Determine the necessary mass, volume, or concentration for preparing a solution.
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SKU | Size | Availability | Price | Qty |
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B288179-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $117.90 | |
B288179-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $454.90 |
Potent Tie2 inhibitor
Specifications & Purity | ≥98%(HPLC) |
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Biochemical and Physiological Mechanisms | Potent Tie 2 inhibitor (IC50= 1.3 nM for autophosphorylation of Tie2 in HUVECs). Selective for Tie2 over other angiogenic receptor tyrosine kinases, including VEGFR, FGFR and PDGFR. Displaysin vivoefficacy in some murine glioma models.Tie2 is also known a |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 3-cyano-N-[2,4-dimethyl-5-(6-pyridin-3-ylimidazo[1,2-b]pyrazol-1-yl)phenyl]-5-(pentafluoro-λ6-sulfanyl)benzamide |
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INCHI | InChI=1S/C26H19F5N6OS/c1-16-8-17(2)24(36-6-7-37-25(36)13-23(35-37)19-4-3-5-33-15-19)12-22(16)34-26(38)20-9-18(14-32)10-21(11-20)39(27,28,29,30)31/h3-13,15H,1-2H3,(H,34,38) |
InChi Key | MPASHPJAIUOWCK-UHFFFAOYSA-N |
Canonical SMILES | CC1=CC(=C(C=C1NC(=O)C2=CC(=CC(=C2)C#N)S(F)(F)(F)(F)F)N3C=CN4C3=CC(=N4)C5=CN=CC=C5)C |
Isomeric SMILES | CC1=CC(=C(C=C1NC(=O)C2=CC(=CC(=C2)C#N)S(F)(F)(F)(F)F)N3C=CN4C3=CC(=N4)C5=CN=CC=C5)C |
PubChem CID | 71623052 |
Molecular Weight | 558.53 |
Enter Lot Number to search for COA:
Solubility | Solvent:DMSO, Max Conc. mg/mL: None, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: None, Max Conc. mM: 100 |
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