BAY-u 9773 - A solution in ethanol, high purity , CAS No.154978-38-8, Antagonist of CysLT 1 receptor;Agonist of CysLT 2 receptor;Antagonist of CysLT 2 receptor

Item Number

B331357

• Synonyms: Benzoic acid,4-[[(1R,2E,4E,6Z,9Z)-1-[(1S)-4-carboxy-1-hydroxybutyl]-2,4,6,9-pentadecatetraen-1-yl]thio]- | HY-107609 | Benzoic acid, 4-[[(1R,2E,4E,6Z,9Z)-1-[(1S)-4-carboxy-1-hydroxybutyl]-2,4,6,9-pentadecatetraen-1-yl]thio]- | 6-(4'-carboxyphenylthio)-5-h
• Specifications & Purity: Moligand™, A solution in ethanol
• Storage Temp: Store at -80°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: AGONIST, ANTAGONIST
• Mechanism of action: Antagonist of CysLT 1 receptor;Agonist of CysLT 2 receptor;Antagonist of CysLT 2 receptor

Product Description

BAY-u 9773 is a cysteinyl leukotriene receptor antagonist which displays equal affinity towards CysLT|1|and CysLT|2|receptors. This inhibitory action suppresses bronchial and venous muscle contractions in human muscle preparations. Alternate studies demonstrate that BAY-u 9773 inhibits eosinophil infiltration in airway walls. BAY-u 9773 inhibits water up-regulation by aquaporin 4, via antagonism of the CysLT|2|receptor. The permeability of cysteinyl leukotriene receptors across transendothelial membranes is reduced upon addition of BAY-u 9773. Furthermore,this compound acts as a competitive antagonist towards LTC|4|and LTE|4|receptors, which leads to contractions in trachea of guinea pig models.