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BC-1215 - 98%, high purity , CAS No.1507370-20-8
Basic Description Synonyms BC-1215 | 1507370-20-8 | N1,N2-Bis(4-(pyridin-2-yl)benzyl)ethane-1,2-diamine | N,N'-Bis[(4-pyridin-2-ylphenyl)methyl]ethane-1,2-diamine | N1,N2-Bis[[4-(2-pyridinyl)phenyl]methyl]- 1,2-ethanediamine | {[4-(PYRIDIN-2-YL)PHENYL]METHYL}[2-({[4-(PYRIDIN-2-YL)PHENYL]METH Specifications & Purity ≥98% Biochemical and Physiological Mechanisms BC-1215 is an inhibitor of F-box protein 3 (Fbxo3, a ubiquitin E3 ligase component) with IC50 of 0.9 μg/mL and LC50 of 87 μg/ml for IL-1β release. BC-1215 inhibits the Fbxo3-TRAF activation pathway by destabilizing TRAF1-6. Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Product Description Information
BC-1215 is an inhibitor of F-box protein 3 (Fbxo3, a ubiquitin E3 ligase component) with IC50 of 0.9 μg/mL and LC50 of 87 μg/ml for IL-1β release. BC-1215 inhibits the Fbxo3-TRAF activation pathway by destabilizing TRAF1-6.
Targets
IL-1β release (Cell-free assay); IL-1β release (Cell-free assay) 0.9 μg/mL; 87 μg/mL(LC50)
Associated Targets(Human) Associated Targets(non-human) Names and Identifiers IUPAC Name N,N'-bis[(4-pyridin-2-ylphenyl)methyl]ethane-1,2-diamine INCHI InChI=1S/C26H26N4/c1-3-15-29-25(5-1)23-11-7-21(8-12-23)19-27-17-18-28-20-22-9-13-24(14-10-22)26-6-2-4-16-30-26/h1-16,27-28H,17-20H2 InChi Key IXEPQJQQSLMESJ-UHFFFAOYSA-N Canonical SMILES C1=CC=NC(=C1)C2=CC=C(C=C2)CNCCNCC3=CC=C(C=C3)C4=CC=CC=N4 Isomeric SMILES C1=CC=NC(=C1)C2=CC=C(C=C2)CNCCNCC3=CC=C(C=C3)C4=CC=CC=N4 WGK Germany 3 PubChem CID 72201045 Molecular Weight 394.51
Chemical and Physical Properties Solubility Solubility (25°C) In vitro DMSO: 79 mg/mL (200.24 mM); Ethanol: 79 mg/mL (200.24 mM); Water: Insoluble;
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H302: Harmful if swallowed
Precautionary Statements P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P301+P317: IF SWALLOWED: Get medical help.
WGK Germany 3 RIDADR NONHforallmodesoftransport
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