Basic Description

Synonyms	20448-79-7 \| 2-Aminobicyclo[2.2.1]heptane-2-carboxylic acid \| 2-Amino-2-norbornanecarboxylic acid \| 2-Aminonorbornane-2-carboxylic acid \| BCH \| LAT1-IN-1 \| CHEMBL2074957 \| Bicyclo[2.2.1]heptane-2-carboxylic acid, 2-amino- \| b-BCH \| Bicyclo(2.2.1)heptane-2-carboxylic acid,
Specifications & Purity	Moligand™, 10mM in Water
Biochemical and Physiological Mechanisms	Inhibitor ofL-type amino acid transporter LAT1. Suppresses growth and induces apoptosis via activation of caspases in KB, Saos2 and C6 cancer cell lines.
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™

Associated Targets(Human)

MCF7 (126967 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLC7A5 Tchem L-type amino acid transporter 1 (388 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLC43A1 Tbio L-type amino acid transporter 3 (7 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Slc16a10 Monocarboxylate transporter 10 (73 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

IUPAC Name	2-aminobicyclo[2.2.1]heptane-2-carboxylic acid
INCHI	InChI=1S/C8H13NO2/c9-8(7(10)11)4-5-1-2-6(8)3-5/h5-6H,1-4,9H2,(H,10,11)
InChi Key	MPUVBVXDFRDIPT-UHFFFAOYSA-N
Canonical SMILES	C1CC2CC1CC2(C(=O)O)N
Isomeric SMILES	C1CC2CC1CC2(C(=O)O)N
PubChem CID	115288
Molecular Weight	155.2

Enter Lot Number to search for COA:

1. Longfa Kou, Xinyu Jiang, Yingying Tang, Xing Xia, Yingtao Li, Aimin Cai, Hailun Zheng, Hailin Zhang, Vadivel Ganapathy, Qing Yao, Ruijie Chen. (2022) Resetting amino acid metabolism of cancer cells by ATB0,+-targeted nanoparticles for enhanced anticancer therapy. Bioactive Materials, 9 (15). [PMID:34820552] [10.1016/j.bioactmat.2021.07.009]
2. Xueqian Yin, Pengfei Tan, Hao Luo, Jianwu Lan, Yidong Shi, Yong Zhang, Haojun Fan, Lin Tan. (2020) Study on the release behaviors of berberine hydrochloride based on sandwich nanostructure and shape memory effect. Materials Science & Engineering C-Materials for Biological Applications, 109 (110541). [PMID:32228975] [10.1016/j.msec.2019.110541]

1. Longfa Kou, Xinyu Jiang, Yingying Tang, Xing Xia, Yingtao Li, Aimin Cai, Hailun Zheng, Hailin Zhang, Vadivel Ganapathy, Qing Yao, Ruijie Chen. (2022) Resetting amino acid metabolism of cancer cells by ATB0,+-targeted nanoparticles for enhanced anticancer therapy. Bioactive Materials, 9 (15). [PMID:34820552] [10.1016/j.bioactmat.2021.07.009]
2. Xueqian Yin, Pengfei Tan, Hao Luo, Jianwu Lan, Yidong Shi, Yong Zhang, Haojun Fan, Lin Tan. (2020) Study on the release behaviors of berberine hydrochloride based on sandwich nanostructure and shape memory effect. Materials Science & Engineering C-Materials for Biological Applications, 109 (110541). [PMID:32228975] [10.1016/j.msec.2019.110541]

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