Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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B287148-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $68.90 | |
B287148-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $256.90 |
Potent and selective cell-permeable human neutrophil elastase (HNE) inhibitor
Synonyms | MS-26790 | 5-((4R)-5-Acetyl-1,2,3,4-tetrahydro-6-methyl-2-oxo-1-(3-(trifluoromethyl)phenyl)-4-pyrimidinyl)-2-pyridinecarbonitrile | (R)-5-(5-Acetyl-6-methyl-2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydropyrimidin-4-yl)picolinonitrile | BB163664 | |
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Specifications & Purity | ≥98%(HPLC) |
Biochemical and Physiological Mechanisms | Potent and selective cell-permeable human neutrophil elastase (HNE) inhibitor (IC50= 20 nM). Exhibits around 2000-fold selectivity for NHE against a panel of 21 other serine proteases. Effective in an acute lung injury modelin vivo. Orally bioavailable. I |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
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IUPAC Name | 5-[(6R)-5-acetyl-4-methyl-2-oxo-3-[3-(trifluoromethyl)phenyl]-1,6-dihydropyrimidin-6-yl]pyridine-2-carbonitrile |
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INCHI | InChI=1S/C20H15F3N4O2/c1-11-17(12(2)28)18(13-6-7-15(9-24)25-10-13)26-19(29)27(11)16-5-3-4-14(8-16)20(21,22)23/h3-8,10,18H,1-2H3,(H,26,29)/t18-/m1/s1 |
InChi Key | PGIVGIFOWOVINL-GOSISDBHSA-N |
Canonical SMILES | CC1=C(C(NC(=O)N1C2=CC=CC(=C2)C(F)(F)F)C3=CN=C(C=C3)C#N)C(=O)C |
Isomeric SMILES | CC1=C([C@H](NC(=O)N1C2=CC=CC(=C2)C(F)(F)F)C3=CN=C(C=C3)C#N)C(=O)C |
PubChem CID | 23728722 |
Molecular Weight | 400.35 |
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Solubility | Solvent:DMSO, Max Conc. mg/mL: 40.03, Max Conc. mM: 100 |
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