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Bay 61-3606 hydrochloride - ≥98%, high purity , CAS No.732983-37-8

Item Number
B275245
Grouped product items
SKUSizeAvailabilityPrice Qty
B275245-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$128.90
B275245-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$494.90
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Potent, selective, cell-permeable Syk kinase inhibitor

Basic Description

Specifications & Purity≥98%
Storage TempStore at -20°C,Desiccated
Shipped InIce chest + Ice pads
GradeMoligand™
Product Description

Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.

Product Properties

Ki DataSyk tyrosine kinase activity: Ki= 7.5 nM

Associated Targets(Human)

CDC7 Tchem Cell division cycle 7-related protein kinase (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CHUK Tchem Inhibitor of nuclear factor kappa-B kinase subunit alpha (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
SYK Tclin Tyrosine-protein kinase SYK (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
MAP4K2 Tchem Mitogen-activated protein kinase kinase kinase kinase 2 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
NEK4 Tchem Serine/threonine-protein kinase Nek4 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CLK4 Tchem Dual specificity protein kinase CLK4 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GSK3B Tclin Glycogen synthase kinase-3 beta (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 2-[[7-(3,4-dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]pyridine-3-carboxamide
INCHI InChI=1S/C20H18N6O3/c1-28-15-6-5-12(10-16(15)29-2)14-11-17-22-8-9-26(17)20(24-14)25-19-13(18(21)27)4-3-7-23-19/h3-11H,1-2H3,(H2,21,27)(H,23,24,25)
InChi Key JWQOJVOKBAAAAR-UHFFFAOYSA-N
Canonical SMILES COC1=C(C=C(C=C1)C2=CC3=NC=CN3C(=N2)NC4=C(C=CC=N4)C(=O)N)OC
Isomeric SMILES COC1=C(C=C(C=C1)C2=CC3=NC=CN3C(=N2)NC4=C(C=CC=N4)C(=O)N)OC
Alternate CAS 732983-37-8
PubChem CID 10200390
MeSH Entry Terms 2-(7-(3,4-dimethoxyphenyl)imidazo(1,2-c)pyrimidin-5-ylamino)nicotinamide;BAY 61-3606;BAY-61-3606;BAY61-3606
Molecular Weight 390.40

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

SolubilitySoluble in water to 50 mM and in DMSO to 5 mM

Related Documents

 SDS

 Specification Sheet

References

1. Hu W et al..  (2019)  Down-Regulation of Mir-107 Worsen Spatial Memory by Suppressing SYK Expression and Inactivating NF-?B Signaling Pathway..  Curr Alzheimer Res,  16  (2): (135-145).  [PMID:30543171]

Solution Calculators

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