BTBC is an effective and potent transient receptor potential VR1 (vanilloid-1, TRPV1) channel antagonist. VR1 (TRPV1) is a Capsaicin receptor that behaves as a non-selective cation channel that is mainly found in the sensory neurons, and specifically dete
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Action Type
CHANNEL BLOCKER
Mechanism of action
Channel blocker of TRPM8;Channel blocker of TRPV1
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
BCTC is a potent and specific inhibitor of transient receptor potential cation channel subfamily M member 8 (TRPM8) in prostate cancer (PCa) DU145 cells. An effective and potent TRPV1 channel antagonist
Associated Targets(Human)
TRPV1TclinTransient receptor potential cation channel subfamily V member 1 (23 Activities)
1.Mao LP et al.. (2021) Cold-inducible RNA-binding protein migrates from the nucleus to the cytoplasm under cold stress in normal human bronchial epithelial cells via TRPM8-mediated mechanism.. Ann Transl Med, 9 (18):(1470). [PMID:34734022]
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