BD 1063 Dihydrochloride - 10mM in DMSO, high purity , CAS No.206996-13-6(DMSO)

Item Number

B580305

• Synonyms: BD 1063 Dihydrochloride | 206996-13-6 | 150208-28-9 | BD1063 dhydrochloride | 1-[2-(3,4-Dichlorophenyl)ethyl]-4-methylpiperazine Dihydrochloride | BD1063 (dhydrochloride) | BD1063 2HCl | BD1063 | 1-(3,4-dichlorophenethyl)-4-methylpiperazine dihydrochloride | 1-[2-(3,4-dich
• Specifications & Purity: 10mM in DMSO
• Biochemical and Physiological Mechanisms: σ1receptor antagonist, approximately 50-fold selective overσ2sites and ≥100-fold selective over opioid, PCP, muscarinic, dopamine,α1,α2,βadrenoceptor, 5-HT1and 5-HT2receptors. Prevents hyperlocomotion following cocaine administration in mice.BD 1063 is a
• Storage Temp: Store at -80°C
• Shipped In: Ice chest + Ice pads

Product Description

Application：

BD 1063 dihydrochloride has been used as a sigma-1 receptor (S1R) antagonist:

to study the in vitro and in vivo protective action of S1R against ferroptosis in hepatocellular carcinoma cells in a comparative evaluation of its anti-hyperalgesic action with that of the effects of N-(2-morpholin-4-yl-ethyl)-2-(1-naphthyloxy) acetamide (NMIN) in a chronic constriction injury model (CCI) to study the contribution of sigma receptors inhibition to the neuroprotective effects of memantine against amyloid-beta (Aβ)-induced neurotoxicity in SH-SY5Y cells