BAY 707 - ≥98%(HPLC), high purity , CAS No.2109805-96-9

Item Number

B286864

• Synonyms: N-Ethyl-4-[(3S)-3-methyl-4-morpholinyl]-1H-pyrrolo[2,3-b]pyridine-2-carboxamide;(S)-N-Ethyl-4-(3-methylmorpholino)-1H-pyrrolo[2,3-b]pyridine-2-carboxamide
• Specifications & Purity: ≥98%(HPLC)
• Biochemical and Physiological Mechanisms: Potent and selective MTH1 inhibitor (IC50= 2.3 nM). Exhibits no significant activity at 1 μM concentration against a panel of 97 kinases. Cell-permeable and activein vivo. Displays no antitumor activityin vitroorin vivo.
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads

Product Description

BAY-707 is a substrate-competitive, highly potent and selective inhibitor of MTH1(NUDT1) with an IC50 of 2.3 nM. BAY-707 has a good pharmacokinetic (PK) profile to other MTH1 compounds and is well-tolerated in mice, but shows a clear lack of in vitro or in vivo anticancer efficacy。