σ1receptor antagonist, approximately 50-fold selective overσ2sites and ≥100-fold selective over opioid, PCP, muscarinic, dopamine,α1,α2,βadrenoceptor, 5-HT1and 5-HT2receptors. Prevents hyperlocomotion following cocaine administration in mice.BD 1063 is a
Storage Temp
Store at -20°C,Argon charged
Shipped In
Ice chest + Ice pads
Product Description
Application：
BD 1063 dihydrochloride has been used as a sigma-1 receptor (S1R) antagonist:
to study the in vitro and in vivo protective action of S1R against ferroptosis in hepatocellular carcinoma cells in a comparative evaluation of its anti-hyperalgesic action with that of the effects of N-(2-morpholin-4-yl-ethyl)-2-(1-naphthyloxy) acetamide (NMIN) in a chronic constriction injury model (CCI) to study the contribution of sigma receptors inhibition to the neuroprotective effects of memantine against amyloid-beta (Aβ)-induced neurotoxicity in SH-SY5Y cells
I2217172