The store will not work correctly when cookies are disabled.
Bay 61-3606 hydrochloride - ≥98%, high purity , CAS No.732983-37-8
Potent, selective, cell-permeable Syk kinase inhibitor
Basic Description
| Synonyms | 2-[[7-(3,4-Dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]pyridine-3-carboxamidehydrochloride |
|---|
| Specifications & Purity | ≥98% |
|---|
| Storage Temp | Store at -20°C,Desiccated |
|---|
| Shipped In | Dry ice |
|---|
| Grade | Moligand™ |
|---|
| Product Description | Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. |
|---|
Product Properties
| Ki Data | Syk tyrosine kinase activity: Ki= 7.5 nM |
|---|
Names and Identifiers
| IUPAC Name | 2-[[7-(3,4-dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]pyridine-3-carboxamide |
|---|
| INCHI | InChI=1S/C20H18N6O3/c1-28-15-6-5-12(10-16(15)29-2)14-11-17-22-8-9-26(17)20(24-14)25-19-13(18(21)27)4-3-7-23-19/h3-11H,1-2H3,(H2,21,27)(H,23,24,25) |
|---|
| InChi Key | JWQOJVOKBAAAAR-UHFFFAOYSA-N |
|---|
| Canonical SMILES | COC1=C(C=C(C=C1)C2=CC3=NC=CN3C(=N2)NC4=C(C=CC=N4)C(=O)N)OC |
|---|
| Isomeric SMILES | COC1=C(C=C(C=C1)C2=CC3=NC=CN3C(=N2)NC4=C(C=CC=N4)C(=O)N)OC |
|---|
| Alternate CAS | 732983-37-8 |
|---|
| PubChem CID | 10200390 |
|---|
| MeSH Entry Terms | 2-(7-(3,4-dimethoxyphenyl)imidazo(1,2-c)pyrimidin-5-ylamino)nicotinamide;BAY 61-3606;BAY-61-3606;BAY61-3606 |
|---|
| Molecular Weight | 390.40 |
|---|
Chemical and Physical Properties
| Solubility | Soluble in water to 50 mM and in DMSO to 5 mM |
|---|
References
| 1. Hu W et al.. (2019) Down-Regulation of Mir-107 Worsen Spatial Memory by Suppressing SYK Expression and Inactivating NF-?B Signaling Pathway.. Curr Alzheimer Res, 16 (2): (135-145). [PMID:30543171] |
Solution Calculators
Molarity Calculator
Determine the necessary mass, volume, or concentration for preparing a solution.
Dilution Calculator
Determine the dilution needed to prepare a stock solution.
Reconstitution Calculator
