BAY 60-7550|439083-90-6|BAY-60-7550|Bay60-7550|BAY-607550|2-[(3,4-dimethoxyphenyl)methyl]-7-[(2R,3R)-2-hydroxy-6-phenylhexan-3-yl]-5-methyl-1H-imidazo[5,1-f][1,2,4]triazin-4-one|ZRN7LZK9TQ|CHEMBL370962|Imidazo(5,1-f)(1,2,4)triazin-4(1H)-one, 2-((3,4-dimet
Specifications & Purity
Moligand™, ≥95%
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Action Type
INHIBITOR
Mechanism of action
Inhibitor of phosphodiesterase 2A
Product Description
BAY-60-7550 is a potent PDE2 inhibitor with IC|50|values of 2.0 nM (bovine) and 4.7 nM (human). It is 50-fold more selective for PDE2 compared to PDE1 and greater than 100-fold selective compared to PDE5 PDE3B, PDE4B, PDE7B, PDE8A, PDE9A, PDE10A, and PDE11A. At 3 mg/kg BAY-60-7550 antagonizes oxidative stress-induced anxiety-like behavioral effects in mice by increasing cGMP signaling. At 1 mg/kg BAY-60-7550 improves the performance of rats in an object location task, enhancing cAMP/cGMP-mediated object and spatial memory consolidation. cAMP and cGMP are important mediators of signal transduction and hence a wide range of cellular processes including synaptic plasticity and vasodilation. Type 2 cyclic nucleotide phosphodiesterases (PDE2) isoforms inactivate cAMP and cGMP by hydrolyzing the phosphodiester bond.
Product Properties
pKa
pKa: 3.37 (Predicted), pKa: 7.9 (Predicted)
Associated Targets
ABCB1Tchem Multidrug resistance protein 1 0 Activities