BAY-985 - 98%, high purity , CAS No.2409479-29-2, Inhibitor of fms related receptor tyrosine kinase 3;Inhibitor of inhibitor of nuclear factor kappa B kinase subunit epsilon;Inhibitor of ribosomal protein S6 kinase A6;Inhibitor of serine/threonine kinase 17a;Inhibitor of TANK binding kinase 1

Item Number

B414279

• Specifications & Purity: Moligand™, ≥98%
• Biochemical and Physiological Mechanisms: BAY-985 is a potent and highly selective TBK1/IKKε inhibitor. BAY-985 shows high potency toward TBK1 (IC50 = 2 nM, low ATP assay; 30 nM, high ATP assay) and IKKε(IC50 = 2 nM), as well as high potency in the mechanistic pIRF3 assay (IC50 = 74 nM), and an a
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: INHIBITOR
• Mechanism of action: Inhibitor of fms related receptor tyrosine kinase 3;Inhibitor of inhibitor of nuclear factor kappa B kinase subunit epsilon;Inhibitor of ribosomal protein S6 kinase A6;Inhibitor of serine/threonine kinase 17a;Inhibitor of TANK binding kinase 1

Product Description

Information

BAY-985 is a potent and highly selectiveTBK1/IKKεinhibitor. BAY-985 shows high potency towardTBK1(IC50 = 2 nM, low ATP assay; 30 nM, high ATP assay) andIKKε(IC50 = 2 nM), as well as high potency in the mechanistic pIRF3 assay (IC50 = 74 nM), and an antiproliferative effect on SK-MEL-2 cells (IC50 = 900 nM).

Targets

TBK1 (in low ATP assay); IKKε (Cell-free assay); TBK1 (in high ATP assay); pIRF3 (Cell-free assay) 2 nM ;2 nM; 30 nM; 74 nM

In vitro

BAY-985 is a potent and highly selective TBK1/IKKε inhibitor that inhibits the cellular phosphorylation of interferon regulatory factor 3 and displays antiproliferative efficacy in the melanoma cell line SK-MEL-2.

In vivo

BAY-985 shows only weak antitumor activity in the SK-MEL-2 human melanoma xenograft model.

Cell Research(from reference)

Cell lines：ACHN, SK-MEL-2, MDA-MB231 cells 

Concentrations：100 nM 

Incubation Time：96 h