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SKU | Size | Availability | Price | Qty |
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B649849-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $110.90 | |
B649849-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $200.90 | |
B649849-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $400.90 | |
B649849-50mg | 50mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $640.90 | |
B649849-100mg | 100mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,050.90 |
Specifications & Purity | ≥99% |
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Biochemical and Physiological Mechanisms | BAY-899 is an orally active and selective luteinizing hormone receptor (LH-R) antagonist with IC 50 s of 185 nM and 46nM for hLH (human LH) and rLH (rat LH), respectively. BAY-899 can reduce sex hormone levels. |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Product Description | BAY-899 is an orally active and selective luteinizing hormone receptor (LH-R) antagonist with IC 50 s of 185 nM and 46nM for hLH (human LH) and rLH (rat LH), respectively. BAY-899 can reduce sex hormone levels In Vivo BAY-899 (oral; 12.5 mg/kg/day; for 8 days) shows an efficiency to reduce serum estradiol levels in intact female rats . BAY-899 (iv of 0.5 mg/kg or po of 2 mg/kg) has a t 1/2 of 11 hours and 12 hours for iv and po. And the C max is 0.97 kg/L and 0.24 kg/L for iv and po . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Intact female rats Dosage: 12.5 mg/kg Administration: Oral; for 8 days Result: Showed an efficiency to reduce serum estradiol levels. Animal Model: Female and male Wistar rats Dosage: 0.5 mg/kg of iv or 2 mg/kg of po Administration: Iv or po Result: Has t 1/2 s of 11 hours and 12 hours for iv and po. And the C max s are 0.97 kg/L and 0.24 kg/L for iv and po. Form:Solid IC50& Target:IC50: 185 nM (hLH) and 46nM (rLH) |
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IUPAC Name | (5S)-N-[2-(4-fluorophenoxy)pyrimidin-5-yl]-5-(4-fluorophenyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carboxamide |
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INCHI | InChI=1S/C25H19F2N5O2/c26-17-5-3-16(4-6-17)23-21-2-1-12-28-22(21)11-13-32(23)25(33)31-19-14-29-24(30-15-19)34-20-9-7-18(27)8-10-20/h1-10,12,14-15,23H,11,13H2,(H,31,33)/t23-/m0/s1 |
InChi Key | VKQBTIMLSDGNLG-QHCPKHFHSA-N |
Canonical SMILES | C1CN(C(C2=C1N=CC=C2)C3=CC=C(C=C3)F)C(=O)NC4=CN=C(N=C4)OC5=CC=C(C=C5)F |
Isomeric SMILES | C1CN([C@H](C2=C1N=CC=C2)C3=CC=C(C=C3)F)C(=O)NC4=CN=C(N=C4)OC5=CC=C(C=C5)F |
PubChem CID | 139600336 |
Molecular Weight | 459.45 |
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Solubility | DMSO : 130 mg/mL (282.95 mM; Need ultrasonic) |
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