Basic Description

Synonyms	BC-1215 \| 1507370-20-8 \| N1,N2-Bis(4-(pyridin-2-yl)benzyl)ethane-1,2-diamine \| N,N'-Bis[(4-pyridin-2-ylphenyl)methyl]ethane-1,2-diamine \| N1,N2-Bis[[4-(2-pyridinyl)phenyl]methyl]- 1,2-ethanediamine \| {[4-(PYRIDIN-2-YL)PHENYL]METHYL}[2-({[4-(PYRIDIN-2-YL)PHENYL]METH
Specifications & Purity	10mM in DMSO
Biochemical and Physiological Mechanisms	BC-1215 is an inhibitor of F-box protein 3 (Fbxo3, a ubiquitin E3 ligase component) with IC50 of 0.9 μg/mL and LC50 of 87 μg/ml for IL-1β release. BC-1215 inhibits the Fbxo3-TRAF activation pathway by destabilizing TRAF1-6.
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads
Product Description	Information BC-1215 is an inhibitor of F-box protein 3 (Fbxo3, a ubiquitin E3 ligase component) with IC50 of 0.9 μg/mL and LC50 of 87 μg/ml for IL-1β release. BC-1215 inhibits the Fbxo3-TRAF activation pathway by destabilizing TRAF1-6. Targets IL-1β release (Cell-free assay); IL-1β release (Cell-free assay) 0.9 μg/mL; 87 μg/mL(LC50)

Associated Targets(Human)

U-937 (7138 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PBMC (10003 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mus musculus (284745 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

IUPAC Name	N,N'-bis[(4-pyridin-2-ylphenyl)methyl]ethane-1,2-diamine
INCHI	InChI=1S/C26H26N4/c1-3-15-29-25(5-1)23-11-7-21(8-12-23)19-27-17-18-28-20-22-9-13-24(14-10-22)26-6-2-4-16-30-26/h1-16,27-28H,17-20H2
InChi Key	IXEPQJQQSLMESJ-UHFFFAOYSA-N
Canonical SMILES	C1=CC=NC(=C1)C2=CC=C(C=C2)CNCCNCC3=CC=C(C=C3)C4=CC=CC=N4
Isomeric SMILES	C1=CC=NC(=C1)C2=CC=C(C=C2)CNCCNCC3=CC=C(C=C3)C4=CC=CC=N4
WGK Germany	3
PubChem CID	72201045
Molecular Weight	394.51

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Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H302:Harmful if swallowed
Precautionary Statements	P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help.
WGK Germany	3
RIDADR	NONHforallmodesoftransport

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