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(±)-BAYK8644 - ≥98%, high purity , CAS No.71145-03-4, Activator of Ca v1.1;Activator of Ca v1.2;Activator of Ca v1.3;Activator of Ca v1.4

≥98%

CAS#: 71145-03-4
Formula: C₁₆H₁₅F₃N₂O₄
Molecular Weight: 356.3
PubChem CID: 2303

Item Number

B275937

Grouped product items
SKU	Size	Availability	Price
B275937-5mg	5mg	In stock	$98.90
B275937-10mg	10mg	In stock	$157.90
B275937-50mg	50mg	In stock	$513.90
B275937-100mg	100mg	In stock	$820.90

Potent L-type Ca 2+ channel activator

View related series

Cav1.1 Activator Cav1.2 Activator Cav1.3 Activator Cav1.4 Activator

Basic Description

Synonyms	71145-03-4\|Bay K 8644\|(+/-)-BAY K 8644\|methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate\|BAY-K-8644\|BayK8644\|Bay K8644\|BAYK 8644\|(+/-)-Bay K8644\|93468-89-4\|MLS000028858\|3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-d
Specifications & Purity	≥98%
Storage Temp	Store at -20°C,Desiccated
Shipped In	Ice chest + Ice pads
Action Type	ACTIVATOR
Mechanism of action	Activator of Ca v1.1;Activator of Ca v1.2;Activator of Ca v1.3;Activator of Ca v1.4
Product Description	Product Describtion: Bay K 8644, a dihydropyridine compound, is a specific L-type Ca2+ channel agonist. Bay K 8644 increases Ca2+ influx through sarcolemmal Ca2+ channels by increasing the open time of the channel.

Associated Targets

CACNA1C Tclin Voltage-dependent L-type calcium channel subunit alpha-1C 0 Activities

Discover Target: CACNA1C

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CACNA1D Tclin Voltage-dependent L-type calcium channel subunit alpha-1D 0 Activities

Discover Target: CACNA1D

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CACNA1F Tchem Voltage-dependent L-type calcium channel subunit alpha-1F 0 Activities

Discover Target: CACNA1F

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CACNA1S Tclin Voltage-dependent L-type calcium channel subunit alpha-1S 0 Activities

Discover Target: CACNA1S

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate
INCHI	InChI=1S/C16H15F3N2O4/c1-8-12(15(22)25-3)13(14(21(23)24)9(2)20-8)10-6-4-5-7-11(10)16(17,18)19/h4-7,13,20H,1-3H3
InChi Key	ZFLWDHHVRRZMEI-UHFFFAOYSA-N
Canonical SMILES	CC1=C(C(C(=C(N1)C)[N+](=O)[O-])C2=CC=CC=C2C(F)(F)F)C(=O)OC
Isomeric SMILES	CC1=C(C(C(=C(N1)C)[N+](=O)[O-])C2=CC=CC=C2C(F)(F)F)C(=O)OC
PubChem CID	2303
Molecular Weight	356.3

PubChem CID

BindingDB Ligand

CAS Registry No.

Wikipedia

ChEMBL Ligand

Certificates

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4 results found

Lot Number	Certificate Type	Date	Item
F2230058	Certificate of Analysis	Apr 14, 2023	B275937
F2230069	Certificate of Analysis	Apr 14, 2023	B275937
F2230112	Certificate of Analysis	Apr 14, 2023	B275937
F2230113	Certificate of Analysis	Apr 14, 2023	B275937

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation
Precautionary Statements	P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P264:Wash hands [and …] thoroughly after handling. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help.

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