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BCTC - 98%, high purity , CAS No.393514-24-4, Channel blocker of TRPM8;Channel blocker of TRPV1

Moligand™
≥98%

CAS#: 393514-24-4
Formula: C₂₀H₂₅ClN₄O
Molecular Weight: 372.892
MDL number: MFCD08690556
PubChem CID: 9929425

Item Number

B133833

Grouped product items
SKU	Size	Availability	Price	Qty
B133833-10mg	10mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$84.90
B133833-50mg	50mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$312.90

Potent inhibitor of TRPV1

View related series

TRPM8 Channel blocker TRPV1 Channel blocker

Basic Description

Synonyms	BCTC\|393514-24-4\|N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)piperazine-1-carboxamide\|4-(3-Chloro-2-pyridinyl)-N-[4-(1,1-dimethylethyl)phenyl]-1-piperazinecarboxamide\|C20H25ClN4O\|N-(4-(tert-Butyl)phenyl)-4-(3-chloropyridin-2-yl)piperazine-1-carboxamide
Specifications & Purity	98%
Storage Temp	Store at -20°C
Shipped In	Dry ice
Grade	Moligand™
Action Type	CHANNEL BLOCKER
Mechanism of action	Channel blocker of TRPM8;Channel blocker of TRPV1
Product Description	BCTC is a potent and specific inhibitor of transient receptor potential cation channel subfamily M member 8 (TRPM8) in prostate cancer (PCa) DU145 cells. An effective and potent TRPV1 channel antagonist

Associated Targets

TRPV1 Tclin Transient receptor potential cation channel subfamily V member 1 23 Activities

Discover Target: TRPV1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TRPA1 Tclin Transient receptor potential cation channel subfamily A member 1 1 Activities

Discover Target: TRPA1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TRPM8 Tclin Transient receptor potential cation channel subfamily M member 8 3 Activities

Discover Target: TRPM8

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 1 Activities

Discover Target: KCNH2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)piperazine-1-carboxamide
INCHI	InChI=1S/C20H25ClN4O/c1-20(2,3)15-6-8-16(9-7-15)23-19(26)25-13-11-24(12-14-25)18-17(21)5-4-10-22-18/h4-10H,11-14H2,1-3H3,(H,23,26)
InChi Key	ROGUAPYLUCHQGK-UHFFFAOYSA-N
Canonical SMILES	CC(C)(C)C1=CC=C(C=C1)NC(=O)N2CCN(CC2)C3=C(C=CC=N3)Cl
Isomeric SMILES	CC(C)(C)C1=CC=C(C=C1)NC(=O)N2CCN(CC2)C3=C(C=CC=N3)Cl
WGK Germany	3
PubChem CID	9929425
Molecular Weight	372.892

PubChem CID

ChEMBL Ligand

BindingDB Ligand

CAS Registry No.

Certificates

Certificate of Analysis(COA)

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1 results found

Lot Number	Certificate Type	Date	Item
G1922299	Certificate of Analysis	Feb 09, 2023	B133833

Solubility

Soluble in DMSO (20 mg/ml), ethanol (15 mg/ml with warming), and DMF.

Melt Point(°C)

150-152°C

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H302:Harmful if swallowed
Precautionary Statements	P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help.
WGK Germany	3

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