1=O)CCC(F)(F)F)SC(=C2C)C(=O)N3CCC(CC3)O |
PubChem CID | 118016229 |
Molecular Weight | 433.45 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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G2423174 | Certificate of Analysis | Apr 19, 2024 | B607946 |
G2423188 | Certificate of Analysis | Apr 19, 2024 | B607946 |
G2423189 | Certificate of Analysis | Apr 19, 2024 | B607946 |
G2423191 | Certificate of Analysis | Apr 19, 2024 | B607946 |
G2423192 | Certificate of Analysis | Apr 19, 2024 | B607946 |
G2423194 | Certificate of Analysis | Apr 19, 2024 | B607946 |
G2423195 | Certificate of Analysis | Apr 19, 2024 | B607946 |
G2423197 | Certificate of Analysis | Apr 19, 2024 | B607946 |
1. Härter M, Kalthof B, Delbeck M, Lustig K, Gerisch M, Schulz S, Kast R, Meibom D, Lindner N. (2019) Novel non-xanthine antagonist of the A2B adenosine receptor: From HTS hit to lead structure.. Eur J Med Chem, 163 (13): (763-778). [PMID:30576906] [10.1021/op500134e] |