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BD 1063 Dihydrochloride - 10mM in DMSO, high purity , CAS No.206996-13-6(DMSO)
Selective σ1ligand, putative antagonist
Basic Description Synonyms BD 1063 Dihydrochloride|206996-13-6|150208-28-9|BD1063 dhydrochloride|1-[2-(3,4-Dichlorophenyl)ethyl]-4-methylpiperazine Dihydrochloride|BD1063 (dhydrochloride)|BD1063 2HCl|BD1063|1-(3,4-dichlorophenethyl)-4-methylpiperazine dihydrochloride|1-[2-(3,4-dich Specifications & Purity 10mM in DMSO Storage Temp Store at -80°C Shipped In Ice chest + Ice pads Product Description Application：
BD 1063 dihydrochloride has been used as a sigma-1 receptor (S1R) antagonist:
to study the in vitro and in vivo protective action of S1R against ferroptosis in hepatocellular carcinoma cells in a comparative evaluation of its anti-hyperalgesic action with that of the effects of N-(2-morpholin-4-yl-ethyl)-2-(1-naphthyloxy) acetamide (NMIN) in a chronic constriction injury model (CCI) to study the contribution of sigma receptors inhibition to the neuroprotective effects of memantine against amyloid-beta (Aβ)-induced neurotoxicity in SH-SY5Y cells
Names and Identifiers IUPAC Name 1-[2-(3,4-dichlorophenyl)ethyl]-4-methylpiperazine;dihydrochloride INCHI InChI=1S/C13H18Cl2N2.2ClH/c1-16-6-8-17(9-7-16)5-4-11-2-3-12(14)13(15)10-11;;/h2-3,10H,4-9H2,1H3;2*1H InChi Key NXFDBTLQOARIMH-UHFFFAOYSA-N Canonical SMILES CN1CCN(CC1)CCC2=CC(=C(C=C2)Cl)Cl.Cl.Cl Isomeric SMILES CN1CCN(CC1)CCC2=CC(=C(C=C2)Cl)Cl.Cl.Cl WGK Germany 3 PubChem CID 11617161 Molecular Weight 346.12
Chemical and Physical Properties Solubility Solvent:water, Max Conc. mg/mL: 34.61, Max Conc. mM: 100；H2O: >15 mg/mL Sensitivity Moisture sensitive Melt Point(°C) >220°C (dec.)
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H319: Causes serious eye irritation
Precautionary Statements P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P264: Wash hands [and …] thoroughly after handling.
P337+P313: IF eye irritation persists: Get medical advice/attention.
WGK Germany 3
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