2-[(3S)-3-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]acetic acid hydrochloride | 5NSA | Benazepril hydrochloride, European Pharmacopoeia (EP) Reference Standard | SR-01000762893-3 | HY-B0093A | NCGC000951
Specifications & Purity
≥99%
Biochemical and Physiological Mechanisms
Benazepril hydrochloride is an ACE (angiotensin-converting enzyme) inhibitor. This prevents the catalytic conversion of angiotensin I to angiotensin II and in turn causes vasodilation and an increase in capillary blood volume.Angiotensin-converting enzyme
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Action Type
INHIBITOR
Mechanism of action
Angiotensin-converting enzyme inhibitor
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
1.Wang Yiran, Shi Jihua, Dai Dapeng, Cai Jianping, Wang Shuanghu, Hong Yun, Zhou Shan, Zhao Fangling, Zhou Quan, Geng Peiwu, Zhou Yunfang, Xu Xue, Luo Qingfeng. (2022) Evaluation of commonly used cardiovascular drugs in inhibiting vonoprazan metabolism in vitro and in vivo. Frontiers in Pharmacology, 13 [PMID:36052128][10.3389/fphar.2022.909168]
2.Tan Lihua, Tu Yanbei, Wang Kai, Han Bing, Peng Hongquan, He Chengwei. (2020) Exploring protective effect of Glycine tabacina aqueous extract against nephrotic syndrome by network pharmacology and experimental verification. Chinese Medicine, 15 (1):(1-17). [PMID:32765640][10.1186/s13020-020-00361-7]
3.Zheng Di-Wei, Pan Pei, Chen Ke-Wei, Fan Jin-Xuan, Li Chu-Xin, Cheng Han, Zhang Xian-Zheng. (2020) An orally delivered microbial cocktail for the removal of nitrogenous metabolic waste in animal models of kidney failure. Nature Biomedical Engineering, 4 (9):(853-862). [PMID:32632226][10.1038/s41551-020-0582-1]
References
1.Wang Yiran, Shi Jihua, Dai Dapeng, Cai Jianping, Wang Shuanghu, Hong Yun, Zhou Shan, Zhao Fangling, Zhou Quan, Geng Peiwu, Zhou Yunfang, Xu Xue, Luo Qingfeng. (2022) Evaluation of commonly used cardiovascular drugs in inhibiting vonoprazan metabolism in vitro and in vivo. Frontiers in Pharmacology, 13 [PMID:36052128][10.3389/fphar.2022.909168]
2.Tan Lihua, Tu Yanbei, Wang Kai, Han Bing, Peng Hongquan, He Chengwei. (2020) Exploring protective effect of Glycine tabacina aqueous extract against nephrotic syndrome by network pharmacology and experimental verification. Chinese Medicine, 15 (1):(1-17). [PMID:32765640][10.1186/s13020-020-00361-7]
3.Zheng Di-Wei, Pan Pei, Chen Ke-Wei, Fan Jin-Xuan, Li Chu-Xin, Cheng Han, Zhang Xian-Zheng. (2020) An orally delivered microbial cocktail for the removal of nitrogenous metabolic waste in animal models of kidney failure. Nature Biomedical Engineering, 4 (9):(853-862). [PMID:32632226][10.1038/s41551-020-0582-1]
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I2207440